个人简介

Giuseppe Battaglia is Professor of Molecular Bionics. His research is focused on the investigation of the specific design rules behind inter/intramolecular interactions and self-assembly of soft matter systems combining synthetic and supramolecular chemistry. In analogy to medical Bionics, where engineering and physical science converge to the design of replacement and/or enhancement of malfunctioning body parts, Prof Battaglia and his team apply molecular engineering and nanotechnology tools to copy and/or improve biological structures such as viruses for several applications including biotechnology, drug and gene delivery, diagnostic tools and cell engineering scaffolds. He has worked at UCL since 2013. Before this, he held positions as Lecturer -2006, Senior Lecturer -2009 and Professor -2011 in the Departments of Materials Sci. Eng. (2006-2009) and Biomedical Science (2009-2013) at the University of Sheffield. Prof Battaglia holds a Laurea in Chemical Engineering from University of Palermo (Italy) and a PhD in Physical Chemistry from the University of Sheffield.

研究领域

Physical Chemistry

Nanomedicine Drug delivery Physical Biology Active colloids Self assembly Vesicles, micelles and gels Biodegradable and biocompatible polymers Tissue engineering

近期论文

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Howorka, S., Messager, L., Burns, J. R., Kim, J., Cecchin, D., Hindley, J., . . . Battaglia, G. (2016). Biomimetic Hybrid Nanocontainers with Selective Permeability. Angewandte Chemie, 128 (37), 11272-11275. doi:10.1002/ange.201604677 Messager, L., Burns, J. R., Kim, J., Cecchin, D., Hindley, J., Pyne, A. L. B., . . . Howorka, S. (2016). Biomimetic Hybrid Nanocontainers with Selective Permeability. Angewandte Chemie International Edition, 55 (37), 11106-11109. doi:10.1002/anie.201604677 Simón-Gracia, L., Hunt, H., Scodeller, P., Gaitzsch, J., Kotamraju, V. R., Sugahara, K. N., . . . Teesalu, T. (2016). iRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomes. Biomaterials, 104, 247-257. doi:10.1016/j.biomaterials.2016.07.023 Ruiz-Pérez, L., Messager, L., Gaitzsch, J., Joseph, A., Sutto, L., Gervasio, F. L., & Battaglia, G. (2016). Molecular engineering of polymersome surface topology. Sci Adv, 2 (4), e1500948-?. doi:10.1126/sciadv.1500948 Simon-Gracia, L., Hunt, H., Scodeller, P. D., Gaitzsch, J., Braun, G. B., Willmore, A. -. M. A., . . . Teesalu, T. (2016). Paclitaxel-Loaded Polymersomes for Enhanced Intraperitoneal Chemotherapy. MOLECULAR CANCER THERAPEUTICS, 15 (4), 670-679. doi:10.1158/1535-7163.MCT-15-0713-T Tian, X., Nyberg, S., Sharp, P. S., Madsen, J., Daneshpour, N., Armes, S. P., . . . Battaglia, G. (2015). LRP-1-mediated intracellular antibody delivery to the Central Nervous System. SCIENTIFIC REPORTS, 5, ARTN 11990. doi:10.1038/srep11990 Robertson, J. D., Yealland, G., Avila-Olias, M., Chierico, L., Bandmann, O., Renshaw, S. A., & Battaglia, G. (2014). pH-sensitive tubular polymersomes: formation and applications in cellular delivery. ACS Nano, 8 (5), 4650-4661. doi:10.1021/nn5004088 Akinc, A., & Battaglia, G. (2013). Exploiting endocytosis for nanomedicines. Cold Spring Harbor Perspectives in Biology, 5 (11). doi:10.1101/cshperspect.a016980 Canton, I., Massignani, M., Patikarnmonthon, N., Chierico, L., Robertson, J., Renshaw, S. A., . . . Battaglia, G. (2013). Fully synthetic polymer vesicles for intracellular delivery of antibodies in live cells. FASEB J, 27 (1), 98-108. doi:10.1096/fj.12-212183 Madsen, J., Canton, I., Warren, N. J., Themistou, E., Blanazs, A., Ustbas, B., . . . Armes, S. P. (2013). Nile Blue-based nanosized pH sensors for simultaneous far-red and near-infrared live bioimaging. J Am Chem Soc, 135 (39), 14863-14870. doi:10.1021/ja407380t Viswanathan, P., Chirasatitsin, S., Ngamkham, K., Engler, A. J., & Battaglia, G. (2012). Cell instructive microporous scaffolds through interface engineering. J Am Chem Soc, 134 (49), 20103-20109. doi:10.1021/ja308523f Wang, L., Chierico, L., Little, D., Patikarnmonthon, N., Yang, Z., Azzouz, M., . . . Battaglia, G. (2012). Encapsulation of biomacromolecules within polymersomes by electroporation. Angewandte Chemie - International Edition, 51 (44), 11122-11125. doi:10.1002/anie.201204169 Canton, I., & Battaglia, G. (2012). Endocytosis at the nanoscale. Chem Soc Rev, 41 (7), 2718-2739. doi:10.1039/c2cs15309b Gaitzsch, J., Appelhans, D., Wang, L., Battaglia, G., & Voit, B. (2012). Synthetic bio-nanoreactor: Mechanical and chemical control of polymersome membrane permeability. Angewandte Chemie - International Edition, 51 (18), 4448-4451. doi:10.1002/anie.201108814 LoPresti, C., Massignani, M., Fernyhough, C., Blanazs, A., Ryan, A. J., Madsen, J., . . . Battaglia, G. (2011). Controlling polymersome surface topology at the nanoscale by membrane confined polymer/polymer phase separation. ACS Nano, 5 (3), 1775-1784. doi:10.1021/nn102455z Blanazs, A., Madsen, J., Battaglia, G., Ryan, A. J., & Armes, S. P. (2011). Mechanistic insights for block copolymer morphologies: how do worms form vesicles?. J Am Chem Soc, 133 (41), 16581-16587. doi:10.1021/ja206301a Massignani, M., Canton, I., Sun, T., Hearnden, V., Macneil, S., Blanazs, A., . . . Battaglia, G. (2010). Enhanced fluorescence imaging of live cells by effective cytosolic delivery of probes. PLoS One, 5 (5), e10459-?. doi:10.1371/journal.pone.0010459 Gill, M. R., Garcia-Lara, J., Foster, S. J., Smythe, C., Battaglia, G., & Thomas, J. A. (2009). A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells. Nat Chem, 1 (8), 662-667. doi:10.1038/nchem.406 Massignani, M., LoPresti, C., Blanazs, A., Madsen, J., Armes, S. P., Lewis, A. L., & Battaglia, G. (2009). Controlling cellular uptake by surface chemistry, size, and surface topology at the nanoscale. Small, 5 (21), 2424-2432. doi:10.1002/smll.200900578 Smart, T. P., Mykhaylyk, O. O., Ryan, A. J., & Battaglia, G. (2009). Polymersomes hydrophilic brush scaling relations. Soft Matter, 5 (19), 3607-3610. doi:10.1039/b908731a Howse, J. R., Jones, R. A., Battaglia, G., Ducker, R. E., Leggett, G. J., & Ryan, A. J. (2009). Templated formation of giant polymer vesicles with controlled size distributions. Nat Mater, 8 (6), 507-511. doi:10.1038/nmat2446 Lomas, H., Canton, I., MacNeil, S., Du, J., Armes, S. P., Ryan, A. J., . . . Battaglia, G. (2007). Biomimetic pH sensitive polymersomes for efficient DNA encapsulation and delivery. Advanced Materials, 19 (23), 4238-4243. doi:10.1002/adma.200700941 Battaglia, G., & Ryan, A. J. (2006). Neuron-like tubular membranes made of diblock copolymer amphiphiles. Angew Chem Int Ed Engl, 45 (13), 2052-2056. doi:10.1002/anie.200503334 Battaglia, G., & Ryan, A. J. (2005). Bilayers and interdigitation in block copolymer vesicles. J Am Chem Soc, 127 (24), 8757-8764. doi:10.1021/ja050742y Battaglia, G., & Ryan, A. J. (2005). The evolution of vesicles from bulk lamellar gels. Nat Mater, 4 (11), 869-876.