个人简介

Fellow of the Royal Academy of Engineering Fellow of the Institution of Chemical Engineering Council Member of the Institution of Chemical Engineering (1995-1997) Editorial Board for Bioprocess and Biosystems Engineering Editorial Board for Biotechnology and Bioengineering Subject Editor for Trans. IChemE (Part C) Member, Engineering Council Nominations and Audit Committee (1996 - 2002) Member, American Institute of Chemical Engineers Member, EPSRC Peer Review College Conference Chair, Recovery of Biological Products XI & XIV Board Member of Recovery of Biological Products – Conference Series Member, Organizing Committee 2000 World Congress of Chemical Engineering Member, IChemE Membership Committee Member, BioProcess UK Advisory Board Member, BRIC Steering Group Member, IBC Scientific Advisory BoardEsso Centenary Fellowship (1990-1994) Esso Centenary Fellowship (1990-1994)

研究领域

Nigel Titchener-Hooker leads the EPSRC Centre for Innovative Manufacture in Emergent Macromolecular Therapies and was the past lead of the UCL Innovative Manufacturing Research Centre (IMRC) in Bioprocessing programme. This involves a multidisciplinary group from over a dozen departments to research new methods to speed the development of efficient and robust processes for the manufacture of the next generations of macromolecular drugs. The work brings together researchers from Structural and Molecular Biology (Professor John Ward), and within the Faculty of Engineering Science significant collaborations exist with Computer Science (Professor Tony Hunter), Chemical Engineering (Dr. Eva Sorenson and Dr. Lazaros Papageorgiou). Internally Dr. Dan Bracewell, Dr. Nicolas Szita, Dr. Yuhong Zhou, Dr. Eli Keshavarz-Moore and Professor Mike Hoare help Nigel in the management of the IMRC consortium that comprises 15 leading national and international companies. A major focus of Nigel’s work is the creation of whole bioprocess models and the use of these to gain process insights and understanding. Here he works with Dr. Yuhong Zhou in the creation of graphical user interfaces to visualise better process trade offs. With Dr. Suzanne Farid, Nigel has pioneered studies of decisional tools addressing the interface between bioprocessing and business issues. In line with the theme of whole bioprocess modelling, Nigel has collaborated with colleagues at Newcastle University (Professor Gary Montague, Professor Elaine Martin and Dr. Jarka Glassey) to create new ways of improving the performance of manufacturing processes by combining IMRC tools with agent-based methods. Nigel chairs the Engineering Doctorate (EngD) in Bioprocess Leadership activity now directed by Prof Gary Lye. Since its inception the EngD programme has attracted over 60 sponsor companies to date and nearly 100 projects have been funded under this mechanism which complements the research within the Department. Funding for the above research has come from the UK EPSRC, the TSB Technology Programme and a range of company collaborators. Nigel has held consultancies with a broad range of international companies and serves on the editorial board of key peer-reviewed journals. He was elected a Fellow of the Royal Academy of Engineering in 2008 in recognition of his pioneering work on biopharmaceuticals manufacturing. He is a Fellow of the Institution of Chemical Engineers and was awarded the Donal Medal for hsi contributions to Biochemical Engineering in 2013. He is Chair of the Board of the prestigious ACS-supported Recovery of Biological Products conference series.

