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个人简介

1994-1997 哥伦比亚大学 生物物理化学 博士 PhD 1988-1990 浙江大学 凝聚态物理 硕士 MS 1986-1988 浙江大学 物理 学士 BS 1984-1986 浙江大学 首届混合班 荣誉学位 周如鸿,AAAS Fellow, APS Fellow, 浙江大学求是讲席教授,生命科学院院长,上海高等研究院院长,科技部十四五“生物大分子与微生物”专家组成员,哥伦比亚大学化学系兼职教授。2000-2020年期间在 IBM Watson 研究院工作,历任研究员,杰出研究员,蛋白质科学实验室主任,软物质科学系系主任,IBM蓝色基因计划生命科学首席科学家等;同时,2002年起在哥伦比亚大学化学系担任兼职助理教授,兼职教授,开设《生物物理化学》,《高等统计力学》等课程; 2020年全职回到母校工作,并参与筹建浙江大学定量生物中心与浙江大学上海高等研究院。长期从事计算生物学、生物物理、生物化学与人工智能+等交叉学科的研究,在蛋白质设计、纳米药物设计、肿瘤免疫机制等领域取得了一系列国际领先的原创性成果。授权30余项国际专利,在国际权威学术刊物发表论文300余篇 (其中 2篇 Nature,2篇 Science,1篇 Cell,20篇 Nature子刊,16篇 PNAS, 14篇 JACS),文章总引用超过26000余次,H因子83 (Google Scholar)。曾获全美化学学会计算化学奖 (DEC Award),IBM杰出科技贡献奖 (IBM技术类最高奖),IBM杰出创新奖, 并于2009年以IBM蓝色基因计划主要成员之一荣获奥巴马总统颁发的美国国家技术奖章 (总统奖)。周如鸿教授于2011年当选美国科学促进会会士 (AAAS Fellow),美国物理学会会士(APS Fellow),并于2012年入选IBM全球八大研究院“将对IBM,对世界,可能产生最重大影响的五名科学家之一”。周如鸿教授同时担任美国分子科学领域顶尖的Telluride科学研究中心董事会的董事(Board of Directors),和美国芝加哥大学多尺度科学中心的科学顾问(Scientific Advisory Board)。

