Dalby, Paul - University College London - Department of Biochemical Engineering

个人简介

1997 PhD Doctor of Philosophy Biological Chemistry University of Cambridge 1994 MA Master of Arts Natural Sciences University of Cambridge 1993 BA Hons Bachelor of Arts (Honours) Natural Sciences University of Cambridge Paul Dalby is a Professor in Biochemical Engineering and Biotechnology at University College London, where he has been a principle investigator since April 2000. His protein engineering research aims to address key challenges in understanding protein formulation and aggregation, as well as to generate novel enzyme biocatalysts. He graduated with a Natural Sciences degree from the University of Cambridge and received his PhD in 1998, also from the University of Cambridge, for work on protein engineering and protein folding under the guidance of Sir Prof Alan Fersht. He then undertook a Postdoctoral research fellowship at the University of Philadelphia, with Bill DeGrado. Paul Dalby leads research at UCL on the application of protein engineering and biophysics in the fields of biocatalysis and biopharmaceutical manufacturing and formulation.

研究领域

Basic Life Sciences Bioprocessing Global Health Infection, Immunology & Inflammation Nanotechnology Personalised Medicine Synthetic Biology

近期论文

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Identification of Protein-Excipient Interaction Hotspots Using Computational Approaches Journal article; 2016; INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Links: IRIS | UCL Discovery | Author's | DOI Authors: Barata TS,Zhang C,Dalby PA,Brocchini S,Zloh M click to collapse Impact of cofactor-binding loop mutations on thermotolerance and activity of E-coli transketolase Journal article; 2016; ENZYME AND MICROBIAL TECHNOLOGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Morris P,Rios-Solis L,Garcia-Arrazola R,Lye GJ,Dalby PA click to collapse Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment Journal article; 2016; MOLECULAR PHARMACEUTICS Links: IRIS | UCL Discovery | Author's | DOI Authors: Chakroun N,Hilton D,Ahmad SS,Platt GW,Dalby PA click to collapse Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes Journal article; 2016; SCIENTIFIC REPORTS Links: IRIS | UCL Discovery | Author's | DOI Authors: Affaticati PE,Dai S-B,Payongsri P,Hailes HC,Tittmann K,Dalby PA click to collapse Single active-site mutants are sufficient to enhance serine:pyruvate -transaminase activity in an -transaminase Journal article; 2015; FEBS JOURNAL Links: IRIS | Author's | DOI Authors: Deszcz D,Affaticati P,Ladkau N,Gegel A,Ward JM,Hailes HC,Dalby PA click to collapse The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and Fc gamma R Ligands Journal article; 2015; JOURNAL OF BIOLOGICAL CHEMISTRY Links: IRIS | UCL Discovery | Author's | DOI Authors: Rayner LE,Hui GK,Gor J,Heenan RK,Dalby PA,Perkins SJ click to collapse Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes. Journal article; 2014; Sci Rep Links: IRIS | UCL Discovery | Author's | DOI Authors: Grant C,Deszcz D,Wei YC,Martínez-Torres RJ,Morris P,Folliard T,Sreenivasan R,Ward J,Dalby P,Woodley JM,Baganz F click to collapse The Fab conformations in the solution structure of human immunoglobulin G4 (IgG4) restrict access to its Fc region: implications for functional activity. Journal article; 2014; J Biol Chem Links: IRIS | UCL Discovery | Author's | DOI Authors: Rayner LE,Hui GK,Gor J,Heenan RK,Dalby PA,Perkins SJ click to collapse Optically induced thermal gradients for protein characterization in nanolitre-scale samples in microfluidic devices. Journal article; 2013; Sci Rep Links: IRIS | UCL Discovery | Author's | DOI Authors: Sagar DM,Aoudjane S,Gaudet M,Aeppli G,Dalby PA click to collapse Directed evolution to re-adapt a co-evolved network within an enzyme. Journal article; 2012; J Biotechnol Links: IRIS | UCL Discovery | Author's | DOI Authors: Strafford J,Payongsri P,Hibbert EG,Morris P,Batth SS,Steadman