Farid, Suzanne - University College London - Department of Biochemical Engineering

个人简介

Fellow of the Institution of Chemical Engineers (FIChemE) (2011-present) Royal Academy of Engineering - ExxonMobil Award for Excellence in Teaching (2009) Member of the BIA (BioIndustry Association) Manufacturing Advisory Committee for Bioprocessing Industries (2009-present) Chartered Engineer (CEng), Institution of Chemical Engineers (2007-present) Honorary Lecturer & Research Fellow at University College London (2000-2001) Member of IChemE Biochemical Engineering Subject Group, SCI Biotechnology Group (1997-present) Consultancies: e.g. Smart Analyst, Monitor Management Consultancy, CANACCORD|Adams, LEK Consulting, Bio Business Solutions Inc.

研究领域

Suzanne Farid leads research into novel computer-based decision-support tools that provide systematic foundations to help companies make better decisions where there is inevitable uncertainty in process performance, market projections and clinical success rates. The research focuses on establishing and integrating models on bioprocess economics, manufacturing logistics, dynamic simulation, uncertainty analysis, multi-objective decision-making and combinatorial optimisation. A major part of this activity is creating decision-support tools for the design of cost-effective bioprocesses. Studies in collaboration with Prof Nigel Titchener-Hooker (Biochemical Engineering), Prof John Washbrook (Computer Science) along with a consortium of companies have led to the creation of frameworks that facilitate rapid evaluation of manufacturing alternatives in terms of operational, financial and risk metrics while accounting for intrinsic complexities specific to biopharmaceutical manufacture. These tools have been used to analyse economic drivers and trade-offs in the production of the most expensive class of biopharmaceutical medicines, antibodies. These techniques are being developed further to more effectively shorten the time required to prioritise cost-effective strategies to cope with future trends. This is in collaboration with biotech and pharmaceutical companies in the new EPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies, the IMRC in Bioprocessing, Engineering Doctorate collaborations as well as TSB-funded projects. Another major focus of Suzanne’s research is in the area of creating decision-support tools for capacity planning and portfolio management. The research focuses on capturing the impact of inherent uncertainties in R&D, manufacturing and clinical trials when addressing the questions of portfolio selection, management and resource allocations. Recent work in collaboration with Dr Papageorgiou (Chemical Engineering) and Dr Yuhong Zhou (Biochemical Engineering) have created planning models specific for biopharmaceutical production that have been added to the portfolio of consultancy services of the industrial sponsor. A recently awarded TSB Technology Programme with Prof Chris Mason, Dr Farlan Veraitch and Dr Ivan Wall , is enabling research into decision-support tools that help devise successful business models for novel regenerative medicine therapies such as stem cells and cell-based vaccine cancer therapy. This is in collaboration with Lonza Biologics, UCL Dept. of Management Science & Innovation, the NHS Technology Adoption Centre, LGC and Future Medicine. Suzanne’s research also examines how best to interface experimental studies with modelling tools. Recent examples include assessing the potential of converting a waste product into a commercial product in blood plasma processing and comparing alternative manufacturing routes for the production of bio-active matrix for artificial skin substitutes. Funding for the above research has come from the UK EPSRC, the TSB Technology Programme and a range of company collaborators including Bayer, Medimmune, Pfizer, Eli Lilly, Lonza Biologics, Protherics (now BTG), Delta Biotechnology and Smith and Nephew.

