Leung, Terence - University College London - Department of medical physics and biomedical engineering

个人简介

After receiving my BEng in Electromechanical Engineering at Southampton University, I started my PhD study in the Institute of Sound and Vibration Research at the same university. The program was initially funded by then Defence Research Agency (now QinetiQ) to develop a signal processing algorithm to detect sea vessels and submarines based on sonar signals. I later switched to a new topic on automatic heart sound classification, collaborating with cardiologists in Southampton General Hospital. Shortly after PhD graduation, I joined the Biomedical Optics Research Laboratory within the Department of Medical Physics and Bioengineering at UCL as a Research Associate in 2001. Between 2001 and 2008, I was funded by the Wellcome Trust and Hamamatu Photonics KK to work on biomedical applications of near infrared spectroscopy to measure oxygenation and perfusion in adult/neonatal brains and muscle. In 2008, I was awarded the EPSRC Career Acceleration Fellowship to investigate acousto-optics for clinical monitoring.

研究领域

My main research involves the investigation of the interaction between light and sound, more specifically how acoustic waves influence the way light travels, a technique known as acousto-optics. My aim is to apply acousto-opitc techniques for clinical monitoring. We are developing a new acousto-optic probe which exploits focused ultrasound and near infrared light to measure regional oxygenation in the brain and muscle. Because of its focusing capability, the acousto-optic probe should provide a more accurate oxygenation measurement than the current optical techniques. To understand the physics behind experimental observations, we have developed computer models for the interaction between light and sound based on Monte Carlo simulations and the Diffusion Equation. These models form a crucial part of an image reconstruction algorithm which will allow us to use acousto-optic data to reconstruct 3D images of oxygenation in organs such as the breast. We are also investigating the use of microbubbles, a clinical ultrasound agent, as a scattering contrast agent for optical monitoring. This technique may allow us to measure venous oxygen saturation in the jugular vein in the future. I am also interested in developing mobile phone Apps for physiological monitoring and healthcare applications, e.g., a cycling App for measuring a cyclist’s work output and an App to identify jaundice in newborn babies.