D,Smith ME,Ward JM,Hailes HC,Dalby PA click to collapse Freeze drying formulation using microscale and design of experiment approaches: a case study using granulocyte colony-stimulating factor.Journal article; 2012; Biotechnol Lett Links: IRIS | UCL Discovery | Author's | DOI Authors: Grant Y,Matejtschuk P,Bird C,Wadhwa M,Dalby PA click to collapse Transketolase catalysed upgrading of L-arabinose: the one-step stereoselective synthesis of L-gluco-heptulose Journal article; 2016; GREEN CHEMISTRY Links: IRIS | UCL Discovery | Author's | DOI Authors: Subrizi F,Cardenas-Fernandez M,Lye GJ,Ward JM,Dalby PA,Sheppard TD,Hailes HC click to collapse Modelling and optimisation of the one-pot, multi-enzymatic synthesis of chiral amino-alcohols based on microscale kinetic parameter determination Journal article; 2015; Chemical Engineering Science Links: IRIS | UCL Discovery | DOI Authors: Rios-Solis L,Morris P,Grant C,Odeleye AOO,Hailes HC,Ward JM,Dalby PA,Baganz F,Lye GJ click to collapse Second generation engineering of transketolase for polar aromatic aldehyde substrates Journal article; 2015; ENZYME AND MICROBIAL TECHNOLOGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Payongsri P,Steadman D,Hailes HC,Dalby PA click to collapse Single active-site mutants are sufficient to enhance serine:pyruvate ?-transaminase activity in an ?-transaminase Journal article; 2015; FEBS Journal Links: IRIS | DOI Authors: Deszcz D,Affaticati P,Ladkau N,Gegel A,Ward JM,Hailes HC,Dalby PA click to collapse Directed evolution to remove expression and secretion bottlenecks of heterologous enterokinase in Escherichia coli Journal article; 2014; NEW BIOTECHNOLOGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Lee W,Dalby P click to collapse Evaluation of CV2025 omega-transaminase for the bioconversion of lignin breakdown products into value-added chemicals: synthesis of vanillylamine from vanillin Journal article; 2014; BIOCATALYSIS AND BIOTRANSFORMATION Links: IRIS | UCL Discovery | Author's | DOI Authors: Du CJ,Rios-Solis L,Ward JM,Dalby PA,Lye GJ click to collapse Influence of Initial Seeding Density on Gene Expression during Neuronal Priming Journal article; 2014; Journal of Bioprocessing & Biotechniques Links: IRIS | UCL Discovery | DOI Authors: Thwaites JW,Ruban L,Mason C,Dalby P,Habib N,Jaccard N,Szita N,Wall I click to collapse The Fab conformations in the solution structure of human IgG4 restricts access to its Fc region: implications for low complement activity Conference ; 2014; MOLECULAR IMMUNOLOGY Links: IRIS | UCL Discovery | Author's Authors: Rayner LE,Hui GK,Gor J,Dalby PA,Perkins SJ click to collapse The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and complement C1q and its conformational stability. Journal article; 2013; J Mol Biol Links: IRIS | UCL Discovery | Author's | DOI Authors: Rayner LE,Kadkhodayi-Kholghi N,Heenan RK,Gor J,Dalby PA,Perkins SJ click to collapse 7.17 C-X Bond Formation: C-C Bond Formation using TDP-Dependent Enzymes Journal article; 2012; Links: IRIS | UCL Discovery | DOI Authors: Dalby PA,Ward JM,Hailes HC click to collapse A generic hierarchical screening method for the analysis of microscale refolds using an automated robotic platform. Journal article; 2012; Biotechnol Prog Links: IRIS | UCL Discovery | Author's | DOI Authors: Ordidge GC,Mannall G,Liddell J,Dalby PA,Micheletti M click to collapse A novel efficient optimisation system for purification process synthesis Journal article; 2012; Biochemical Engineering Journal Links: IRIS | UCL Discovery | DOI Authors: Polykarpou EM,Dalby PA,Papageorgiou LG click to collapse An MILP formulation for the synthesis of protein purification processes Journal article; 2012; Chemical Engineering Research and Design Links: IRIS | UCL Discovery | DOI Authors: Polykarpou EM,Dalby PA,Papageorgiou LG click to collapse Effect of low pH viral inactivation conditions on the solution structure of antibody Conference ; Links: IRIS | UCL Discovery Authors: Dalby PA