Tachtsidis, Ilias - University College London - Department of medical physics and biomedical engineering

个人简介

Dr Tachtsidis is a Wellcome Trust Senior Fellow and Reader in Biomedical Engineering. He is a senior member of the Biomedical Optics Research Laboratory and heads the Multi-Modal Spectroscopy Group. His research is highly multi-disciplinary, crossing the boundaries between engineering, physics, neuroscience and clinical medicine. The technical focus of his work is the development and use of non-invasive optical instruments and techniques for monitoring brain oxygenation, haemodynamics and metabolism. A major part of Dr Tachtsidis research is to investigate the use and limitations of functional Near-Infrared Spectroscopy or fNIRS in neuroscience applications. In addition, the clinical focus of his work is the identification and use of optically measured biomarkers to assess the functional status of the brain. The principal challenge of his research is the non-invasive measurement, with NIRS, of cytochrome-c-oxidase (CCO), a mitochondrial enzyme responsible for cellular energy production. Dr Tachtsidis and his team have developed unique NIRS systems that currently are used at UCL Hospitals in London, to monitor adult traumatic-brain-injury patients and birth asphyxiated infants. He has long term collaborations with industry that includes Hitachi and Hamamatsu Photonics.

研究领域

Biomedical optics. Near-infared Spectroscopy Multimodal brain imaging through combination of MR and NIRS. Development of time-resolved and broadband photonic systems to monitor the brain tissue. Monitoring brain functional activation with NIRS. Investigation of brain autoregulation using signal processing techniques. Development of mathematical models of brain physiology using a systems biology approach.

