个人简介

2010-to date: Vice-Provost (Enterprise) 2008-2010: Head of Department of Chemistry 2003-to date: Charles Vernon Professor of Organic Chemistry and Chemical Biology 2003-2003: Professor of Chemistry, University of Sussex 1997-2002: Senior Lecturer, University of Sussex 1993-1997: Lecturer, University of Sussex 1991-1993: Lecturer, Birkbeck College, University of London 1989-1991: Post Doctoral Fellowship, Imperial College, London 1984-1986: Senior Scientific Assistant, FBC Ltd. Chesterford Park Qualifications 1986-1989: PhD. University of Southampton 1984-1986: GRSC. CCAT - Part Time 1981-1984: BSc. Chemistry. Paisley College Stephen Caddick carried out his undergraduate degree at Paisley College and then part time (GRSC) whilst working for FBC Ltd /Shering at Chesterford Park Research Station. In 1986 he moved to the University of Southampton to work with P. J. Parsons for a PhD. In 1989 he gained a PhD degree and moved to Imperial College London to work with W. B. Motherwell on alkaloid and carbohydrate synthesis. In 1991 he was appointed to a lectureship at Birkbeck College. In 1993 he moved to the University of Sussex as a lecturer (1993-1997), senior lecturer (1997-2002) and professor (2003). He joined the staff at UCL as Charles Vernon Professor of Organic Chemistry and Chemical Biology in October 2003.

研究领域

Organic Chemistry and Chemical Biology

The Caddick Research Group has a wide range of research interests cutting across synthetic organic chemistry, organometallic chemistry, medicinal chemistry, chemical biology and drug discovery. We have a multi-disciplinary laboratory of around 12 researchers with skills in molecular / cell biology, bioinformatics and synthetic chemistry, with considerable industry links. Our research interests can be divided into three broad areas of activity. 1. Discovery research and innovation in organic synthesis We are strongly committed to carrying out blue sky research in organic synthesis in which we test new concepts in organic synthesis. This is because new chemical reaction processes are vital if we are to make new molecular entities. A recent example has been our discovery that air can be used as a reagent to make carbon-carbon and carbon-nitrogen bonds. We have many areas of interest in organometallic chemistry, amino-acid chemistry, catalysis and a variety of other synthetic programmes. 2. Development of small molecule tools for applications in biology We are committed to developing new approaches for the development of tool compounds to help understand fundamental biology and to help initiate studies in medicinal chemistry. In particular our work on sulfonates and sulfonamides has been successfully applied to a number of exciting biological targets from HIV to DDAH inhibition. We have a wide range of expert collaborators and some examples of current projects include: methylarginine processing enzymes (with Dr Leiper, MRC); nuclear transport of HIV (with Dr Fassati, UCL); β-adrenergic receptor antagonists (with Drs Baker, Vinter and Tinker, UCL); epicardial stem cell differentiation (with Prof. Riley, ICH); coagulation & respiratory disease (Prof Chambers, UCL) 3. Synthetic protein chemistry and chemical mutagenesis Over the last few years we have become very interested in the power of organic synthesis for selective modification of proteins. In a very productive collaboration with Dr James Baker (UCL Chemistry) we have developed a number of new strategies for reversible and irreversible modification of proteins. Most recently we have applied this work to the development of a new GFP / FRET construct – which has been applied to cellular systems. Biological molecules are enormously important in the development of the next generation of diagnostics and therapeutics and our ability to carry out selective modification provides unique opportunities for applications in medicine and health. 4. ThioLogics – Delivering Homogeneous Protein Modification Thiologics is a UCLB-owned company spun-out of the Department of Chemistry, UCL, in June 2011. The company aims to commercialise new bioconjugation technologies developed through collaboration between our group and Dr James Baker. ThioLogics is particularly focused on delivering technology that will enable the construction of homogeneous antibody drug conjugate therapeutics (ADCs) (www.thiologics.com).

