Shmueli, Karin - University College London - Department of medical physics and biomedical engineering

研究领域

I am interested in developing Magnetic Resonance Imaging (MRI) techniques to increase image contrast and resolution by exploiting new contrast mechanisms. The current goal of my research programme is to characterise frequency and susceptibility contrasts and to develop and translate MRI techniques exploiting these mechanisms to improve disease diagnosis and monitoring of therapies. Conventional MRI uses only the signal magnitude, but utilising the frequency (or phase) of the MRI signal has dramatically improved visualisation of tissue structure and can reveal tissue composition. During my previous post at the USA National Institutes of Health, I developed new methods to calculate tissue magnetic susceptibility maps from MRI frequency images. MRI tissue Susceptibility Mapping is an exciting technique and a rapidly growing research area. Together with my research group and collaborators, I now aim to unlock the potential of these MRI frequency and susceptibility methods to generate clinical MRI biomarkers of disease.

近期论文

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Biondetti, E., Thomas, D. L., & Shmueli, K. (2016). Application of Laplacian-based Methods to Multi-echo Phase Data for Accurate Susceptibility Mapping. Proceedings of the 24th International Society for Magnetic Resonance in Medicine. Demetriou, E., Tachrount, M., Rega, M., Torrealdea, F., Shmueli, K., Farrow, M., & Golay, X. (2016). CEST Nuclear Overhauser Enhancement Imaging of Protein Misfolding in Mice at Different Stages of Prion Disease. Proceedings of the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Goodburn, R., Powell, N., O'Callaghan, J., Walker-Samuel, S., & Shmueli, K. (2016). Characterising and Modelling Susceptibility Artifacts in the Mouse Brain at 9.4 T. Proceedings of the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. O'Callaghan, J., Holmes, H., Powell, N., Wells, J., Ismail, O., Harrison, I., . . . Lythgoe, M. (2016). Does Tau Pathology Play a Role in Abnormal Iron Deposition in Alzheimer’s Disease? a Quantitative Susceptibility Mapping Study in the RTg4510 Mouse Model of Tauopathy. Proceedings of the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Dixon, E., Barnes, A., & Shmueli, K. (2016). Evaluation of an Iterative Phase Replacement Method for Susceptibility Mapping in Regions with No MRI Signal. Proceedings of the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Demetriou, E., Tachrount, M., Shmueli, K., Farrow, M., & Golay, X. (2016). High-Quality MRS Detects Metabolic Changes in Mice at Different Stages of Prion Disease. Proceedings of the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Shmueli, K., Dodd, S. J., van Gelderen, P., & Duyn, J. H. (2016). Investigating lipids as a source of chemical exchange-induced MRI frequency shifts. NMR in Biomedicine. doi:10.1002/nbm.3525 Mangia, S., Burton, P., Svatkova, A., Nestrasil, I., Sierra Lopez, A., Shmueli, K., . . . Michaeli, S. (2016). MRI Signatures in the Brain of Patients with PD and IRBD. Proceedings of the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Chary, K., Nissi, M., Rey, R., Manninen, E., Shmueli, K., Sierra, A., & Grohn, O. (2016). Quantitative Susceptibility Mapping of the Rat Brain After Traumatic Brain Injury. Proceedings of the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Finnerty, E., Ramasawmy, R., O'Callaghan, J., Lythgoe, M., Shmueli, K., Thomas, D., & Walker-Samuel, S. (2016). Quantitative Susceptibility Mapping to Interrogate Colorectal Metastases in Mouse Liver During Normoxia and Hyperoxia. Proceedings of the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Karsa, A., Biondetti, E., Punwani, S., & Shmueli, K. (2016). The Effect of Large Slice Thickness and Spacing and Low Coverage on the Accuracy of Susceptibility Mapping. Proceedings of the 24th Annual Meeting of the International Society for Magnetic Resonance in Medicine. O'Callaghan, J., Holmes, H., Powell, N., Ismail, O., Colgan, N., Wells, J., . . . Shmueli, K. (2015). Gadolinium-Enhanced Magnetic Susceptibility Contrast Is Reduced in the Corpus Callosum of a Mouse Model of Tauopathy. Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine. Mangia, S., Burton, P., Nestrasil, I., Nissi, M., Sierra, A., Shmueli, K., . . . Michaeli, S. (2015). Maximizing Tissue Contrast for MRI Evaluation of Parkinson’s Disease. Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine. Fairney, J., Liu, G., Shmueli, K., & Golay, X. (2015). SAS: Symmetric Analysis of Z-Spectra, a Method to Evaluate B0 Correction Techniques for CEST Data in Clinical Systems Using Non-Exchanging Phantoms. Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine. Shmueli, K., Kawadler, J., Carmichael, D., Clark, C. A., & Kirkham, F. J. (2015). Susceptibility Mapping in Sickle Cell Anaemia Patients with and Without Chronic Blood Transfusions. Proceedings of the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine. O'Callaghan, J., Wells, J., Shmueli, K., & Lythgoe, M. (2014). In Vivo Quantitative Susceptibility Mapping of the Mouse Brain at 9.4T: A New Contrast Mechanism to Investigate Genetic Models of Neurodegeneration. Proceedings of the Joint Annual Meeting ISMRM-ESMRMB. Johnson, A., Latifoltojar, A., Hamy, V., Fitzke, H., Shmueli, K., & Punwani, S. (2013). Assessing the contribution of hypoxia to R2* differences between cancerous and normal prostate tissue. ECR 2013 Book of Abstracts - B - Scientific Sessions. Insights into Imaging. doi:10.1007/s13244-013-0228-x Johnson, A., Latifoltojar, A., Hamy, V., Fitzke, Punwani, S., & Shmueli, K. (2013). Characterising the Contribution of Hypoxia to R2* Differences Between Prostate Tumours and Normal Tissue. Proceedings of the 21st Annual Meeting of the International Society for Magnetic Resonance in Medicine. Shmueli, K., van Gelderen, P., & Duyn, J. (2012). A Method for Measuring the Contribution of Lipids to Exchange-Induced Frequency Contrast Without Reference Chemicals. Proceedings of the 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Yao, B., Li, T. -. Q., van Gelderen, P., Shmueli, K., de Zwart, J. A., & Duyn, J. H. (2012). Corrigendum to "Susceptibility contrast in high field MRI of human brain as a function of tissue iron content" [NeuroImage 44/4 (2009) 1259-1266] (DOI:10.1016/j.neuroimage.2008.10.029). NeuroImage. Lee, J., Shmueli, K., Kang, B. T., Yao, B., Fukunaga, M., van Gelderen, P., . . . Duyn, J. (2012). The Contribution of Myelin to Magnetic Susceptibility-Weighted Contrasts in High-Field MRI of the Brain. Proceedings of the 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Lee, J., Shmueli, K., Kang, B. T., Yao, B., Fukunaga, M., van Gelderen, P., . . . Duyn, J. H. (2012). The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain. Neuroimage, 59 (4), 3967-3975. doi:10.1016/j.neuroimage.2011.10.076 Shmueli, K., Dodd, S., Wunder, C., & Duyn, J. (2011). Could Lipids Contribute to the Exchange-Induced Resonance Frequency Contrast in Brain Tissue?. Proceedings of the 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine. O'Gorman, R. L., Shmueli, K., Ashkan, K., Samuel, M., Lythgoe, D. J., Shahidiani, A., . . . Jarosz, J. (2011). Optimal MRI methods for direct stereotactic targeting of the subthalamic nucleus and globus pallidus. Eur Radiol, 21 (1), 130-136. doi:10.1007/s00330-010-1885-5 Yao, B., Bagnato, F., Shmueli, K., & Duyn, J. (2011). Susceptibility Contrast in Deep Brain Gray Matter Areas in Multiple Sclerosis Studied with 7T MRI. Proceedings of the 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine.