个人简介

Erik Årstad is Professor of Radiochemistry. He leads a multidisciplinary research group bridging medicinal chemistry, radiochemistry and nuclear imaging. The group currently consists of 5 postdocs, 4 PhD students and 2 Master students. The focus of his work is to advance biomedical research by developing labelling chemistry and novel tracers for non-invasive diagnostic imaging with Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET). The group is part of the Institute of Nuclear Medicine, UCL/UCLH (https://www.ucl.ac.uk/nuclear-medicine), and collaborates closely with the Centre for Advanced Biomedical Imaging (CABI; http://www.ucl.ac.uk/cabi). Prof Årstad has worked at UCL since 2008 (2008-2015: Senior Lecturer; 2015 Professor). Before this, he was a research associate at Imperial College, working with Professor A.G.M. Barrett (2001-2002), he then took up a postdoctoral position at UCL, working with Professor P.J. Ell (2003-2004) and later worked for GE Healthcare, Hammersmith Imanet, as Chemistry Research Team Leader (2004-2006) and Tracer Research Team Leader (2006-2008).

研究领域

Organic Chemistry and Chemical Biology

Radiolabelling (radioiodine and fluorine-18) Tracer development Medicinal chemistry Nuclear Imaging (PET, SPECT, autoradiography)

近期论文

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Weitsman, G., Mitchell, N. J., Evans, R., Cheung, A., Kalber, T. L., Bofinger, R., . . . Ng, T. (2017). Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor. Oncogene. doi:10.1038/onc.2016.522 Sander, K., Lashley, T., Gami, P., Gendron, T., Lythgoe, M. F., Rohrer, J., . . . Arstad, E. (2016). Characterisation of tau PET tracer [18F]AV-1451 binding to post-mortem tissue in Alzheimer's disease, primary tauopathies and other dementias. Alzheimer's & Dementia. doi:10.1016/j.jalz.2016.01.003 Fletcher, S. A., Sin, P. K. B., Nobles, M., Arstad, E., Tinker, A., & Baker, J. R. (2015). A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging. ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (37), 9559-9563. doi:10.1039/c5ob01468a Patel, N., Duffy, B. A., Badar, A., Lythgoe, M. F., & Arstad, E. (2015). Bimodal Imaging of Inflammation with SPECT/CT and MRI Using Iodine-125 Labeled VCAM-1 Targeting Microparticle Conjugates. BIOCONJUGATE CHEMISTRY, 26 (8), 1542-1549. doi:10.1021/acs.bioconjchem.5b00380 Yan, R., Carroll, L., Glaser, M., Rajkumar, V., Diocou, S., Sander, K., . . . Arstad, E. (2015). Development of a radioiodinated isatin as a potential SPECT tracer for imaging apoptosis. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 58, S71. Sander, K., Galante, E., Gendron, T., Yiannaki, E., Patel, N., Kalber, T. L., . . . Arstad, E. (2015). Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography. JOURNAL OF MEDICINAL CHEMISTRY, 58 (15), 6058-6080. doi:10.1021/acs.jmedchem.5b00652 Gendron, T., Sander, K., Cybulska, K., Gray, V., & Arstad, E. (2015). Dibenzothiophene sulfonium salts as leaving groups for aromatic [18F]fluorination - exemplified by highly efficient direct labeling of the mGluR5 PET tracer [18F]FPEB. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 58, S8. Wells, L. A., Kealey, S., Howes, O., Henriksen, G., Passchier, J., & Arstad, E. (2015). Evaluation of [11C]EA10 to image GluN2B-containing NMDA receptor subunits. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42, S477. SPRINGER. Badar, A., Kiru, L., Kalber, T. L., Jathoul, A., Straathof, K., Arstad, E., . . . Pule, M. (2015). Fluorescence-guided development of a tricistronic vector encoding bimodal optical and nuclear genetic reporters for in vivo cellular imaging. EJNMMI RESEARCH, 5, UNSP 18. doi:10.1186/s13550-015-0097-z Sander, K., Gendron, T., Yiannaki, E., Cybulska, K., Kalber, T. L., Lythgoe, M., & Arstad, E. (2015). Functionalized Triarylsulfonium Salts for Aromatic [F-18]Fluorination of Drug-like Small Molecules. