Baganz, Frank - University College London - Department of Biochemical Engineering

个人简介

1997 PhD Doctor of Philosophy Yeast Molecular Biology and Fermentation University of Manchester Institute of Science and Technology 1994 Dipl. Ing. Diplom- Ingenieur Biotechnology and Biochemical Engineering Fachhochschule Ostfriesland, Emden

研究领域

Frank’s research is focused on modelling, engineering and scale-up/down of fermentation, cell culture and biocatalytic processes. A major aim of the research is to mimic the environmental conditions that the cells are exposed to at the large/industrial scale in miniature bioreactor systems in order to better understand the cell response and thereby improve the manufacturing process using computer simulations and experimental approaches. In collaboration with Professor Gary Lye, he pioneered the use of microwell-based techniques to acquire information about fermentation and bioconversion. In particular, he established the engineering fundamentals of mixing and oxygen transfer in microwells and developed novel miniaturised bioreactors. His research also demonstrated the feasibility of predictive scale up from micro/mini reactors to lab scale reactors using established methods. He continues this work as part of the IMRC in Bioprocessing where he developed a platform for scale-down of industrial fermentation and cell culture processes in miniature bioreactors and microwells. In recognition for his contributions to this area he received the 2010 Pharmaceuticals Division Plenary Award of the AIChE. The micro/mini bioreactor work is complemented by detailed characterisation of fermentation and cell culture processes at lab scale and its integration with downstream processing for processing of macromolecules. Frank is a co-investigator of the multi-faculty Bioconversion-Chemistry-Engineering Interface programme (BiCE) led by Prof. Gary Lye that is concerned with the development of novel tools integrating chemistry, biology and engineering to accelerate development of biocatalytic processes. The main focus of his research is on modelling and optimisation of enzyme-catalysed reactions and construction of de novo pathways for synthesis of complex chiral molecules. To enable this he developed an immobilised enzyme microreactor for rapid determination of enzyme kinetics and analysis of de novo pathways. One of the aims is to identify enzyme combinations for integration into whole cell systems that could be used for industrial applications. The metabolic engineering of the whole cell biocatalysts is carried out in collaboration with Professor John Ward (Institute of Structural and Molecular Biology) and Dr Darren Nesbeth. The enginering work is aided by use of microwell approaches and statistical experimental design methods to identify process bottlenecks. Recently he established research in the area of algal biotechnology. Working in close collaboration with Dr Saul Purton (ISMB) he is assessing the potential of microalgae for recombinant protein synthesis and the production and recovery of biofuels using scale-down approaches for cell and process characterisation. Funding for the above research has come from the UK BBSRC, EPSRC and a range of company collaborators

近期论文

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Real-time pH monitoring of industrially relevant enzymatic reactions in a microfluidic side-entry reactor (?SER) shows potential for pH control Journal article; 2017; Biotechnology Journal Links: IRIS | UCL Discovery | DOI Authors: Gruber P,Marques MPC,Sulzer P,Wohlgemuth R,Mayr T,Baganz F,Szita N click to collapse Algal biomass and diesel emulsions: An alternative approach for utilizing the energy content of microalgal biomass in diesel engines Journal article; 2016; APPLIED ENERGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Xu Y,Hellier P,Purton S,Baganz F,Ladommatos N click to collapse Mixing Time as a Criterion for Scale Translation of Cell-Culture Processes Journal article; 2016; BIOPHARM INTERNATIONAL Links: IRIS | Author's Authors: Sani MH,Baganz F click to collapse Modulating the import of medium-chain alkanes in E. coli through tuned expression of FadL Journal article; 2016; JOURNAL OF BIOLOGICAL ENGINEERING Links: IRIS | UCL Discovery | Author's | DOI Authors: Call TP,Akhtar MK,Baganz F,Grant C click to collapse Design and parallelisation of a miniature photobioreactor platform for microalgal culture evaluation and optimisation Journal article; 2015; BIOCHEMICAL ENGINEERING JOURNAL Links: IRIS | UCL Discovery | Author's | DOI Authors: Ojo EO,Auta H,Baganz F,Lye GJ click to collapse DEVELOPMENT OF pH STABLE MEDIA FOR PHOTOTROPHIC AND HETEROTROPHIC CULTIVATION OF CHLORELLA SOROKINIANA Journal article; 2015; EUROPEAN JOURNAL OF PHYCOLOGY Links: IRIS | Author's Authors: Ojo EO,Auta H,Baganz F,Lye GJ click to collapse Improving recombinant protein production in the Chlamydomonas reinhardtii chloroplast using vivid Verde Fluorescent Protein as a reporter Journal article; 2015; BIOTECHNOLOGY JOURNAL Links: IRIS | Author's | DOI Authors: Braun-Galleani S,Baganz F,Purton S click to collapse Micropillar-Based Aqueous-Organic Continuous Liquid-Liquid Extraction Device Conference ; Links: IRIS Authors: Chiang ,Dimov N,Marques MP,Baganz F,Szita N click to collapse Modelling and optimisation of the one-pot, multi-enzymatic synthesis of chiral amino-alcohols based on microscale kinetic parameter determination Journal article; 2015; CHEMICAL ENGINEERING SCIENCE Links: IRIS | UCL Discovery | Author's | DOI Authors: Rios-Solis L,Morris P,Grant C,Odeleye AOO,Hailes HC,Ward JM,Dalby PA,Baganz F,Lye GJ click to collapse Multi-step biocatalytic strategies for chiral amino alcohol synthesis Journal article; 2015; ENZYME AND MICROBIAL TECHNOLOGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Villegas-Torres MF,Martinez-Torres RJ,Cazares-Koerner A,Hailes H,Baganz F,Ward J click to collapse Bacterial growth modeling for rapid fermentation process development using a parallel mini-bioreactor system Journal article; 2014; NEW BIOTECHNOLOGY Links: IRIS | Author's | DOI Authors: Erbas A,Allman T,Baganz F click to collapse Combined remediation and lipid production using Chlorella sorokiniana grown on wastewater and exhaust gases. Journal article; 2014; Bioresour Technol Links: IRIS | UCL Discovery | Author's | DOI Authors: Lizzul AM,Hellier P,Purton S,Baganz F,Ladommatos N,Campos L click to collapse Engineering characterisation of a shaken, single-use photobioreactor for early stage microalgae cultivation using Chlorella sorokiniana. Journal article; 2014; Bioresour Technol Links: IRIS | UCL Discovery | Author's | DOI Authors: Ojo EO,Auta H,Baganz F,Lye GJ click to collapse Exploring the potential of microalgae as a source for bioenergy production Journal article; 2014; Links: IRIS | UCL Discovery Authors: Xu Y Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes. Journal article; 2014; Sci Rep Links: IRIS | UCL Discovery | Author's | DOI Authors: Grant C,Deszcz D,Wei YC,Martínez-Torres RJ,Morris P,Folliard T,Sreenivasan R,Ward J,Dalby P,Woodley JM,Baganz F click to collapse Impact of aeration strategies on fed-batch cell culture kinetics in a single-use 24-well miniature bioreactor Journal article; 2014; BIOCHEMICAL ENGINEERING JOURNAL Links: IRIS | UCL Discovery | Author's | DOI Authors: Betts JPJ,Warr SRC,Finka GB,Uden M,Town M,Janda JM,Baganz F,Lye GJ click to collapse Microscale tools for evaluating the biological and process options of alkane biooxidations Journal article; 2014; NEW BIOTECHNOLOGY Links: IRIS | Author's | DOI Authors: Kolmar J,Baganz F,Engel P click to collapse Recombinant protein expression in the chloroplast of the green microalga Chlamydomonas reinhardtii: A case study using a novel green fluorescent protein as a reporter Journal article; 2014; NEW BIOTECHNOLOGY Links: IRIS | Author's | DOI Authors: Galleani SB,Baganz F,Purton S click to collapse Use of transporter plug-ins in building effective microbial cell factories for chemical and fuel production Journal article; 2014; NEW BIOTECHNOLOGY Links: IRIS | Author's | DOI Authors: Grant C,Morris P,Baganz F click to collapse Characterization and multi-step transketolase-?-transaminase bioconversions in an immobilized enzyme microreactor (IEMR) with packed tube. Journal article; 2013; J Biotechnol Links: IRIS | UCL Discovery | Author's | DOI Authors: Halim AA,Szita N,Baganz F click to collapse Chitosan flocculation to aid the harvesting of the microalga Chlorella sorokiniana Journal article; 2013; BIORESOURCE TECHNOLOGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Xu Y,Purton S,Baganz F click to collapse ENGINEERING CHARACTERIZATION OF A SHAKEN MICRO-BIOREACTOR PLATFORM FOR PARALLEL EVALUATION OF MICROALGAE CULTIVATION AND SCALE-UP Journal article; 2013; PHYCOLOGIA Links: IRIS | UCL Discovery | Author's Authors: Ojo EO,Auta H,Baganz F,Lye GJ click to collapse Non-linear kinetic modelling of reversible bioconversions: Application to the transaminase catalyzed synthesis of chiral amino-alcohols Journal article; 2013; BIOCHEMICAL ENGINEERING JOURNAL Links: IRIS | UCL Discovery | Author's | DOI Authors: Rios-Solis L,Bayir N,Halim M,Du C,Ward JM,Baganz F,Lye GJ click to collapse Characterization and feasibility of a miniaturized stirred tank bioreactor to perform E. coli high cell density fed-batch fermentations. Journal article; 2012; Biotechnol Prog Links: IRIS | UCL Discovery | Author's | DOI Authors: Ali S,Perez-Pardo MA,Aucamp JP,Craig A,Bracewell DG,Baganz F click to collapse