Mukhopadhyay, Tarit - University College London - Department of Biochemical Engineering

个人简介

Chair of the Vaccine Development Working Group for the UK Vaccine Network (2016-present) mukhopadhyay-2 Treasurer, Process Engineering Group, Society of Chemical Industry, (2003-2005) Messel Bursary Award (2004) Associate Member of the Institute of Chemical Engineers, (2002) Sir Derek Roberts Scholarship in Biochemical Engineering, (1999)

研究领域

Tarit's previous experience is in protein and bacterial vaccines (Meningitis B and the UK licensed Anthrax vaccine) with the Health Protection Agency, Porton Down. He now primarily works on virus and virus-like particle processes. This includes cell expression and induction, Up Stream Processing, Inactivation, Down Stream Processing studies looking at filtration, formulation and chromatography. A new focus has been conjugate vaccines. The primary methodology is to create scale-down models that mimic the processing environment to determine CQA/CPP that can be accurately applied to the commercial scale. The obvious benefits being speed, (reducing time to market) and cost. Other interests are hydrodynamic and physiological effects on antigen recovery on potency, such as shear and aggregation effects. Current Collaborators Intercell Biomedical, Oxford Biomedica, Pfizer, London Centre for Nanotechnology, GSK, iQur

近期论文

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A modular approach for the ultra-scale-down of depth filtration Journal article; 2015; JOURNAL OF MEMBRANE SCIENCE Links: IRIS | Author's | DOI Authors: Noyes A,Basha J,Frostad J,Cook S,Millard D,Mullin J,LaCasse D,Wright RS,Huffman B,Fahrner R,Godavarti R,Titchener-Hookert N,Sunasara K,Mukhopadhyay T click to collapse High throughput screening of particle conditioning operations: I. System design and method development Journal article; 2015; BIOTECHNOLOGY AND BIOENGINEERING Links: IRIS | UCL Discovery | Author's | DOI Authors: Noyes A,Huffman B,Godavarti R,Titchener-Hooker N,Coffman J,Sunasara K,Mukhopadhyay T click to collapse High throughput screening of particle conditioning operations: II. Evaluation of scale-up heuristics with prokaryotically expressed polysaccharide vaccines Journal article; 2015; BIOTECHNOLOGY AND BIOENGINEERING Links: IRIS | UCL Discovery | Author's | DOI Authors: Noyes A,Huffman B,Berrill A,Merchant N,Godavarti R,Titchener-Hooker N,Coffman J,Sunasara K,Mukhopadhyay T click to collapse Opportunities and Limitations of Vaccine Process Analytics Conference presentation; 2015; Links: IRIS | UCL Discovery | Publisher Authors: Mukhopadhyay TK No change for Big Pharma? Journal article; 2014; CHEMISTRY & INDUSTRY Links: IRIS | UCL Discovery | Author's | DOI Authors: Mukhopadhyay T Quantitative High Throughput Analytics to Support Polysaccharide Production Process Development Journal article; 2014; Vaccine Links: IRIS | UCL Discovery | DOI Authors: Noyes A,Godavarti R,Titchener-Hooker N,Coffman J,Mukhopadhyay TK click to collapse Scale-up and process development of VLPs (virus like particles) Conference presentation; 2014; Links: IRIS | UCL Discovery Authors: Mukhopadhyay TK Characterization of lentiviral vector production using microwell suspension cultures of HEK293T-derived producer cells. Journal article; 2013; Hum Gene Ther Methods Links: IRIS | UCL Discovery | Author's | DOI Authors: Guy HM,McCloskey L,Lye GJ,Mitrophanous KA,Mukhopadhyay TK click to collapse High throughput quantification of capsular polysaccharides for multivalent vaccines using precipitation with a cationic surfactant Journal article; 2013; Vaccine Links: IRIS | UCL Discovery | DOI Authors: Noyes A,Boesch A,Godavarti R,Titchener-Hooker N,Coffman J,Mukhopadhyay T click to collapse High throughput, turbidimetric assay for the quantification of capsular polysaccharides Conference ; 2013; ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Links: IRIS | UCL Discovery | Author's Authors: Noyes A,Boesch A,Godavarti R,Titchener-Hooker N,Coffman J,Mukhopadhyay T click to collapse Microscale models and their application to vaccine development Conference presentation; 2012; Links: IRIS | UCL Discovery | Publisher Authors: Mukhopadhyay TK Microscale vaccine development ? a tool set for success? Conference presentation; 2012; Links: IRIS | UCL Discovery | Publisher Authors: Mukhopadhyay TK Use of microwells to investigate the effect of quorum sensing on growth and antigen production in Bacillus anthracis Sterne 34F2. Journal article; 2011; J Appl Microbiol Links: IRIS | UCL Discovery | Author's | DOI Authors: Mukhopadhyay TK,Allison N,Charlton S,Ward J,Lye GJ click to collapse Evaluation of anthrax vaccine production by Bacillus anthracis Sterne 34F(2) in stirred suspension culture using a miniature bioreactor: A useful scale-down tool for studies on fermentations at high containment Journal article; 2010; BIOCHEMICAL ENGINEERING JOURNAL Links: IRIS | UCL Discovery | Author's | DOI Authors: Mukhopadhyay TK,Allison N,Charlton S,Hudson MJ,Hallis B,King A,Baker R,Noonan S,McGlashan J,West K,Levy MS,Ward JM,Lye GJ click to collapse Vaccines Europe 2009. Journal article; 2010; Expert Rev Vaccines Links: IRIS | UCL Discovery | Author's | DOI Authors: Mukhopadhyay TK Anthrax Vaccine Development using a miniature bioreactor as a scale-down tool Conference presentation; Links: IRIS | UCL Discovery | Publisher Authors: Mukhopadhyay TK Microscale models and their application to vaccine development Conference presentation; 2009; Links: IRIS | UCL Discovery | Publisher Authors: Mukhopadhyay TK Microscale Vaccine Development of the UK Licensed Anthrax Vaccine Conference presentation; 2009; Links: IRIS | UCL Discovery Authors: Mukhopadhyay TK Rapid Vaccine Development and Characterisation using SELDI Mass spectrometry Conference presentation; 2009; Links: IRIS | UCL Discovery Authors: Mukhopadhyay TK Selective recovery methodology for the primary purification of lipid enveloped virus like particles from S. cerevisiae Conference presentation; 2009; Links: IRIS | UCL Discovery Authors: Mukhopadhyay TK Micro scale experiments coupled with statistical design ? a smart tool for vaccine development Conference presentation; Links: IRIS | UCL Discovery Authors: Mukhopadhyay TK The Emergence of LEDC manufacturers ? economics of vaccine development Conference presentation; 2008; Links: IRIS | UCL Discovery Authors: Mukhopadhyay TK Chemistry must inspire Journal article; 2006; Chemistry and Industry (London) Links: IRIS Authors: Mukhopadhyay TK Stop clinical trials in developing nations Journal article; 2006; CHEMISTRY & INDUSTRY Links: IRIS | UCL Discovery | Author's Authors: Mukhopadhyay TK Rapid characterization of outer-membrane proteins in Neisseria lactamica by SELDI-TOF-MS (surface-enhanced laser desorption ionization-time-of-flight MS) for use in a meningococcal vaccine Journal article; 2005; BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY Links: IRIS | UCL Discovery | Author's Authors: Mukhopadhyay TK,Halliwell D,O'Dwyer C,Shamlou PA,Levy MS,Allison N,Gorringe A,Reddin KM click to collapse