Bioprocessing Global Health Synthetic Biology

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

A scale-down mimic for mapping the process performance of centrifugation, depth and sterile filtration Journal article; 2016; Biotechnology and Bioengineering Links: IRIS | UCL Discovery | DOI Authors: Joseph A,Kenty B,Mollet M,Hwang K,Rose S,Goldrick S,Bender J,Farid SS,Titchener-Hooker N click to collapse Integrated economic and experimental framework for screening of primary recovery technologies for high cell density CHO cultures Journal article; 2016; Biotechnology Journal Links: IRIS | UCL Discovery | DOI | Publisher Authors: Popova D,Stonier A,Pain D,Titchener-Hooker NJ,Farid SS click to collapse Integration of bioreactors with downstream steps Chapter; 2016; Links: IRIS Authors: Velayudhan AK,Titchener-Hooker NJ click to collapse Life-Cycle and Cost of Goods Assessment of Fed-batch and Perfusion-based Manufacturing Processes for mAbs. Journal article; 2016; Biotechnology progress Links: IRIS Authors: Bunnak P,Allmendinger R,Ramasamy SV,Lettieri P,Titchener-Hooker NJ click to collapse Economic Analysis of Royalactin Production Under Uncertainty: Evaluating the Effect of Parameter Optimization Journal article; 2015; BIOTECHNOLOGY PROGRESS Links: IRIS | UCL Discovery | Author's | DOI Authors: Torres-Acosta MA,Aguilar-Yanez JM,Rito-Palomares M,Titchener-Hooker NJ click to collapse Economic analysis of uricase production under uncertainty: Contrast of chromatographic purification and aqueous two-phase extraction (with and without PEG recycle) Journal article; 2015; BIOTECHNOLOGY PROGRESS Links: IRIS | UCL Discovery | Author's | DOI Authors: Torres-Acosta MA,Aguilar-Yanez JM,Rito-Palomares M,Titchener-Hooker NJ click to collapse Editorial overview: Biotechnology and Bioprocess Engineering: celebrating the 65th anniversary of 'Oxygen Transfer in Submerged Fermentations', marking the birth of modern Biochemical Engineering Journal article; 2015; CURRENT OPINION IN CHEMICAL ENGINEERING Links: IRIS | Author's | DOI Authors: Papoutsakis ET,Titchener-Hooker NJ click to collapse Life cycle assessment as a tool to support decision making in the biopharmaceutical industry: Considerations and challenges Journal article; 2015; FOOD AND BIOPRODUCTS PROCESSING Links: IRIS | Author's | DOI Authors: Ramasamy V,Titchener-Hooker NJ,Lettieri P click to collapse Optimal Resin Selection for Integrated Chromatographic Separations in High-Throughput Screening Conference ; 2015; 12TH INTERNATIONAL SYMPOSIUM ON PROCESS SYSTEMS ENGINEERING AND 25TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, PT C Links: IRIS | Author's Authors: Liu S,Gerontas S,Gruber D,Turner R,Titchener-Hooker NJ,Papageorgiou LG click to collapse Representative mammalian cell culture test materials for assessment of primary recovery technologies: a rapid method with industrial applicability. Journal article; 2015; Biotechnol J Links: IRIS | UCL Discovery | Author's | DOI Authors: Popova D,Stonier A,Pain D,Titchener-Hooker NJ,Farid SS click to collapse Editorial overview: Biotechnology and bioprocess engineering Journal article; 2014; CURRENT OPINION IN CHEMICAL ENGINEERING Links: IRIS | Author's | DOI Authors: Papoutsakis ET,Titchener-Hooker NJ click to collapse Integration of host strain bioengineering and bioprocess development using ultra-scale down studies to select the optimum combination: an antibody fragment primary recovery case study. Journal article; 2014; Biotechnol Bioeng Links: IRIS | UCL Discovery | Author's | DOI Authors: Aucamp JP,Davies R,Hallet D,Weiss A,Titchener-Hooker NJ click to collapse Quantitative High Throughput Analytics to Support Polysaccharide Production Process Development Journal article; 2014; Vaccine Links: IRIS | UCL Discovery | DOI Authors: Noyes A,Godavarti R,Titchener-Hooker N,Coffman J,Mukhopadhyay TK click to collapse Tuning Evolutionary Multiobjective Optimization for Closed-Loop Estimation of Chromatographic Operating Conditions Journal article; 2014; Lecture Notes in Computer Science Links: IRIS | UCL Discovery | DOI Authors: Allmendinger ,Farid SS click to collapse Challenges of developing decision-support LCA tools in the biopharmaceutical industry Conference ; Links: IRIS | UCL Discovery Authors: Ramasamy S,Titchener-Hooker N,Lettieri P click to collapse Evaluation of a structural mechanics model to predict the effect of inserts in the bed support of chromatographic columns Journal article; 2013; ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Links: IRIS | UCL Discovery | Author's Authors: Gerontas S,Lan T,Titchener-Hooker NJ click to collapse Evaluation of a structural mechanics model to predict the effect of inserts in the bed support of chromatographic columns Conference ; 2013; ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Links: IRIS | UCL Discovery | Author's Authors: Gerontas S,Lan T,Titchener-Hooker NJ click to collapse Measurement and control of bioprocesses.Preface. Journal article; 2013; Adv Biochem Eng Biotechnol Links: IRIS | UCL Discovery | Author's Authors: Mandenius C,Titchener-Hooker NJ click to collapse Measurement, Monitoring, Modelling and Control of Bioprocesses Preface Journal article; 2013; MEASUREMENT, MONITORING, MODELLING AND CONTROL OF BIOPROCESSES Links: IRIS | UCL Discovery | Author's Authors: Mandenius C-F,Titchener-Hooker NJ click to collapse Study of the conditions for multi-modal chromatographic capture of Fab from dual-salt precipitated E. coli homogenate Journal article; 2013; JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Balasundaram B,Chhatre S,Arora D,Titchener-Hooker NJ,Bracewell DG click to collapse Automated methods for accurate determination of the critical velocity of packed bed chromatography. Journal article; 2012; Biotechnol Prog Links: IRIS | UCL Discovery | Author's | DOI Authors: Chang YC,Gerontas S,Titchener-Hooker NJ click to collapse Investigating the use of column inserts to achieve better chromatographic bed support Journal article; 2012; BIOTECHNOLOGY PROGRESS Links: IRIS | UCL Discovery | Author's | DOI Authors: Lan T,Gerontas S,Smith GR,Langdon J,Ward JM,Titchener-Hooker NJ click to collapse Investigating the use of column inserts to achieve better chromatographic bed support. Journal article; 2012; Biotechnol Prog Links: IRIS | UCL Discovery | Author's | DOI Authors: Lan T,Gerontas S,Smith GR,Langdon J,Ward JM,Titchener-Hooker NJ click to collapse The hybrid experimental simplex algorithm ? An alternative method for ?sweet spot? identification in early bioprocess development: Case studies in ion exchange chromatography Journal article; 2012; Analytica Chimica Acta Links: IRIS | UCL Discovery | DOI Authors: Konstantinidis S,Chhatre S,Velayudhan A,Heldin E,Titchener-Hooker N click to collapse Utilisation of key descriptors from protein sequence data to aid bioprocess route selection Journal article; 2012; Food and Bioproducts Processing Links: IRIS | UCL Discovery Authors: O'Malley CJ,Montague GA,Martin EB,Liddell JM,Kara B,Titchener-Hooker NJ click to collapse