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 58, S4. Della Peruta, M., Badar, A., Rosales, C., Chokshi, S., Kia, A., Nathwani, D., . . . Nathwani, A. C. (2015). Preferential Targeting of Disseminated Liver Tumors Using a Recombinant Adeno-Associated Viral Vector. HUMAN GENE THERAPY, 26 (2), 94-103. doi:10.1089/hum.2014.052 Vassileva, V., Rajkumar, V., Mazzantini, M., Robson, M., Badar, A., Sharma, S., . . . Pedley, R. B. (2015). Significant Therapeutic Efficacy with Combined Radioimmunotherapy and Cetuximab in Preclinical Models of Colorectal Cancer. JOURNAL OF NUCLEAR MEDICINE, 56 (8), 1239-1245. doi:10.2967/jnumed.115.157362 Della Peruta, M., Badar, A., Rosales, C., Chokshi, S., Kia, A., Nathwani, D., . . . Nathwani, A. (2014). Development and in vivo evaluation of a liver-specific, tumour-selective recombinant adeno-associated vector to target hepatocellular carcinoma. HUMAN GENE THERAPY, 25 (5), A4. MARY ANN LIEBERT, INC. Galante, E., Okamura, T., Sander, K., Kikuchi, T., Okada, M., Zhang, M. R., . . . Årstad, E. (2014). Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET. J Med Chem, 57 (3), 1023-1032. doi:10.1021/jm401764a Kiru, L., Badar, A., Jathoul, A., Kalber, T. L., Galante, E., Arstad, E., . . . Pule, M. (2014). Establishing a Novel Strategy To Monitor Gene Expression in the Brain Using the Human Sodium Iodide Symporter Reporter Gene and Radioiodinated Iodopurine Probe. MOLECULAR THERAPY, 22, S173-S174. NATURE PUBLISHING GROUP. Kiru, L., Badar, A., Jathoul, A., Kalber, T. L., Galante, E., Arstad, E., . . . Pule, M. (2014). In Vivo Characterisation of the Human Sodium Iodide Symporter and the Human Norepinephrine Transporter Reporter Genes Using SPECT Imaging. MOLECULAR THERAPY, 22, S279-S280. NATURE PUBLISHING GROUP. Wright, Z. V. F., Tabor, A. B., Hall, A., Arstad, E., & Koltzenburg, M. (2014). Probing pain receptors with cysteine knot peptides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248. AMER CHEMICAL SOC. Yan, R., Sander, K., Galante, E., Rajkumar, V., Badar, A., Robson, M., . . . Årstad, E. (2013). A one-pot three-component radiochemical reaction for rapid assembly of 125I-labeled molecular probes. J Am Chem Soc, 135 (2), 703-709. doi:10.1021/ja307926g Yan, R., Sander, K., Galante, E., Rajkumar, V., Badar, A., Robson, M., . . . Arstad, E. (2013). A one-pot three-component radiochemical reaction for rapid assembly of I-125-labelled molecular probes. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 56 (2), 62-63. Galante, E., Schoultz, B. W., Koepp, M., & Arstad, E. (2013). Chelator-accelerated one-pot 'click' labeling of small molecule tracers with 2-[¹⁸F]fluoroethyl azide. Molecules, 18 (5), 5335-5347. doi:10.3390/molecules18055335 Sander, K., Galante, E., Yiannaki, E., Patel, N., Bauer, F., Robson, M., . . . Arstad, E. (2013). Development of a Pro drug Tracer for Functional Imaging of Multiple Drug Resistance. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 40, S114. O'Shea, D., Ahmad, R., Arstad, E., Avory, M., Chau, W. F., Durrant, C., . . . Trigg, W. (2013). Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands - Potential novel positron emitting tomography imaging agents. Bioorganic and Medicinal Chemistry Letters, 23 (8), 2368-2372. doi:10.1016/j.bmcl.2013.02.057 Nguyen, Q., Challapalli, A., Smith, G., Fortt, R., Glaser, M., Arstad, E., . . . Aboagye, E. O. (2013). Imaging apoptosis with positron emission tomography: bench-to-bedside development of the caspase-3/7-specific radiotracer [F-18] ICMT-11. JOURNAL OF NUCLEAR MEDICINE, 54, 19. Walker-Samuel, S., Ramasawmy, R., Torrealdea, F., Rega, M., Johnson, S. P., Rajkumar, V., . . . Golay, X. (2013). In vivo imaging of glucose uptake and metabolism in tumors. Nature Medicine. doi:10.1038/nm.3252 Arstad, E., Galante, E., Sander, K., & Koepp, M. (2013). Labelling strategies for development of F-18 PET tracers. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 56 (2), 51-52.