Olivo, Sandro - University College London - Department of medical physics and biomedical engineering

个人简介

Alessandro (“Sandro”) Olivo obtained his MSc (1995, summa cum laude) and PhD (1999) from the University of Trieste in Italy, and started his PhD after a stint as clinical physicist. After his PhD he was employed for 5 years by the same university to develop the imaging beamline at the local synchrotron. He then applied for a Marie Curie Fellowship, through which he moved to UCL and started translating synchrotron techniques into laboratory environments. Overall, Sandro has worked in x-ray imaging for 20 years, and is considered a pioneer in the field of X-Ray Phase-Contrast Imaging, having co-designed the in vivo mammography system operational at the Trieste synchrotron and invented the “edge-illumination” and “coded-aperture” methods. He has been awarded >£10M in research funding, published 175 papers, and given 90 conference talks/seminars, >50 of which were invited. Articles on his work appeared in Nature, Scientific American, Physics Today, Physics World.

研究领域

Sandro Olivo’s current research is to a large extent based around the new method he invented to produce x-ray phase contrast images with conventional x-ray sources. X-ray phase contrast imaging (XPCI) is an extremely powerful x-ray imaging method, which utilizes refraction and interference (instead of conventional attenuation) to generate image contrast. As a consequence, it increases the visibility of all details in an image, and it allows the detection of features classically considered to be invisible to x-rays. XPCI can thus transform all applications of x-ray imaging in medicine, biology, material science, security, etc. The main roadblock was that XPCI was considered to be restricted to synchrotron facilities, due to the stringent requirements it imposes on the radiation source. Olivo's method overcomes this limitation, making real-world implementation of XPCI possible for the first time. Indeed, his research is becoming increasingly translational in nature, and he is currently looking into the commercialisation of his method in various areas (see “industrial collaborators” on the AXIm web page). At the same time, the technology is being developed further, and new “blue sky” approaches are being devised – typically at synchrotrons. Examples include: • proof-of-concept studies in new areas of application, both in medicine and elsewhere (material science, non destructive testing, biology, cultural heritage, etc); • quantitative phase and "dark-field" methods for precise material identification and characterization; • new, "phase-based" contrast agents; • new "ultra-sensitive" phase methods at synchrotrons worldwide; • strategies to reduce radiation dose delivery based on the use of elastic x-ray processes. As well as the core activities in x-ray imaging, other areas of investigation are development and characterization of radiation detectors, image processing and image analysis.

