Bertazzo, Sergio - University College London - Department of medical physics and biomedical engineering

个人简介

Dr Bertazzo joined the Department of Medical Physics & Biomedical Engineering after a Junior Research Fellowship at Imperial College London, a postdoctoral stay in Germany and another in Brazil. He has been working for long time now with different electron microscopes and developed several new methods to prepare and image cells and, more particularly, calcified tissues. His research has so far been able to physicochemically describe how hydroxyapatite (i.e. the calcium phosphate that forms bone and teeth) behaves in biological fluids; determine the nature of the mineral present in cardiovascular calcification (e.g. in atherosclerosis, aortic valve stenosis and rheumatic fever); correlate different kinds of microscopy; and, finally, identify the possibility of preservation of organic materials in fossils that were not exceptionally preserved.

研究领域

Mineralomics, specifically: Pathological calcification Biomineralization Bio-imaging Palaeontology

近期论文

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Hutcheson, J. D., Goettsch, C., Bertazzo, S., Maldonado, N., Ruiz, J. L., Goh, W., . . . Aikawa, E. (2016). Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. NATURE MATERIALS, 15 (3), 335-+. doi:10.1038/NNIAT4519 Agarwal, S., & Bertazzo, S. (2016). New paradigms in cardiovascular calcification. Comptes Rendus Chimie, 19 (11-12), 1605-1609. doi:10.1016/j.crci.2015.09.013 Bertazzo, S., Maidment, S. C. R., Kallepitis, C., Fearn, S., Stevens, M. M., & Xie, H. -. N. (2015). Fibres and cellular structures preserved in 75-million-year-old dinosaur specimens (vol 6, 7352, 2015). NATURE COMMUNICATIONS, 6, ARTN 7352. doi:10.1038/ncomms8352 Hembury, M., Chiappini, C., Bertazzo, S., Kalber, T. L., Drisko, G. L., Ogunlade, O., . . . Stevens, M. M. (2015). Gold-silica quantum rattles for multimodal imaging and therapy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112 (7), 1959-1964. doi:10.1073/pnas.1419622112 Horejs, C. M., Serio, A., Purvis, A., Gormley, A. J., Bertazzo, S., Poliniewicz, A., . . . Stevens, M. M. (2014). Biologically-active laminin-111 fragment that modulates the epithelial-to-mesenchymal transition in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America, 111 (16), 5908-5913. doi:10.1073/pnas.1403139111 Bertazzo, S., Steele, J. A. M., Chester, A. H., Yacoub, M. H., & Stevens, M. M. (2014). Cardiovascular calcification violet pearl. The Lancet, 384 (9950), 1294-?. doi:10.1016/S0140-6736(13)62369-7 Bertazzo, S., Gentleman, E., Cloyd, K. L., Chester, A. H., Yacoub, M. H., & Stevens, M. M. (2013). Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification. Nature Materials, 12 (6), 576-583. doi:10.1038/nmat3627 Bertazzo, S., Zambuzzi, W. F., Campos, D. D. P., Ogeda, T. L., Ferreira, C. V., & Bertran, C. A. (2010). Hydroxyapatite surface solubility and effect on cell adhesion. Colloids and Surfaces B: Biointerfaces, 78 (2), 177-184. doi:10.1016/j.colsurfb.2010.02.027 Bertazzo, S., & Gentleman, E. (n.d.). Aortic valve calcification: a bone of contention. European Heart Journal, ehw071. doi:10.1093/eurheartj/ehw071 Bertazzo, S. (2016). Cardiovascular calcification and hard sciences: a solid match [Digital scholarly resource]. Retrieved from http://isacb.org/scientific-profile-by-sergio-bertazzo. Krohn, J. B., Hutcheson, J. D., Martinez-Martinez, E., Irvin, W. S., Bouten, C. V. C., Bertazzo, S., . . . Aikawa, E. (2016). Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-beta Signaling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36 (3), 525-533. doi:10.1161/ATVBAHA.115.307009 Wickham, A., Vagin, M., Khalaf, H., Bertazzo, S., Hodder, P., Dånmark, S., . . . Aili, D. (2016). Electroactive biomimetic collagen-silver nanowire composite scaffolds. Nanoscale, 8 (29), 14146-14155. doi:10.1039/c6nr02027e Maçon, A. L. B., Jacquemin, M., Page, S. J., Li, S., Bertazzo, S., Stevens, M. M., . . . Jones, J. R. (2016). Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships. Journal of Sol-Gel Science and Technology, 1-11. doi:10.1007/s10971-016-4097-x Lattuada, M., Ren, Q., Zuber, F., Galli, M., Bohmer, N., Matter, M. T., . . . Herrmann, I. K. (2016). Theranostic body fluid cleansing: rationally designed magnetic particles enable capturing and detection of bacterial pathogens. JOURNAL OF MATERIALS CHEMISTRY B, 4 (44), 7080-7086. doi:10.1039/c6tb01272h Belu, A., Schnitker, J., Bertazzo, S., Neumann, E., Mayer, D., Offenhaeusser, A., & Santoro, F. (2016). Ultra-thin resin embedding method for scanning electron microscopy of individual cells on high and low aspect ratio 3D nanostructures. JOURNAL OF MICROSCOPY, 263 (1), 78-86. doi:10.1111/jmi.12378 Bertazzo, S. (2015). Bio-medical physical sciences – a personal perspective on interdisciplinary research [Digital scholarly resource]. Retrieved from http://www.materialstoday.com/biomaterials/comment/biomedical-physical-sciences-a-perspective/. Bertazzo, S. (2015). Biomineralization. Seminars in Cell and Developmental Biology, 46, 1-?. doi:10.1016/j.semcdb.2015.11.010 Bazin, D., Jouanneau, C., Bertazzo, S., Sandt, C., Dessombz, A., Réfrégiers, M., . . . Daudon, M. (2015). Combining field effect scanning electron microscopy, deep UV fluorescence, Raman, classical and synchrotron radiation Fourier transform Infra-Red Spectroscopy in the study of crystal-containing kidney biopsies. Comptes Rendus Chimie, 19 (11-12), 1439-1450. doi:10.1016/j.crci.2015.03.001 Herrmann, I. K., Bertazzo, S., O'Callaghan, D. J. P., Schlegel, A. A., Kallepitis, C., Antcliffe, D. B., . . . Stevens, M. M. (2015). Differentiating sepsis from non-infectious systemic inflammation based on microvesicle-bacteria aggregation. Nanoscale, 7 (32), 13511-13520. doi:10.1039/c5nr01851j Kapustin, A. N., Kalinina, N., Lopatina, T., Davidson, S. M., Iraci, N., Tamkovich, S., . . . Tkachuk, V. (2015). UK-Russia Researcher Links Workshop: extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1-5 March 2015. Journal of extracellular vesicles, 4, 28094-?. Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., . . . Shanahan, C. M. (2015). Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion. CIRCULATION RESEARCH, 116 (8), 1312-1323. doi:10.1161/CIRCRESAHA.116.305012 Nair, R., Santos, L., Awasthi, S., Von Erlach, T., Chow, L. W., Bertazzo, S., & Stevens, M. M. (2014). Extracellular vesicles derived from preosteoblasts influence embryonic stem cell differentiation. Stem Cells and Development, 23 (14), 1625-1635. doi:10.1089/scd.2013.0633 Gemini-Piperni, S., Milani, R., Bertazzo, S., Peppelenbosch, M., Takamori, E. R., Granjeiro, J. M., . . . Zambuzzi, W. (2014). Kinome profiling of osteoblasts on hydroxyapatite opens new avenues on biomaterial cell signaling. Biotechnology and Bioengineering, 111 (9), 1900-1905. doi:10.1002/bit.25246 De La Rica, R., Bat, E., Herpoldt, K. L., Xie, H. N., Bertazzo, S., Maynard, H. D., & Stevens, M. M. (2014). Nanoparticle growth via concentration gradients generated by enzyme nanopatterns. Advanced Functional Materials, 24 (24), 3692-3698. doi:10.1002/adfm.201304047 Chow, L. W., Armgarth, A., St-Pierre, J. P., Bertazzo, S., Gentilini, C., Aurisicchio, C., . . . Stevens, M. M. (2014). Peptide-directed spatial organization of biomolecules in dynamic gradient scaffolds. Advanced Healthcare Materials, 3 (9), 1381-1386. doi:10.1002/adhm.201400032