个人简介

Jim Anderson is a Professor of Organic Chemistry and work in his laboratory covers a broad portfolio of projects that combine contemporary synthetic organic chemistry methodology with highly adventurous, blue sky research. The basic theme in all of these projects is inventing fundamentally different ways of creating new organic structures in a stereocontrolled and, if applicable, catalytic fashion. This encompasses the development of new reaction methodology which is showcased in the synthesis of biologically active natural and non-natural products. He has worked at UCL since 2009. Before that he was at the department of Chemistry at the University of Nottingham for 10 years (2003-9: Professor of Chemistry; 1999-2002: Reader and EPSRC advanced fellow in organic chemistry) and began his academic career at the department of Chemistry at the University of Sheffield (1998-9 Senior Lecturer and EPSRC advanced fellow in organic chemistry; 1993-8: Lecturer)

研究领域

Organic Chemistry and Chemical Biology

Asymmetric synthesis Reaction methodology Target synthesis Nitro-Mannich reaction Alpha-functionalisation of ethers Synthesis of nrIR chemiluminescent and fluorescent probes Developing new reactions of CO2

近期论文

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Anderson, J. C., Grounds, H., Jathoul, A. P., Murray, J. A. H., Pacman, S. J., & Tisi, L. (2017). A Convergent Synthesis and Optical Properties of Near-infrared Emitting Bioluminescent Infra-luciferins. RSC Advances. doi:10.1039/c6ra19541e Anderson, J. C., Campbell, I. B., Campos, S., Reid, I. H., Rundell, C. D., Shannon, J., & Tizzard, G. J. (2016). Reductive conjugate addition nitro-Mannich route for the stereoselective synthesis of 1,2,3,4-tetrahydroquinoxalines. Organic & biomolecular chemistry, 14 (35), 8270-8277. doi:10.1039/C6OB01530A Anderson, J. C., Barham, J. P., & Rundell, C. D. (2015). Asymmetric Intramolecular Conjugate Addition Nitro-Mannich Route to cis-2-Aryl-3-nitrotetrahydroquinolines. ORGANIC LETTERS, 17 (16), 4090-4093. doi:10.1021/acs.orglett.5b02036 Anderson, J. C., Campbell, I. B., Campos, S., Shannon, J., & Tocher, D. A. (2015). Stereoselective synthesis of 1,2-diamine containing indolines by a conjugate addition nitro-Mannich reaction. Org Biomol Chem, 13 (1), 170-177. doi:10.1039/c4ob01793e Anderson, J. C., & Rundell, C. D. (2015). Stereoselective Synthesis of Densely Substituted Tetrahydroquinolines by a Conjugate Addition nitro-Mannich Reaction with Carbon Nucleophiles. Synlett: accounts and rapid communications in synthetic organic chemistry. Jathoul, A. P., Grounds, H., Anderson, J., & Pule, M. A. (2014). A Dual Color Far-Red to Near-Infrared Firefly Luciferin Analogue Designed for Multi-Parametric Bioluminescence Imaging. Angewandte Chemie. Anderson, J. C., Kalogirou, A. S., & Tizzard, G. J. (2014). Conjugate addition nitro-Mannich reaction of carbon and heteroatom nucleophiles to nitroalkenes. Tetrahedron. doi:10.1016/j.tet.2014.10.042 Anderson, J. C., Campbell, I. B., Campos, S., & Shannon, J. (2014). Diastereoselective synthesis of beta-aminosulfones from the 1,2-addition to N-(para-methoxyphenyl) imines. TETRAHEDRON LETTERS, 55 (52), 7206-7208. doi:10.1016/j.tetlet.2014.11.017 Anderson, J. C., Grounds, H., Reeves, S., & Taylor, P. W. (2014). Improved synthesis of structural analogues of (-)-epicatechin gallate for modulation of staphylococcal β-lactam resistance. Tetrahedron. doi:10.1016/j.tet.2014.03.052 