Szita, Nicolas - University College London - Department of Biochemical Engineering

个人简介

Associate Professor (Lektor), Biochemical Microreactors Group, Technical University of Denmark (DTU), Denmark (2005-2007) Postdoctoral Research Associate, Chemical Engineering, Massachusetts Institute of Technology, USA (2001-2005) Postdoctoral Research Associate, Mechanical and Process Engineering, ETH Zurich, Switzerland (2001) Research and Teaching Assistant, Mechanical and Process Engineering, ETH Zurich, Switzerland (1996-2001) Guest Editorial in Journal of Biomedical Microdevices on Novel Fabrication Methods for BioMEMS Jacques Edouard Rott Award from ETH Zurich

研究领域

Nicolas Szita’s research interests focus on the translation of bioprocessing concepts into microfluidic systems (or Lab-on-a-chip systems). He has particular expertise in the use of advanced microfabrication techniques for polymers (rapid prototyping), glass and silicon. He co-ordinates the research activities of the Microfluidics Laboratory in Biochemical Engineering, and collaborates with the London Centre for Nanotechnology (LCN). Microfluidic devices provide an environment conducive to cell growth, operate with much smaller volumes, reducing the amount of cells and media required, and can be fitted with instrumentation for the real-time monitoring of assays. Additionally, they offer advantages unavailable at the larger scales, such as precise temporal and spatial control over the cellular microenvironment, and the scale-out to platforms of multiple microfluidic systems for high-throughput applications. Microfluidic systems are thus particularly suitable for the development of novel bioprocesses and the optimisation of bioprocesses for scale-up. Current research includes Ph.D. projects on the use of microfluidic systems to process tiny amounts of precious human cells for drug discovery and cell therapy (with Dr Farlan Veraitch), the characterisation of mass transfer in microfluidic devices for mammalian cell culturing (with Prof Gary Lye), the establishment of experimental approaches for enzymatic bioconversion in microfluidic reactors (with Dr Frank Baganz and Dr H.C Hailes, Chemistry, as part of the Bioconversion-Chemistry-Engineering Interface, BiCE). Nicolas Szita is particularly active in the applications of microfluidics to Synthetic Biology. Together with Dr S. Cockroft (U of Edinburgh, Consortium Leader), Dr J. Howse (U of Sheffield), Dr L. Dougan (U of Leeds), and Dr K Polizzi (Imperial), he has won a Flashlight Funding research grant in Synthetic Biology (“Enabling Tools & Technologies in Synthetic Biology”). In the framework of an European European Science Foundation (ESF) EuroCORES Eurosynbio grant (“Synthetic Biology To Obtain Novel Antibiotics and Optimized Production Systems”, SYNMOD), he develops parallelised microfluidic bioreactors for the rapid acquisition of design-relevant gene expression parameters in the required statistical depth. The consortium members include Prof O Kuipers (University of Groningen, Consortium Leader), Prof S Panke (ETH Zurich), Prof F Götz (Eberhard Karls Universität of Tübingen), Prof R Wagner (Universität Regensburg), and Dr M Schmidt (Organisation for International Dialogue and Conflict Management in Austria).

