Micheletti, Martina - University College London - Department of Biochemical Engineering

个人简介

Research Associate, King’s College London (2004) Post-Doctoral Research Associate, University College London (2004-2007) Associate Member of the Institution of Chemical Engineers

研究领域

Martina Micheletti is a Lecturer in Biochemical Engineering at University College London. Dr Micheletti's research focuses on the study of the influence of the engineering environment on different types of biological organisms in upstream and downstream bioprocessing operations with the aim to address key challenges in the scale-up of pharmaceutical processes. She graduated in Chemical Engineering from the University of Pisa and got her PhD in Mechanical Engineering from King's College London in 2004 for her work on fluid dynamics in reactors under the guidance of Professor Yianneskis. She then obtained a postdoctoral research associate position as part of the Bioconversion Chemistry-Engineering Interface (BiCE) programme led by Gary Lye and became a Lecturer in Biochemical Engineering in 2007. She is responsible for the research on engineering fundamentals underpinning bioprocess operations and high throughput development in biocatalysis and biopharmaceutical processes. Dr Micheletti’s research interests lie in the fundamental fluid mechanics that underpin the design and scale-up of a variety of bioprocess unit operations. She has particular expertise in the use of advanced optical techniques for the measurement and quantification of fluid flows. In particular she has used techniques such as Laser Doppler Anemometry and Particle Image Velocimetry to study velocity characteristics in multi-phase flows in stirred vessels. Within the Bioconversion Chemistry-Engineering Interface (BiCE) programme, she has been responsible for establishing microscale bioprocessing techniques in order to speed up bioprocess development. She demonstrated the creation of a whole process sequence, on the deck of an automated platform, for the rapid evaluation of large libraries of evolved biocatalysts and successfully compared microscale data to those obtained in conventional lab scale bioreactors. Working in collaboration with the other BiCE researchers, she has also been involved in demonstrating the use of microscale-collected data for the evaluation of bioconversion kinetic parameters using modelling approaches. Current research focuses on the miniaturization of fermentation and bioconversion operations using oxidative enzymes and on the measurement of fundamental engineering variables that underpin subsequent bioprocesses scale-up. These aspects have been extended to also cover the scale-down of downstream processing operations such as cross-flow filtration and inclusion-body derived protein refolding as part of the IMRC in Bioprocessing. Dr Micheletti has been involved in the development of a new Responsive Bioprocessing Facility located in the department's Advanced Centre for Biochemical Engineering. The Facility is equipped with the latest single-use technology at laboratory and pilot scale for the study of flexible biopharmaceutical manufacturing. Martina's leads research studies focusing on the fundamental engineering characterisation of such technology for improved scale-up.