近期论文

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Banerjee, J., Leung, T. S., & Aladangady, N. (2016). Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow. Vox sanguinis. doi:10.1111/vox.12436 Banerjee, J., Leung, T. S., & Aladangady, N. (2016). Effect of blood transfusion on intestinal blood flow and oxygenation in extremely preterm infants during first week of life. Transfusion, 56 (4), 808-815. doi:10.1111/trf.13434 Powell, S., Arridge, S. R., & Leung, T. S. (2016). Gradient-Based Quantitative Image Reconstruction in Ultrasound-Modulated Optical Tomography: First Harmonic Measurement Type in a Linearised Diffusion Formulation. IEEE Transactions on Medical Imaging, 35 (2), 456-467. doi:10.1109/TMI.2015.2478742 Al-Armaghany, A., Tong, K., Highton, D., & Leung, T. S. (2016). Validation of a Hybrid Microwave-Optical Monitor to Investigate Thermal Provocation in the Microvasculature. In C. E. Elwell, T. S. Leung, D. K. Harrison (Eds.), null (pp. 435-441). SPRINGER. doi:10.1007/978-1-4939-3023-4_55 Banerjee, J., Leung, T. S., & Aladangady, N. (2015). Cerebral blood flow and oximetry response to blood transfusion in relation to chronological age in preterm infants. Early human development, 97, 1-8. doi:10.1016/j.earlhumdev.2015.10.017 Powell, S., Arridge, S. R., & Leung, T. S. (2015). First-harmonic sensitivity functions for a linearised diffusion model of ultrasound-modulated optical tomography. PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2015, 9323, ARTN 932342. doi:10.1117/12.2077435 Leung, T. S., Kapur, K., Guilliam, A., Okell, J., Lim, B., MacDonald, L. W., & Meek, J. (2015). Screening neonatal jaundice based on the sclera color of the eye using digital photography. Biomedical Optics Express, 6 (11), 4529-4538. doi:10.1364/BOE.6.004529 Al-Armaghany, A., Tong, K., & Leung, T. S. (2014). Development of a hybrid microwave-optical thermoregulation monitor for the muscle. null (pp. 347-353). doi:10.1007/978-1-4939-0620-8_46 Robertson, J. L., Ghosh, A., Correia, T., Highton, D., Smith, M., Elwell, C. E., & Leung, T. S. (2014). Effect of blood in the cerebrospinal fluid on the accuracy of cerebral oxygenation measured by near infrared spectroscopy. null (pp. 233-240). doi:10.1007/978-1-4939-0620-8_31 Powell, S., & Leung, T. S. (2014). Quantitative reconstruction of absorption and scattering coefficients in ultrasound-modulated optical tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8943. doi:10.1117/12.2039770 Gunadi, S., Leung, T. S., Elwell, C. E., & Tachtsidis, I. (2014). Spatial sensitivity and penetration depth of three cerebral oxygenation monitors. Biomedical Optics Express, 5 (9), 2896-2912. doi:10.1364/BOE.5.002896 Leung, T., Panainte, R., Shah, V., Taneja, D., & Mohamedally, D. (2014). The UCL Jaundice in Children Research app. Presented at: UCL. Leung, T. S., & Jiang, S. (2013). Acousto-optic imaging of a color picture hidden behind a scattering layer. Optics Express, 21 (22), 26780-26785. doi:10.1364/OE.21.026780 Leung, T. S., & Jiang, S. (2013). Classifying hidden colors behind an opaque layer with the acoustically modulated laser speckle contrast technique. Optics Express, 21 (17), 20197-20209. doi:10.1364/OE.21.020197 Al-Armaghany, A., Tong, K., & Leung, T. S. (2013). Development of a hybrid microwave-optical tissue oxygenation probe to measure thermal response in the deep tissue. Advances in Experimental Medicine and Biology, 789, 371-377. doi:10.1007/978-1-4614-7411-1-49 Al-Armaghany, A., Tong, K., & Leung, T. S. (2013). Development of a hybrid microwave-optical tissue oxygenation probe to measure thermal response in the deep tissue. Adv Exp Med Biol, 789, 371-377. doi:10.1007/978-1-4614-7411-1_49 Powell, S., & Leung, T. S. (2013). Image reconstruction techniques for ultrasound-modulated optical tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8578. doi:10.1117/12.2001857 Amiri, A. R., Craggs, M. D., Casey, A. T. H., Lee, C. H., Leung, T. S., & Hetreed, M. (2013). Intraoperative assessment of human spinal cord perfusion using near infrared spectroscopy with indocyanine green tracer technique. Spine Journal. doi:10.1016/j.spinee.2013.05.054 Leung, T. S., Honeysett, J. E., Stride, E., & Deng, J. (2013). Light propagation in a turbid medium with insonified microbubbles. J Biomed Opt, 18 (1), 15002-?. doi:10.1117/1.JBO.18.1.015002 Powell, S., & Leung, T. S. (2013). Linear reconstruction of absorption perturbations in coherent ultrasound-modulated optical tomography. Journal of Biomedical Optics, 18 (12). doi:10.1117/1.JBO.18.12.126020 Leung, T. S., & Jiang, S. (2013). Seeing hidden colors with acoustically modulated laser speckle sensing. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8581. doi:10.1117/12.2004620 Al-Armaghany, A., Tong, K., & Leung, T. S. (2013). Superficial heat reduction technique for a hybrid microwave-optical device. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 3749-3752. doi:10.1109/EMBC.2013.6610359 Powell, S., & Leung, T. S. (2012). Acousto-optic monitoring of high-intensity focused ultrasound lesion formation with fibre-coupled autocorrelation detection. Proceedings of Meetings on Acoustics, 15. doi:10.1121/1.4803866 Honeysett, J. E., Stride, E., Deng, J., & Leung, T. S. (2012). An algorithm for sensing venous oxygenation using ultrasound-modulated light enhanced by microbubbles. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8223. doi:10.1117/12.907952 Honeysett, J. E., Stride, E., & Leung, T. S. (2012). Feasibility study of non-invasive oxygenation measurement in a deep blood vessel using acousto-optics and microbubbles. Advances in Experimental Medicine and Biology, 737, 277-283. doi:10.1007/978-1-4614-1566-4_41