Ji, Haitao - University of South Florida

个人简介

B.S. Second Military Medical University, China Ph.D. Second Military Medical University, China Postdoctoral Fellow, Northwestern University, USA

研究领域

Our laboratory focuses on the rational design and synthesis of drug-like small molecules that can modulate specific cellular signaling pathways with an emphasis on protein–protein interactions and target specificity. Medicinal Chemistry, organic synthesis, and biological chemistry are of primary importance for our studies. We initiate our individual studies based on the molecular recognition between two proteins, develop new chemistry tools and techniques for the rational design, synthesis and characterization of selective protein–protein interaction inhibitors, and apply these newly established tools and techniques to tackle important and challenging therapeutic targets. Technique core in our laboratory is fragment-based de novo design. There are four training components in the Ji research lab: (1) Computer Modeling and Bioinformatic Analysis; (2) Organic Synthesis and Compound Characterizations; (3) Biochemical Studies; and (4) Cell-Based Studies.

近期论文

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Sang, Peng; Zhang, Min; Shi, Yan; Li, Chunpu; Abdulkadir, Sami; Li, Qi; Ji,* Haitao;* Cai, Jianfeng.* Inhibition of β-catenin/B-cell lymphoma 9 protein–protein interaction using α-helix-mimicking sulfono-γ-AApeptide inhibitors. Proc. Natl Acad. Sci. U.S.A., 2019, in press. Wang, Zhen; Zhang, Min; Wang, Jin; Ji, Haitao.* Optimization of peptidomimetics as selective inhibitors for the β-catenin/T-cell factor protein–protein interaction. J. Med. Chem. 2019, 62 (7), 3617–3635. Wu, Xiaowei; Ji, Haitao.* Ruthenium-catalyzed C-H allylation of alkenes with allyl alcohols via C-H bond activation in aqueous solution. J. Org. Chem. 2018, 83 (19), 12094–12102. Wu, Xiaowei; Ji, Haitao.* Rhodium(III)-catalyzed C-H allylation of indoles with allyl alcohols via β-hydroxide elimination. Org. Biomol. Chem. 2018, 16 (31), 5691-5698. Huang, Chenfei; Cao, Zhe, Ma, Jun; Shen, Yi; Bu, Yiwen; Khoshaba, Ramina; Shi, Guiyuan; Huang, Dan; Liao, Duan-Fang; Ji, Haitao; Jin, Junfei;* Cao, Deliang.* AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells. Mol. Carcinog. 2018, 57 (10), 1300–1310. Wu, Xiaowei; Ji, Haitao.* Rhodium-catalyzed [4 + 1] cyclization via C-H activation for the synthesis of divergent heterocycles bearing a quaternary carbon. J. Org. Chem. 2018, 83 (8), 4650–4656. Zhang, Min; Wang, Zhen; Zhang, Yongqiang; Guo, Wenxing; Ji, Haitao.* Structure-based optimization of small-molecule inhibitors for the β-catenin/B-cell lymphoma 9 protein–protein interaction. J. Med. Chem. 2018, 61 (7), 2989–3007. Wu, Xiaowei; Ji, Haitao.* Ruthenium(II)-catalyzed regio- and stereoselective C−H allylation of indoles with allyl alcohols. Org. Lett. 2018, 20 (8), 2224–2227. Teuscher, Kevin B.; Zhang, Min; Ji, Haitao.* A versatile method to determine the cellular bioavailability of small-molecule inhibitors. J. Med. Chem. 2017, 60 (1), 157–169. This paper is featured as ACS Editors' Choice and recommended by F1000 faculty! F1000 Prime Recommended Wisniewski, John A.; Yin, Jinya; Teuscher, Kevin B.; Zhang, Min; Ji, Haitao.* Structure-based design of 1,4-dibenzoylpiperazines as β-catenin/B-cell lymphoma 9 protein–protein interaction inhibitors. ACS Med. Chem. Lett. 2016, 7 (5), 508–513. Zhang, Yongqiang; Teuscher, Kevin B.; Ji, Haitao.* Direct α-heteroarylation of amides (α to nitrogen) and ethers through a benzaldehyde-mediated photoredox reaction. Chem. Sci. 2016, 7 (3), 2111–2118. Hoggard, Logan R.; Zhang, Yongqiang; Zhang, Min; Panic, Vanja; Wisniewski, John A.; Ji, Haitao.* Rational Design of selective small-molecule inhibitors for β-catenin/B-cell lymphoma 9 protein–protein interactions. J. Am. Chem. Soc. 2015, 137 (38), 12249–12260. Catrow, J. Leon; Zhang, Yongqiang; Zhang, Min; Ji, Haitao.* Discovery of selective small-molecule inhibitors for the β-catenin/T-cell factor protein–protein interaction through the optimization of the acyl hydrazone moiety. J. Med. Chem. 2015, 58 (11), 4678–4692. Zhang, Min; Wisniewski, John A.; Ji, Haitao.* AlphaScreen selectivity assay for β-catenin/B-cell lymphoma 9 inhibitors. Anal. Biochem. 2015, 469, 43–53. Drury, Paul P.; Davidson, Joanne O.; Mathai, Sam; van den Heuji, Lotte G.; Ji, Haitao; Bennet, Laura; Tan, Sidhartha; Silverman, Richard B.; Gunn, Alistair J.* nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep. Neuropharmacology 2014, 83C, 62–70. Huang, Zheng; Zhang, Min; Burton, Shawn D.; Katsakhyan, Levon N.; Ji, Haitao.* Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein–protein interactions. ACS Chem. Biol. 2014, 9 (1), 193–201. Zhang, Min; Catrow, J. Leon; Ji Haitao.* High-throughput selectivity assays for small-molecule inhibitors of β-catenin/T-cell factor protein-protein interactions. ACS Med. Chem. Lett. 2013, 4 (2), 306–311. Yu, Binxun; Huang, Zheng; Zhang, Min; Dillard, Darren R.; Ji, Haitao.* Rational design of small-molecule inhibitors for β-catenin/T-cell factor protein-protein interactions by bioisostere replacement. ACS Chem. Biol. 2013, 8 (3), 524–529. Recommended by the F1000 Faculty: F1000 Prime Recommended Zhang, Min; Huang, Zheng; Yu, Binxun; Ji, Haitao.* New homogeneous high-throughput assays for inhibitors of β-catenin/Tcf protein-protein interactions. Anal. Biochem. 2012, 424 (1), 57–63.