近期论文

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A scale-down mimic for mapping the process performance of centrifugation, depth and sterile filtration Journal article; 2016; Biotechnology and Bioengineering Links: IRIS | UCL Discovery | DOI Authors: Joseph A,Kenty B,Mollet M,Hwang K,Rose S,Goldrick S,Bender J,Farid SS,Titchener-Hooker N click to collapse Integrated economic and experimental framework for screening of primary recovery technologies for high cell density CHO cultures Journal article; 2016; Biotechnology Journal Links: IRIS | UCL Discovery | DOI | Publisher Authors: Popova D,Stonier A,Pain D,Titchener-Hooker NJ,Farid SS click to collapse Integrated Optimization of Upstream and Downstream Processing in Biopharmaceutical Manufacturing under Uncertainty: A Chance Constrained Programming Approach Journal article; 2016; Industrial and Engineering Chemistry Research Links: IRIS | UCL Discovery | DOI Authors: Liu S,Farid SS,Papageorgiou LG click to collapse Process change evaluation framework for allogeneic cell therapies: impact on drug development and commercialization Journal article; 2016; REGENERATIVE MEDICINE Links: IRIS | UCL Discovery | Author's | DOI Authors: Hassan S,Huang H,Warren K,Mahdavi B,Smith D,Jong S,Farid SS click to collapse Allogeneic cell therapy bioprocess economics and optimization: downstream processing decisions Journal article; 2015; REGENERATIVE MEDICINE Links: IRIS | UCL Discovery | Author's | DOI Authors: Hassan S,Simaria AS,Varadaraju H,Gupta S,Warren K,Farid SS click to collapse Erratum: Allogeneic cell therapy bioprocess economics and optimization: Downstream processing decisions (Regenerative Medicine (2015) 10:5 (591-609)) Journal article; 2015; Regenerative Medicine Links: IRIS | DOI Authors: Hassan H,Simaria AS,Varadaraju H,Gupta S,Warren K,Farid SS click to collapse Human pluripotent stem cell-derived products: advances towards robust, scalable and cost-effective manufacturing strategies Journal article; 2015; Biotechnol J Links: IRIS | UCL Discovery | Author's | DOI Authors: Jenkins MJ,Farid SS click to collapse Manufacturability Indices for High-Concentration Monoclonal Antibody Formulations Journal article; 2015; 12TH INTERNATIONAL SYMPOSIUM ON PROCESS SYSTEMS ENGINEERING AND 25TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING, PT C Links: IRIS | Author's Authors: Yang Y,Velayudhan A,Thornhill NF,Farid SS click to collapse Mathematical programming approaches for downstream processing optimisation of biopharmaceuticals Journal article; 2015; CHEMICAL ENGINEERING RESEARCH & DESIGN Links: IRIS | UCL Discovery | Author's | DOI Authors: Liu S,Simaria AS,Farid SS,Papageorgiou LG click to collapse Patient-specific hiPSC bioprocessing for drug screening: Bioprocess economics and optimisation Journal article; 2015; BIOCHEMICAL ENGINEERING JOURNAL Links: IRIS | UCL Discovery | Author's | DOI Authors: Jenkins M,Bilsland J,Allsopp TE,Ho SV,Farid SS click to collapse Representative mammalian cell culture test materials for assessment of primary recovery technologies: a rapid method with industrial applicability. Journal article; 2015; Biotechnol J Links: IRIS | UCL Discovery | Author's | DOI Authors: Popova D,Stonier A,Pain D,Titchener-Hooker NJ,Farid SS click to collapse An Optimisation-based approach for biopharmaceutical manufacturing Conference ; 2014; Computer Aided Chemical Engineering Links: IRIS | UCL Discovery | DOI Authors: Liu S,Simaria AS,Farid SS,Papageorgiou LG click to collapse Capacity planning for batch and perfusion bioprocesses across multiple biopharmaceutical facilities Journal article; 2014; Biotechnology Progress Links: IRIS | UCL Discovery | DOI Authors: Siganporia CC,Ghosh S,Daszkowski T,Papageorgiou LG,Farid SS click to collapse Capacity planning for batch and perfusion bioprocesses across multiple biopharmaceutical facilities. Journal article; 2014; Biotechnol Prog Links: IRIS | UCL Discovery | Author's | DOI Authors: Siganporia CC,Ghosh S,Daszkowski T,Papageorgiou LG,Farid SS click to collapse Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture Journal article; 2014; Journal of Chemical Technology & Biotechnology Links: IRIS | UCL Discovery | DOI Authors: Allmendinger R,Simaria AS,Turner R,Farid SS click to collapse Continuous bioprocessing: The real thing this time? Journal article; 2014; mAbs Links: IRIS | UCL Discovery | DOI Authors: Farid SS,Thompson B,Davidson A click to collapse Data mining for rapid prediction of facility fit and debottlenecking of biomanufacturing facilities. Journal article; 2014; J Biotechnol Links: IRIS | UCL Discovery | Author's | DOI Authors: Yang Y,Farid SS,Thornhill NF click to collapse Evaluating the economic and operational feasibility of continuous processes for monoclonal antibodies Chapter; 2014; Links: IRIS | UCL Discovery Authors: Farid SS,Pollock J,Ho SV click to collapse Innovation in biopharmaceutical manufacture Journal article; 2014; BioProcess International Links: IRIS | UCL Discovery Authors: Davidson A,Farid SS click to collapse Large Scale Suspension Culture of Mammalian Cells Chapter; 2014; Links: IRIS | UCL Discovery Authors: Alldread RM,Birch JR,Metcalfe HK,Farid S,Racher AJ,Young RJ,Khan M click to collapse