近期论文

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Boyle, R. W., Bryden, F., Maruani, A., Caddick, S., Chudasama, V., Smith, M. E., Savoie, H. (2014). Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment. Bioconjug Chem doi:10.1021/bc5000324. Author URL Browne, L. E., Nunes, J. P. M., Sim, J., Chudasama, V., Bragg, L., Caddick, S., North, R. A. (2014). Optochemical Control of Engineered Trimeric P2X Receptors and Acid-Sensing Ion Channels. BIOPHYSICAL JOURNAL. ( Vol. 106 pp.641A-641A). Author URL King, F. D., Aliev, A., Caddick, S., Tocher, D. (2014). Cyclisation reactions of N-cinnamoyl-9-aminoanthracenes. Org Biomol Chem doi:10.1039/c4ob00411f. Author URL Maruani, A., Alom, S., Canavelli, P., Lee, M. T., Morgan, R. E., Chudasama, V., Caddick, S. (2014). A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates. Chem Commun (Camb) doi:10.1039/c4cc08515a. Author URL Moody, P., Chudasama, V., Nathani, R. I., Maruani, A., Martin, S., Smith, M. E., Caddick, S. (2014). A rapid, site-selective and efficient route to the dual modification of DARPins. Chem Commun (Camb) doi:10.1039/c4cc00053f. Author URL Schumacher, F. F., Nunes, J. P., Maruani, A., Chudasama, V., Smith, M. E., Chester, K. A., Baker, J. R., Caddick, S. (2014). Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging. Org Biomol Chem doi:10.1039/c4ob01550a. Author URL Wang, Z., Lambden, S., Nandi, M., Tomlinson, J., Dyson, A., Taylor, V., Sujkovic, E., McDonald, N., Caddick, S., Singer, M., Leiper, J. (2014). A novel dimethylarginine dimethylaminohydrolase (DDAH-1) inhibitor improves survival, hemodynamics and organ function in rodent sepsis. NITRIC OXIDE-BIOLOGY AND CHEMISTRY 42, 100-100 doi:10.1016/j.niox.2014.09.010. Author URL Akhbar, A. R., Chudasama, V., Fitzmaurice, R. J., Powell, L., Caddick, S. (2013). Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones. Chem Commun (Camb) doi:10.1039/c3cc47967f. Author URL Browne, L. E., Nunes, J. P., Sim, J. A., Chudasama, V., Bragg, L., Caddick, S., Alan North, R. (2013). Optical control of trimeric P2X receptors and acid-sensing ion channels. Proc Natl Acad Sci U S A doi:10.1073/pnas.1318582111. Author URL Cal, P. M., Frade, R. F., Chudasama, V., Cordeiro, C., Caddick, S., Gois, P. M. (2013). Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates. Chem Commun (Camb) doi:10.1039/c3cc47534d. Author URL Castañeda, L., Maruani, A., Schumacher, F. F., Miranda, E., Chudasama, V., Chester, K. A., Baker, J. R., Smith, M. E., Caddick, S. (2013). Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation. Chem Commun (Camb) doi:10.1039/c3cc45220d. Author URL Castañeda, L., Wright, Z. V. F., Marculescu, C., Tran, T. M., Chudasama, V., Maruani, A., Hull, E. A., Nunes, J. P. M., Fitzmaurice, R. J., Smith, M. E. B., Jones, L. H., Caddick, S., Baker, J. R. (2013). A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones. Tetrahedron Letters 54(27), 3493-3495 Chudasama, V., Akhbar, A. R., Bahou, K. A., Fitzmaurice, R. J., Caddick, S. (2013). Metal-free, hydroacylation of CC and NN bonds via aerobic C-H activation of aldehydes, and reaction of the products thereof. Org Biomol Chem doi:10.1039/c3ob41632a. Author URL King, F. D., Aliev, A. E., Caddick, S., Tocher, D. A. (2013). The triflic acid-mediated cyclization reactions of N-cinnamoyl-1- naphthylamines. J Org Chem doi:10.1021/jo4018827. Author URL King, F. D., Caddick, S. (2013). The triflic acid-mediated cyclisation of N-benzylcinnamanilides. Tetrahedron 69(40), 8592-8601 doi:10.1016/j.tet.2013.07.075. Macmillan, D. (2013). Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins. doi:10.1002/anie.201304997. Moody, P., Burlina, F., Martin, S. R., Morgan, R. E., Offer, J., Smith, M. E., Molloy, J. E., Caddick, S. (2013). Evaluating the use of Apo-neocarzinostatin as a cell penetrating protein. Protein Eng Des Sel 26(4), 277-281 doi:10.1093/protein/gzs104. Author URL Nathani, R. I., Chudasama, V., Ryan, C. P., Moody, P. R., Morgan, R. E., Fitzmaurice, R. J., Smith, M. E., Baker, J. R., Caddick, S. (2013). Reversible protein affinity-labelling using bromomaleimide-based reagents. Org Biomol Chem 11(15), 2408-2411 doi:10.1039/c3ob40239h. Author URL Nathani, R. I., Moody, P., Chudasama, V., Smith, M. E. B., Fitzmaurice, R. J., Caddick, S. (2013). A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification. Chemical Science 2013(4), 3455-3458 doi:10.1039/C3SC51333E. Author URL Nunes, J. P. M., Afonso, C. A. M., Caddick, S. (2013). Synthesis of 2,4-bifunctionalised cyclopentenones from 2-furaldehyde. RSC Advances 3(35), 14975-14978 doi:10.1039/c3ra42663g.