个人简介

Dr James Baker is a Senior Lecturer in Chemical Biology at University College London, UK. His research group is highly interdisciplinary, with interests in the development of innovative methodologies in bioconjugation, chemical biology and organic synthesis, and application of these to the design of new targeted therapeutics and diagnostics. He is also a co-founder of the spin-out company ThioLogics (www.thiologics.com), which offers site-specific conjugation methods for the assembly of next generation Biologics. Dr Baker was an RCUK fellow at UCL from 2007-2012, a lecturer 2012-2014, and a Senior Lecturer 2014 until present.

研究领域

Organic Chemistry and Chemical Biology

Organic Synthesis and Chemical Biology Bioconjugation Targeted Therapeutics Antibody conjugates as Therapeutics and Diagnostics Organic Photochemistry

近期论文

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Robinson, E., Nunes, J. P. M., Vassileva, V., Maruani, A., Nogueira, J. C. F., Smith, M. E. B., . . . Chudasama, V. (2017). Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody. RSC Advances, 7 (15), 9073-9077. doi:10.1039/C7RA00788D Pye, H., Butt, A., Reinert, H., Maruani, A., Nunes, J., Marklew, J. S., . . . Lovat, L. (2016). A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy. PHOTOCHEMICAL AND PHOTOBIOLOGICAL SCIENCES. doi:10.1039/c6pp00139d Huckvale, R., Mortensen, M., Pryde, D., Smart, T. G., & Baker, J. R. (2016). Azogabazine; a photochromic antagonist of the GABA(A) receptor. ORGANIC & BIOMOLECULAR CHEMISTRY, 14 (28), 6676-6678. doi:10.1039/c6ob01101b Lee, M. T. W., Maruani, A., Baker, J. R., Caddick, S., & Chudasama, V. (2016). Next-generation disulfide stapling: reduction and functional re-bridging all in one. CHEMICAL SCIENCE, 7 (1), 799-802. doi:10.1039/c5sc02666k Huckvale, R. (2016). Photoactive antagonists for the GABAA receptor (Doctoral dissertation). UCL. Fletcher, S. A., Sin, P. K. B., Nobles, M., Arstad, E., Tinker, A., & Baker, J. R. (2015). A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging. ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (37), 9559-9563. doi:10.1039/c5ob01468a Smith, M. E. B., Caspersen, M. B., Robinson, E., Morais, M., Maruani, A., Nunes, J. P. M., . . . Chudasama, V. (2015). A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine. ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (29), 7946-7949. doi:10.1039/c5ob01205h Nunes, J. P. M., Morais, M., Vassileva, V., Robinson, E., Rajkumar, V. S., Smith, M. E. B., . . . Chudasama, V. (2015). Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC). CHEMICAL COMMUNICATIONS, 51 (53), 10624-10627. doi:10.1039/c5cc03557k Richards, D. A., Fletcher, S. A., Nobles, M., Kossen, H., Tedaldi, L., Chudasama, V., . . . Baker, J. R. (2015). Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines. ORGANIC & BIOMOLECULAR CHEMISTRY, 14 (2), 455-459. doi:10.1039/c5ob02120k Marculescu, C., Kossen, H., Morgan, R. E., Mayer, P., Fletcher, S. A., Tolner, B., . . . Baker, J. R. (2014). Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds. Chem Commun (Camb), 50 (54), 7139-7142. doi:10.1039/c4cc02107j Youziel, J., Akhbar, A. R., Aziz, Q., Smith, M. E., Caddick, S., Tinker, A., & Baker, J. R. (2014). Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. Org Biomol Chem, 12 (4), 557-560. doi:10.1039/c3ob42141d Hull, E. A., Livanos, M., Miranda, E., Smith, M. E., Chester, K. A., & Baker, J. R. (2014). Homogeneous bispecifics by disulfide bridging. Bioconjug Chem, 25 (8), 1395-1401. doi:10.1021/bc5002467 Schumacher, F. F., Nunes, J. P., Maruani, A., Chudasama, V., Smith, M. E., Chester, K. A., . . . Caddick, S. (2014). Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging. Org Biomol Chem, 12 (37), 7261-7269. doi:10.1039/c4ob01550a Mortensen, M., Iqbal, F., Pandurangan, A. P., Hannan, S., Huckvale, R., Topf, M., . . . Smart, T. G. (2014). Photo-antagonism of the GABAA receptor. Nat Commun, 5, 4454-?. doi:10.1038/ncomms5454 Castañeda, L., Wright, Z. V. F., Marculescu, C., Tran, T. M., Chudasama, V., Maruani, A., . . . Baker, J. R. (2013). A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones. Tetrahedron Letters. Castañeda, L., Maruani, A., Schumacher, F. F., Miranda, E., Chudasama, V., Chester, K. A., . . . Caddick, S. (2013). Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation. Chem Commun (Camb), 49 (74), 8187-8189. doi:10.1039/c3cc45220d Baker, J. R., Schumacher, F. F., Caddick, S., Smith, M. E. B., Chudasama, V., & Maruani, A. (2013). Chemical modification of antibodies. WO/2013/132268. Roupany, A. J. A., & Baker, J. R. (2013). Diverse products accessible via [2+2] photocycloadditions of 3-aminocyclopentenones. RSC ADVANCES, 3 (27), 10650-10653. doi:10.1039/c3ra42106f Schumacher, F. F., Sanchania, V. A., Tolner, B., Wright, Z. V., Ryan, C. P., Smith, M. E., . . . Baker, J. R. (2013). Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'. Sci Rep, 3, 1525-?. doi:10.1038/srep01525 Nathani, R. I., Chudasama, V., Ryan, C. P., Moody, P. R., Morgan, R. E., Fitzmaurice, R. J., . . . Caddick, S. (2013). Reversible protein affinity-labelling using bromomaleimide-based reagents. Org Biomol Chem, 11 (15), 2408-2411. doi:10.1039/c3ob40239h Moody, P., Smith, M. E., Ryan, C. P., Chudasama, V., Baker, J. R., Molloy, J., & Caddick, S. (2012). Bromomaleimide-linked bioconjugates are cleavable in mammalian cells. Chembiochem, 13 (1), 39-41. doi:10.1002/cbic.201100603 Jones, M. W., Strickland, R. A., Schumacher, F. F., Caddick, S., Baker, J. R., Gibson, M. I., & Haddleton, D. M. (2012). Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides. Chemical Communications, 48 (34), 4064-4066. doi:10.1039/c2cc30259d Jones, M. W., Strickland, R. A., Schumacher, F. F., Caddick, S., Baker, J. R., Gibson, M. I., & Haddleton, D. M. (2012). Polymeric dibromomaleimides as extremely efficient disulfide bridging bioconjugation and pegylation agents. Journal of the American Chemical Society, 134 (3), 1847-1852. doi:10.1021/ja210335f Tedaldi, L. M., Aliev, A. E., & Baker, J. R. (2012). [2+2] photocycloadditions of thiomaleimides. Chem Commun (Camb), 48 (39), 4725-4727. doi:10.1039/c2cc31673k Chudasama, V., Smith, M. E., Schumacher, F. F., Papaioannou, D., Waksman, G., Baker, J. R., & Caddick, S. (2011). Bromopyridazinedione-mediated protein and peptide bioconjugation. Chem Commun (Camb), 47 (31), 8781-8783. doi:10.1039/c1cc12807h