Palacios, L., Rosado, H., Micol, V., Rosato, A. E., Bernal, P., Arroyo, R., . . . Taylor, P. W. (2014). Staphylococcal phenotypes induced by naturally occurring and synthetic membrane-interactive polyphenolic β-lactam resistance modifiers. PLoS One, 9 (4), e93830-?. doi:10.1371/journal.pone.0093830 Anderson, J. C., & Koovits, P. J. (2013). An enantioselective tandem reduction/nitro-Mannich reaction of nitroalkenes using a simple thiourea organocatalyst. CHEMICAL SCIENCE, 4 (7), 2897-2901. doi:10.1039/c3sc50613d Noble, A., & Anderson, J. C. (2013). Nitro-Mannich reaction. Chem Rev, 113 (5), 2887-2939. doi:10.1021/cr300272t Anderson, J. C., Grounds, H., & Szalóki, G. (2013). Synthesis of planar chiral ferrocenyl cyclopentadienyl chelate ligand precursors. Tetrahedron: Asymmetry, 24 (17), 1023-1034. doi:10.1016/j.tetasy.2013.07.006 Anderson, J. C., Kalogirou, A. S., Porter, M. J., & Tizzard, G. J. (2013). Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining step. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 9. doi:10.3762/bjoc.9.200 Anderson, J. C., Noble, A., & Torres, P. R. (2012). An intramolecular nitro-Mannich route to functionalised tetrahydroquinolines. TETRAHEDRON LETTERS, 53 (42), 5707-5710. doi:10.1016/j.tetlet.2012.08.062 Anderson, J. C., Blake, A. J., Koovits, P. J., & Stepney, G. J. (2012). Diastereoselective reductive nitro-Mannich reactions. J Org Chem, 77 (10), 4711-4724. doi:10.1021/jo300535h Noble, A. (2012). Investigation into the use of 1,2-diamines in fused heterocycle synthesis (Doctoral dissertation). UCL (University College London). Anderson, J. C., Noble, A., & Tocher, D. A. (2012). Reductive nitro-Mannich route for the synthesis of 1,2-diamine containing indolines and tetrahydroquinolines. J Org Chem, 77 (16), 6703-6727. doi:10.1021/jo3010827 Anderson, J. C., Horsfall, L. R., Kalogirou, A. S., Mills, M. R., Stepney, G. J., & Tizzard, G. J. (2012). Stereoselective synthesis of densely functionalized pyrrolidin-2-ones by a conjugate addition/nitro-Mannich/lactamization reaction. J Org Chem, 77 (14), 6186-6198. doi:10.1021/jo301000r Anderson, J. C., & Moreno, R. B. (2012). Synthesis of ureas from titanium imido complexes using CO2 as a C-1 reagent at ambient temperature and pressure. Org Biomol Chem, 10 (7), 1334-1338. doi:10.1039/c1ob06576a Anderson, J. C., McCarthy, R. A., Paulin, S., & Taylor, P. W. (2011). Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (-)-epicatechin gallate. Bioorg Med Chem Lett, 21 (23), 6996-7000. doi:10.1016/j.bmcl.2011.09.116 Anderson, J. C., Stepney, G. J., Mills, M. R., Horsfall, L. R., Blake, A. J., & Lewis, W. (2011). Enantioselective conjugate addition nitro-Mannich reactions: solvent controlled synthesis of acyclic anti- and syn-β-nitroamines with three contiguous stereocenters. J Org Chem, 76 (7), 1961-1971. doi:10.1021/jo102408u Noble, A., & Anderson, J. C. (2011). Investigation into the use of 1,2-diamines in fused heterocycle synthesis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 242. Anderson, J. C., & Davies, E. A. (2010). Diastereoselective synthesis of substituted prolines via 5-endo-trig cyclisations of aza-[2,3]-Wittig sigmatropic rearrangement products. TETRAHEDRON, 66 (33), 6300-6308. doi:10.1016/j.tet.2010.04.095 Anderson, J. C., & Bou-Moreno, R. (2010). The efficient synthesis of carbodiimides using a titanium imido complex. TETRAHEDRON, 66 (47), 9182-9186. doi:10.1016/j.tet.2010.09.073