近期论文

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Chen, Y., Guan, H., Hagen, C. K., Olivo, A., & Anastasio, M. A. (2017). Single-shot edge illumination x-ray phase-contrast tomography enabled by joint image reconstruction. Optics Letters, 42 (3), 619-622. doi:10.1364/OL.42.000619 Astolfo, A., Endrizzi, M., Kallon, G., Millard, T., Vittoria, F. A., & Olivo, A. (2016). A first investigation of accuracy, precision and sensitivity of phase-based x-ray dark-field imaging. Journal of Physics D: Applied Physics, 49 (48), 485501-1-485501-7. doi:10.1088/0022-3727/49/48/485501 Diemoz, P. C., Bravin, A., Sztrókay-Gaul, A., Ruat, M., Grandl, S., Mayr, D., . . . Olivo, A. (2016). A method for high-energy, low-dose mammography using edge illumination x-ray phase-contrast imaging. Physics in Medicine and Biology, 61 (24), 8750-8761. doi:10.1088/1361-6560/61/24/8750 Diemoz, P. C., Vittoria, F. A., Hagen, C. K., Endrizzi, M., Coan, P., Bravin, A., . . . Olivo, A. (2016). A single-image retrieval method for edge illumination X-ray phase-contrast imaging: application and noise analysis. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (12), 1759-1764. Elsevier. doi:10.1016/j.ejmp.2016.07.093 Endrizzi, M., Astolfo, A., Vittoria, F. A., Millard, T. P., & Olivo, A. (2016). Asymmetric masks for laboratory-based X-ray phase-contrast imaging with edge illumination. Scientific Reports, 6, 25466-1-25466-7. doi:10.1038/srep25466 Endrizzi, M., Astolfo, Price, B., Haig, I., & Olivo, A. (2016). Asymmetric masks for large field-of-view and high-energy X-ray phase contrast imaging. Journal of Instrumentation. Institute of Physics. doi:10.1088/1748-0221/11/12/C12009 Basta, D., Endrizzi, M., Vittoria, F. A., Astolfo, A., & Olivo, A. (2016). Compact and cost effective lab-based edge-illumination X-ray phase contrast imaging with a structured focal spot. Applied Physics Letters, 108 (22), 224102-1-224102-5. doi:10.1063/1.4953459 Zamir, A., Hagen, C. K., Diemoz, P. C., Endrizzi, M., Vittoria, F. A., Urbani, L., . . . Olivo, A. (2016). Increased robustness and speed in low-dose phase-contrast tomography with laboratory sources. Proceedings of SPIE - The International Society for Optical Engineering, 9967, 996716-1-996716-10. International Society for Optical Engineering. doi:10.1117/12.2236626 Endrizzi, M., Diemoz, P. C., Hagen, C. K., Millard, T. P., Vittoria, F. A., Wagner, U. H., . . . Olivo, A. (2016). Laboratory-based edge-illumination phase-contrast imaging: Dark-field retrieval and high-resolution implementations. 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Conference Record, 7431019-1-7431019-4. US: IEEE. doi:10.1109/NSSMIC.2014.7431019 Endrizzi, M., Astolfo, A., Price, B., Haig, I., & Olivo, A. (2016). Large field-of-view asymmetric masks for high-energy x-ray phase imaging with standard x-ray tube. Proceedings of SPIE - The International Society for Optical Engineering, 9964, 99640A-1-99640A-6. USA: International Society for Optical Engineering. doi:10.1117/12.2240491 Hagen, C. K., Zamir, A., Diemoz, P. C., Endrizzi, M., Kennedy, F., Jager, R. H., & Olivo, A. (2016). Low-dose x-ray phase contrast tomography: Experimental setup, image reconstruction and applications in biomedicine. 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Conference Record, 7430971-1-7430971-5. US: IEEE. doi:10.1109/NSSMIC.2014.7430971 Vittoria, F. A. (2016). New approaches for coherent and incoherent implementation of x-ray phase contrast imaging (Doctoral dissertation). UCL (University College London). Hagen, C. K., Zamir, A., Diemoz, P. C., Endrizzi, M., Vittoria, F. A., Maghsoudlou, P., . . . Olivo, A. (2016). Opportunities for phase-based computed tomography in the laboratory. Proceedings of the 4th International Conference on Image Formation in X-Ray Computed Tomography. ct-meeting.org. Maghsoudlou, P., Georgiades, F., Smith, H., Milan, A., Shangaris, P., Urbani, L., . . . De Coppi, P. (2016). Optimization of Liver Decellularization Maintains Extracellular Matrix Micro-Architecture and Composition Predisposing to Effective Cell Seeding. PLOS ONE, 11 (5), e0155324. doi:10.1371/journal.pone.0155324 Diemoz, P. C., Endrizzi, M., Hagen, C. K., Vittoria, F. A., Millard, T. P., & Olivo, A. (2016). Optimization of sensitivity, dose and spatial resolution in edge illumination X-ray phase-contrast imaging. 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Conference Record, 7430970-1-7430970-4. US: IEEE. doi:10.1109/NSSMIC.2014.7430970 Hagen, C. K., Endrizzi, M., Diemoz, P. D., & Olivo, A. (2016). Reverse projection retrieval in edge illumination x-ray phase contrast computed tomography. Journal of Physics D: Applied Physics, 49 (25), 255501-1-255501-9. doi:10.1088/0022-3727/49/25/255501 Zamir, A., Endrizzi, M., Hagen, C. K., Vittoria, F. A., Urbani, L., De Coppi, P., & Olivo, A. (2016). Robust phase retrieval for high resolution edge illumination x-ray phase-contrast computed tomography in non-ideal environments. Scientific Reports, 6, 31197-1-31197-9. doi:10.1038/srep31197 Modregger, P., Cremona, T. P., Benarafa, C., Schittny, J. C., Olivo, A., & Endrizzi, M. (2016). Small angle x-ray scattering with edge-illumination. Scientific Reports, 6, 30940-1-30940-8. doi:10.1038/srep30940 Hagen, C. K., Maghsoudlou, P., Totonelli, G., Diemoz, P. C., Endrizzi, M., Zamir, A., . . . Olivo, A. (2016). Strategies for fast and low-dose laboratory-based phase contrast tomography for microstructural scaffold analysis in tissue engineering. Proceedings of SPIE - The International Society for Optical Engineering, 9967, 996705-1-996705-7. USA: International Society for Optical Engineering. doi:10.1117/12.2237594 Diemoz, P. C., Vittoria, F. A., & Olivo, A. (2016). The concept of contrast transfer function for edge illumination X-ray phase-contrast imaging and its comparison with the free-space propagation technique. Optics Express, 24 (10), 11250-11265. doi:10.1364/OE.24.011250 Astolfo, A., Endrizzi, M., Price, B., Haig, I., & Olivo, A. (2016). The first large-area, high-X-ray energy phase contrast prototype for enhanced detection of threat objects in baggage screening. Proceedings of SPIE, 9995, 999504-1-999504-7. USA: International Society for Optical Engineering. doi:10.1117/12.2239556 Hagen, C. K., Coan, P., Bravin, A., Olivo, A., & Diemoz, P. C. (2015). A continuous sampling scheme for edge illumination x-ray phase contrast imaging. Journal of Applied Physics, 118 (5), 054901-1-054901-8. doi:10.1063/1.4927729 Kallon, GK, Wesolowski, M, Vittoria, FA, Endrizzi, M, Basta, D, Millard, TP, . . . Olivo, A. (2015). A laboratory based edge-Illumination x-ray phase-contrast imaging setup with two-directional sensitivity. Applied Physics Letters, 107 (20), 204105-1-204105-5. doi:10.1063/1.4935983 Endrizzi, M., Vittoria, F. A., Kallon, G., Basta, D., Diemoz, P. C., Vincenzi, A., . . . Olivo, A. (2015). Achromatic approach to phase-based multi-modal imaging with conventional X-ray sources. Optics Express, 23 (12), 16473-16480. doi:10.1364/OE.23.016473 Diemoz, P. C., Endrizzi, M., Hagen, C. K., Millard, T. P., Vittoria, F. A., & Olivo, A. (2015). Angular sensitivity and spatial resolution in edge illumination X-ray phase-contrast imaging. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 784, 538-541. ELSEVIER SCIENCE BV. doi:10.1016/j.nima.2014.12.027