近期论文

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Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels Journal article; 2016; JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC Links: IRIS | Author's | DOI Authors: Markosova K,Dolejs I,Stloukal R,Rios-Solis L,Rosenberg M,Micheletti M,Lye GJ,Turner NJ,Rebros M click to collapse Appraisal of fluid flow in a shaken bioreactor with conical bottom at different operating conditions Journal article; 2015; Chemical Engineering Research and Design Links: IRIS | UCL Discovery Authors: Rodriguez G,Pieralisi I,Anderlei T,Ducci A,Micheletti M click to collapse Evaluation of a structural mechanics model to predict the effect of inserts in the bed support of chromatographic columns Conference ; 2015; CHEMICAL ENGINEERING SCIENCE Links: IRIS | UCL Discovery | Author's | DOI Authors: Gerontas S,Lan T,Micheletti M,Titchener-Hooker NJ click to collapse High throughput screening of monoamine oxidase (MAO-N-D5) substrate selectivity and rapid kinetic model generation Journal article; 2015; JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC Links: IRIS | UCL Discovery | Author's | DOI Authors: Rios-Solis L,Mothia B,Yi S,Zhou Y,Micheletti M,Lye GJ click to collapse Microcarriers? suspension and flow dynamics in orbitally shaken bioreactors Journal article; 2015; Chemical Engineering Research and Design Links: IRIS | DOI | Publisher Authors: Pieralisi I,Rodriguez G,Micheletti M,Paglianti A,Ducci A click to collapse A novel microscale crossflow device for the rapid evaluation of microfiltration processes Journal article; 2014; Journal of Membrane Science Links: IRIS | UCL Discovery | DOI Authors: Rayat ACME,Lye GJ,Micheletti M click to collapse Microscale methods to rapidly evaluate bioprocess options for increasing bioconversion yields: application to the ?-transaminase synthesis of chiral amines. Journal article; 2014; Bioprocess Biosyst Eng Links: IRIS | UCL Discovery | Author's | DOI Authors: Halim M,Rios-Solis L,Micheletti M,Ward JM,Lye GJ click to collapse On the fluid dynamics of a laboratory scale single-use stirred bioreactor. Journal article; 2014; Chem Eng Sci Links: IRIS | UCL Discovery | Author's | DOI Authors: Odeleye AO,Marsh DT,Osborne MD,Lye GJ,Micheletti M click to collapse On the measurement and scaling of mixing time in orbitally shaken bioreactors Journal article; 2014; Biochemical Engineering Journal Links: IRIS | UCL Discovery | DOI Authors: Rodriguez G,Anderlei T,Micheletti M,Yianneskis M,Ducci A click to collapse TITANIUM/COBALT-DOPED PHOSPHATE GLASS MICROCARRIERS FOR BONE TISSUE ENGINEERING APPLICATIONS Conference ; 2014; WOUND REPAIR AND REGENERATION Links: IRIS | UCL Discovery | Author's Authors: Peticone C,Knowles JC,Micheletti M,Cooper-White JJ,Wall I click to collapse Evaluation of a structural mechanics model to predict the effect of inserts in the bed support of chromatographic columns Journal article; 2013; ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Links: IRIS | UCL Discovery | Author's Authors: Gerontas S,Lan T,Titchener-Hooker NJ click to collapse Mixing time and kinetic energy measurements in a shaken cylindrical bioreactor Journal article; 2013; Chemical Engineering Research and Design Links: IRIS | UCL Discovery | DOI Authors: Rodriguez G,Micheletti M,Weheliye W,Yianneskis M,Ducci A,Anderlei T click to collapse A generic hierarchical screening method for the analysis of microscale refolds using an automated robotic platform. Journal article; 2012; Biotechnol Prog Links: IRIS | UCL Discovery | Author's | DOI Authors: Ordidge GC,Mannall G,Liddell J,Dalby PA,Micheletti M click to collapse An automated microscale platform for evaluation and optimization of oxidative bioconversion processes. Journal article; 2012; Biotechnol Prog Links: IRIS | UCL Discovery | Author's | DOI Authors: Baboo JZ,Galman JL,Lye GJ,Ward JM,Hailes HC,Micheletti M click to collapse Engineering characterisation of a stirred single-use bioreactor using PIV Other; 2012; Links: IRIS | UCL Discovery Authors: Akinlolu Odeleye ,Douglas T Marsh ,Matthew Osborne ,Gary J Lye ,Martina Micheletti click to collapse How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Journal article; 2012; BIOTECHNOLOGY JOURNAL Links: IRIS | UCL Discovery | Author's | DOI Authors: Carrondo MJT,Alves PM,Carinhas N,Glassey J,Hesse F,Merten O-W,Micheletti M,Noll T,Oliveira R,Reichl U,Staby A,Teixeira AP,Weichert H,Mandenius C-F click to collapse Investigating the use of column inserts to achieve better chromatographic bed support Journal article; 2012; ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Links: IRIS | UCL Discovery | Author's Authors: Lan T,Gerontas S,Micheletti M,Titchener-Hooker N click to collapse Optical sensor enabled rocking T-flasks as novel upstream bioprocessing tools Journal article; 2012; BIOTECHNOLOGY AND BIOENGINEERING Links: IRIS | UCL Discovery | Author's | DOI Authors: Vallejos JR,Micheletti M,Brorson KA,Moreira AR,Rao G click to collapse A Multi-Disciplinary Approach Toward the Rapid and Preparative Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase /? -Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol Journal article; 2010; Organic Process Research & Development Links: IRIS | UCL Discovery Authors: Smith MEB,Chen BH,Hibbert EG,Kaulmann U,Smithies K,Galman JL,Baganz F,Dalby PA,Hailes HC,Lye GJ,Ward JM,Woodley JM,Micheletti M click to collapse Evaluation of cell disruption effects on primary recovery of antibody fragments using microscale bioprocessing techniques. Journal article; 2010; Biotechnol Prog Links: IRIS | UCL Discovery | Author's | DOI Authors: Rayat AC,Micheletti M,Lye GJ click to collapse ? ?'-Dihydroxy Ketones and 2-Amino-1,3-diols: Synthetic and Process Strategies using Biocatalysts. Journal article; 2010; Current Organic Chemistry Links: IRIS | UCL Discovery Authors: Hailes HC,Dalby PA,Lye GJ,Baganz F,Micheletti M,Szita N,Ward JM click to collapse ??,??-Dihydroxy Ketones and 2-Amino-1,3-diols: Synthetic and Process Strategies using Biocatalysts Journal article; 2010; Current Organic Chemistry Links: IRIS | UCL Discovery Authors: HAILES HC,DALBY PA,LYE GJ,BAGANZ F,MICHELETTI M,SZITA N,WARD JM click to collapse An efficient approach to bioconversion kinetic model generation based on automated microscale experimentation integrated with model driven experimental design Journal article; 2009; CHEMICAL ENGINEERING SCIENCE Links: IRIS | UCL Discovery | Author's | DOI Authors: Chen BH,Micheletti M,Baganz F,Woodley JM,Lye GJ click to collapse Hydrodynamic and oxygen mass transfer studies in a three-phase (air-water-ionic liquid) stirred tank bioreactor. Journal article; 2009; Biochemical Engineering Journal Links: IRIS | UCL Discovery Authors: Torres-Martinez D,Melgarejo-Torres R,Gutierrez-Rojas M,Aguilera-Vazquez L,Micheletti ML,G J and Huerta-Ochoa S click to collapse Microscale experiments coupled with statistical design - a smart tool for vaccine development. Conference ; 2008; Links: IRIS | UCL Discovery Authors: Mukhopadhyay TK,Islam R,Micheletti M,Lye GJ click to collapse