近期论文

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Mitra, S., Bale, G., Mathieson, S., Uria-Avellanal, C., Meek, J., Tachtsidis, I., & Robertson, N. J. (2016). Changes in Cerebral Oxidative Metabolism during Neonatal Seizures Following Hypoxic-Ischemic Brain Injury. Frontiers in pediatrics, 4, 83. doi:10.3389/fped.2016.00083 Kleiser, S., Pastewski, M., Hapuarachchi, T., Hagmann, C., Fauchere, J. -. C., Tachtsidis, I., . . . Scholkmann, F. (2016). Characterizing Fluctuations of Arterial and Cerebral Tissue Oxygenation in Preterm Neonates by Means of Data Analysis Techniques for Nonlinear Dynamical Systems. OXYGEN TRANSPORT TO TISSUE XXXVII, 876, 511-519. doi:10.1007/978-1-4939-3023-4_64 de roever, I., Bale, G. M., cooper, R., & tachtsidis, I. (2016). Cytochrome-C-Oxidase Exhibits Higher Brain-Specificity than Haemoglobin in Functional Activation. Caicedo, A., Varon, C., Hunyadi, B., Papademetriou, M., Tachtsidis, I., & Van Huffel, S. (2016). Decomposition of Near-Infrared Spectroscopy Signals Using Oblique Subspace Projections: Applications in Brain Hemodynamic Monitoring. FRONTIERS IN PHYSIOLOGY, 7, ARTN 515. doi:10.3389/fphys.2016.00515 Bale, G. M. (2016). Development of optical instrumentation and methods to monitor brain oxygen metabolism: application to neonatal brain injury (Doctoral dissertation). University College London. Bale, G. M. (2016). Development of optical instrumentation and methods to monitor brain oxygen metabolism: application to neonatal brain injury (Doctoral dissertation). University College London. Tachtsidis, I., & Scholkmann, F. (2016). False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward. Neurophotonics, 3 (3), 031405-?. Bale, G., Elwell, C. E., & Tachtsidis, I. (2016). From Jobsis to the present day: a review of clinical near-infrared spectroscopy measurements of cerebral cytochrome-c-oxidase (vol 21, 091307, 2016). JOURNAL OF BIOMEDICAL OPTICS, 21 (9), ARTN 099801. doi:10.1117/1.JBO.21.9.099801 Bale, G., Elwell, C. E., & Tachtsidis, I. (2016). From Jöbsis to the present day: A review of clinical near-infrared spectroscopy measurements of cerebral cytochrome-c-oxidase. Journal of Biomedical Optics, 21 (9). doi:10.1117/1.JBO.21.9.091307 Ghosh, A., Highton, D., Kolyva, C., Tachtsidis, I., Elwell, C. E., & Smith, M. (2016). Hyperoxia results in increased aerobic metabolism following acute brain injury. J Cereb Blood Flow Metab. doi:10.1177/0271678X16679171 Chisholm, K. I., Ida, K. K., Davies, A. L., Papkovsky, D. B., Singer, M., Dyson, A., . . . Smith, K. J. (2016). In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue. OXYGEN TRANSPORT TO TISSUE XXXVII, 876, 233-239. doi:10.1007/978-1-4939-3023-4_29 Bale, G. M., mitra, S., meek, J., mathieson, S., uria, C., kendall, G., . . . tachtsidis, I. (2016). In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke. null (pp. 493-499). Kluwer (now part of Springer). Broad, K. D., Fierens, I., Fleiss, B., Rocha-Ferreira, E., Ezzati, M., Hassell, J., . . . Robertson, N. J. (2016). Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia. NEUROBIOLOGY OF DISEASE, 87, 29-38. doi:10.1016/j.nbd.2015.12.001 Caldwell, M., Scholkmann, F., Wolf, U., Wolf, M., Elwell, C., & Tachtsidis, I. (2016). Modelling confounding effects from extracerebral contamination and systemic factors on functional near-infrared spectroscopy. NeuroImage, 143, 91-105. doi:10.1016/j.neuroimage.2016.08.058 Phan, P. T., Highton, D., Lai, J., Smith, M., Elwell, C., & Tachtsidis, I. (2016). Multi-channel multi-distance broadband nearinfrared spectroscopy system to measure the spatial response of cellular oxygen metabolism and tissue oxygenation. Biomedical Optics Express. doi:10.1364/BOE.7.004424 Highton, D., Tachtsidis, I., Tucker, A., Elwell, C., & Smith, M. (2016). Near Infrared Light Scattering Changes Following Acute Brain Injury. OXYGEN TRANSPORT TO TISSUE XXXVII, 876, 139-144. doi:10.1007/978-1-4939-3023-4_17 Kaynezhad, P., Tachtsidis, I., & Jeffery, G. (2016). Optical monitoring of retinal respiration in real time: 670 nm light increases the redox state of mitochondria. Experimental eye research. doi:10.1016/j.exer.2016.09.006 Bale, G. M., mitra, S., meek, J., robertson, N., & tachtsidis, I. (2016). Relationship Between Cerebral Cytochrome-C-Oxidase and Oxygenation is Associated with Brain Injury Severity in Birth Asphyxiated Infants. Hapuarachchi, T., Scholkmann, F., Caldwell, M., Hagmann, C., Kleiser, S., Metz, A. J., . . . Tachtsidis, I. (2016). Simulation of Preterm Neonatal Brain Metabolism During Functional Neuronal Activation Using a Computational Model. OXYGEN TRANSPORT TO TISSUE XXXVII, 876, 111-120. doi:10.1007/978-1-4939-3023-4_14 Phan, P., Highton, D., Brigadoi, S., Tachtsidis, I., Smith, M., & Elwell, C. E. (2016). Spatial distribution of changes in oxidised cytochrome C oxidase during visual stimulation using broadband near infrared spectroscopy imaging. Advances in Experimental Medicine and Biology, 923, 195-201. doi:10.1007/978-3-319-38810-6_26 Chitnis, D., Airantzis, D., Highton, D., Williams, R., Phan, P., Giagka, V., . . . Everdell, N. (2016). Towards a wearable near infrared spectroscopic probe for monitoring concentrations of multiple chromophores in biological tissue in vivo. Review of Scientific Instruments. doi:10.1063/1.4954722 Caldwell, M., Hapuarachchi, T., Highton, D., Elwell, C., Smith, M., & Tachtsidis, I. (2015). BrainSignals Revisited: Simplifying a Computational Model of Cerebral Physiology. PLOS ONE, 10 (5), ARTN e0126695. doi:10.1371/journal.pone.0126695 Mitra, S., Bale, G., Mathieson, S., Uria-Avellanal, C., Meek, J., Tachtsidis, I., & Robertson, N. J. (n.d.). Cerebral mitochondrial oxidative metabolism is closely related to electrographic changes during recurrent neonatal seizures following hypoxic-ischaemic encephalopathy. Mitra, S., Bale, G., Mathieson, S., Uria-Avellanal, C., Meek, J., Tachtsidis, I., & Robertson, N. J. (2015). Changes in cerebral oxidative metabolism during recurrent neonatal seizures. Andreadou, M., Liandris, E., Gazouli, M., Mataragka, A., Tachtsidis, I., Goutas, N., . . . Ikonomopoulos, J. (2015). Detection of Leishmania-specific DNA and surface antigens using a combination of functionalized magnetic beads and cadmium selenite quantum dots. Journal of Microbiological Methods, 123, 62-67. doi:10.1016/j.mimet.2015.11.019