近期论文

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Real-time pH monitoring of industrially relevant enzymatic reactions in a microfluidic side-entry reactor (?SER) shows potential for pH control Journal article; 2017; Biotechnology Journal Links: IRIS | UCL Discovery | DOI Authors: Gruber P,Marques MPC,Sulzer P,Wohlgemuth R,Mayr T,Baganz F,Szita N click to collapse Real-time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device Journal article; 2016; BIOTECHNOLOGY JOURNAL Links: IRIS | UCL Discovery | Author's | DOI Authors: Super A,Jaccard N,Marques MPC,Macown RJ,Griffin LD,Veraitch FS,Szita N click to collapse Automated method for the rapid and precise estimation of adherent cell culture characteristics from phase contrast microscopy images Journal article; 2014; Biotechnology and Bioengineering Links: IRIS | UCL Discovery | DOI Authors: Jaccard N,Griffin LD,Keser A,Macown RJ,Super A,Veraitch FS,Szita N click to collapse ECO-FRIENDLY PRODUCTION OF CHEMICALS 1. IMPROVEMENT OF ENZYMATIC PRODUCTION OF ACETOPHENONE BY DIRECT EXTRACTION Conference presentation; 2016; Links: IRIS | Author's Authors: Kloetzer L,Petrila-Cocuz I-B,Galaction A-I,Szita N,Blaga A-C,Cascaval D click to collapse Label-free quantification of proliferation and specific oxygen uptake rates from un-disrupted embryonic stem cell cultures in a microfluidic device Conference presentation; 2016; Links: IRIS | Author's Authors: Szita N,Jaccard N,Super A,Macown RJ,Marques MPC,Veraitch FS,Szita N click to collapse Quantification of the oxygen uptake rate in a dissolved oxygen controlled oscillating jet-driven microbioreactor Journal article; 2016; JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Kirk TV,Marques MPC,Radhakrishnan ANP,Szita N click to collapse Transfection in perfused microfluidic cell culture devices: a case study Journal article; 2016; Process Biochemistry Links: IRIS | UCL Discovery | DOI Authors: Raimes W,Rubi M,Super ASM,Marques M,Veraitch F,Szita N click to collapse Electromagnetic stirring in a microbioreactor with non-conventional chamber morphology and implementation of multiplexed mixing Journal article; 2015; Journal of Chemical Technology and Biotechnology Links: IRIS | UCL Discovery | DOI Authors: Tan CK,Davies MJ,Mccluskey DK,Munro IR,Nweke MC,Tracey MC,Szita N click to collapse Micropillar-based aqeous-organic continuous liquid-liqiud extraction device with very long residence times for the extraction of pharmaceutical compounds Conference ; 2015; MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences Links: IRIS Authors: Chiang YY,Dimov N,Marques MPC,Baganz F,Szita N click to collapse Micropillar-Based Aqueous-Organic Continuous Liquid-Liquid Extraction Device Conference ; Links: IRIS Authors: Chiang ,Dimov N,Marques MP,Baganz F,Szita N click to collapse Segmentation of phase contrast microscopy images based on multi-scale local Basic Image Features histograms Journal article; 2015; Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization Links: IRIS | DOI Authors: Jaccard N,Szita N,Griffin LD click to collapse Automated and online characterization of adherent cell culture growth in a microfabricated bioreactor. Journal article; 2014; J Lab Autom Links: IRIS | UCL Discovery | Author's | DOI Authors: Jaccard N,Macown RJ,Super A,Griffin LD,Veraitch FS,Szita N click to collapse Characterisation of an Adhesive-free Packaging System for Polymeric Microfluidic Biochemical Devices and Reactors Journal article; 2014; Chemical and Biochemical Engineering Quarterly Links: IRIS | UCL Discovery | DOI | Publisher Authors: Reichen M,Super AMC,Davies MJ,Macown RJ,O'Sullivan B,Kirk TV,Marques MPC,Dimov N,Szita N click to collapse Influence of Initial Seeding Density on Gene Expression during Neuronal Priming Journal article; 2014; Journal of Bioprocessing & Biotechniques Links: IRIS | UCL Discovery | DOI Authors: Thwaites JW,Ruban L,Mason C,Dalby P,Habib N,Jaccard N,Szita N,Wall I click to collapse Microfabricated cell culture device for stem cell bioprocessing with qualitative online monitoring Conference ; 2014; 4th International Conference on Stem Cell Engineering 2014 Links: IRIS Authors: Szita N Robust, microfabricated culture devices with improved control over the soluble microenvironment for the culture of embryonic stem cells. Journal article; 2014; Biotechnol J Links: IRIS | Author's | DOI Authors: Macown RJ,Veraitch FS,Szita N click to collapse Trainable Segmentation of Phase Contrast Microscopy Images Based on Local Basic Image Features Histograms. Conference ; 2014; MIUA Links: IRIS | Publisher Authors: Jaccard N,Szita N,Griffin LD click to collapse Characterization and multi-step transketolase-?-transaminase bioconversions in an immobilized enzyme microreactor (IEMR) with packed tube Journal article; 2013; Journal of Biotechnology Links: IRIS | UCL Discovery | DOI Authors: Abdul Halim A,Szita N,Baganz F click to collapse Characterization and multi-step transketolase-?-transaminase bioconversions in an immobilized enzyme microreactor (IEMR) with packed tube. Journal article; 2013; J Biotechnol Links: IRIS | UCL Discovery | Author's | DOI Authors: Halim AA,Szita N,Baganz F click to collapse Development of a microbioreactor 'cassette' for the cultivation of microorganisms in batch and chemostat mode Journal article; 2013; CHIMICA OGGI-CHEMISTRY TODAY Links: IRIS | UCL Discovery | Author's Authors: Davies MJ,Nesbeth DN,Szita N click to collapse Development of a microbioreactor 'cassette' for the cultivation of microorganisms in batch and chemostat mode. Journal article; 2013; Chimica Oggi Links: IRIS | UCL Discovery | Author's | Publisher Authors: davies M,Nesbeth DN,szita N click to collapse Development of a microfluidic platform for the on-line study of flocculation growth kinetics Journal article; 2013; 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 Links: IRIS | UCL Discovery Authors: Pallipurath Radhakrishnan AN,O'Sullivan B,Bracewell DG,Szita N click to collapse Development of a multiplexed microfluidic platform for the automated cultivation of embryonic stem cells. Journal article; 2013; J Lab Autom Links: IRIS | UCL Discovery | Author's | DOI Authors: Reichen M,Veraitch FS,Szita N click to collapse Microfluidic multi-input reactor for biocatalytic synthesis using transketolase Journal article; 2013; Journal of Molecular Catalysis B: Enzymatic Links: IRIS | UCL Discovery | Author's | DOI Authors: Lawrence J,O'Sullivan B,Lye GJ,Wohlgemuth R,Szita N click to collapse Oxygen transfer characteristics of miniaturized bioreactor systems. Journal article; 2013; Biotechnol Bioeng Links: IRIS | UCL Discovery | Author's | DOI Authors: Kirk TV,Szita N click to collapse