研究领域

计算生物学 生物物理学 人工智能+

近期论文

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Chongrong Shen#, Shenghai Chang#, Qinghua Luo#, Kevin C. Chan#, Zhibo Zhang, Bingnan Luo, Teng Xie, Guangwen Lu, Xiaofeng Zhu, Xiawei Wei, Changjiang Dong, Ruhong Zhou*, Xing Zhang*, Xiaodi Tang*, Haohao Dong*, Structural basis of BAM mediated outer membrane b-barrel protein assembly and release, Nature, 617, 185-193, 2023 Yi Song, David R. Bell, Rizwan Ahmed, Kevin C. Chan, Sangyun Lee, Abdel Rahim A. Hamad*, and Ruhong Zhou*, A mutagenesis study of autoantigen optimization for potential T1D vaccine design, Proc. Natl. Acad. Sci., 120 (16) e2214430120, 2023, DOI: 10.1073/pnas.2214430120 Dong Zhang#, Lulu Qiao#, Xiaobo Lei#, Xiaojing Dong, Yunguang Tong, Jianwei Wang*, Zhiye Wang*, and Ruhong Zhou*, Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein, Nature Commun., 14, in press, 2023, DOI : 10.1038/s41467-023-39410-8 Xiaolong Li*, Nishant Kumar Singh, David R. Collins, Robert Ng, Angela Zhang, Pedro A. Lamothe-Molina, Peter Shahinian, Shutong Xu, Kemin Tan, Alicja Piechocka-Trocha, Jonathan M. Urbach, Jeffrey K. Weber, Gaurav D. Gaiha, Overbeck Christian Takou Mbah, Tien Huynh, Sophia Cheever, James Chen, Michael Birnbaum, Ruhong Zhou, Bruce D. Walker*, and Jia-huai Wang*, Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide, Nature Commun., 14, 2929, 2023 Jianqiang Mu#, Chenyang Xue#, Lei Fu#, Zongjun Yu, Minhan Nie, Mengqi Wu, Xinmeng Chen, Kun Liu, Ruiqian Bu, Ying Huang, Baisheng Yang, Jianming Han, Qianru Jiang, Kevin C. Chan, Ruhong Zhou, Huilin Li, Ancheng Huang, Yong Wang* and Zhongmin Liu*, Conformational cycle of human polyamine transporter ATP13A2, Nature Commun., 2023, 14, 1978 , 2023, DOI: 10.1038/s41467-023-37741-0 Qianqian Zhuang#, Fengfeng Guo#, Lei Fu#, Yufei Dong, Shaofang Xie, Xue Ding, Shuangyi Hu, Xuanhao D. Zhou, Yangwei Jiang, Hui Zhou, Yue Qiu, Zhaoying Lei, Mengyao Li, Huajian Cai, Mingjie Fan, Lingjie Sang, Yong Fu, Dong Zhang, Aifu Lin, Xu Li, Tilo Kunath, Ruhong Zhou*, Ping Liang*, Zhong Liu*, Qingfeng Yan*, 1-Deoxynojirimycin promotes cardiac function and rescues mitochondrial cristae in mitochondrial hypertrophic cardiomyopathy, J Clin. Invest. 2023 https://doi.org/10.1172/JCI164660 Bin Ji, Jianxiang Huang, Kexuan Zou, Meijun Liu, Yufeng Pei, Jing Huang, Yong Wang, Jinglin Wang, Ruhong Zhou*, Wenwen Xin*, Jie Song*, Direct Visualization of the Dynamic Process of Epsilon Toxin on Hemolysis, Small Methods, 7, 2300028, 2023 Linlin Tang#, Mengjiao Huang#, Mingjiao Zhang#, Yufeng Pei, Yan Liu, Yong Wei, Chaoyong Yang, Teng Xie, Dong Zhang, Ruhong Zhou*, Yanling Song*, Jie Song*, De Novo Evolution of an Antibody‐Mimicking Multivalent Aptamer via a DNA Framework, Small Methods, 7, 2300327, 2023 Juan Du*, Yichen Wang, Wenfan Chen, Mingling Xu, Ruhong Zhou, Huixia Shou, Jun Chen*, High-resolution anatomical and spatial transcriptome analyses reveal two types of meristematic cell pools within the secondary vascular tissue of poplar stem, Molecular Plant, in press, 2023, DOI: 10.1016/j.molp.2023.03.005 Jianxiang Huang, Damiano Buratto, Ruhong Zhou*, Probing the electrostatic aggregation of nanoparticles with oppositely charged molecular ions, Aggregate, 4, e324, 2023, DOI: 10.1002/agt2.324 Guangqiang Yin, Wei Lu*, Jianxiang Huang, Rui Li, Depeng Liu, Longqiang Li, Ruhong Zhou, Guifei Huo*, Tao Chen*, Ultralong excimer phosphorescence by the self-assembly and confinement of terpyridine derivatives in polymeric matrices, Aggregate, 4, e344, 2023, DOI: 10.1002/agt2.344 Panli Han, Lianxue Zhang, Yaqi Fu, Youyu Fu, Jianxiang Huang, Jinlin He, Peihong Ni, Taimoor Khan, Yang Jiao, Zaixing Yang, Ruhong Zhou*, A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ via enhancement of tumor hypoxia levels, Nanoscale, 2023, 15, 237-247, DOI: 10.1039/D2NR04021B Jianxiang Huang, Yuexin Su, Damiano Buratto, Wei Song, Zhuxian Zhou, Youqing Shen, Ruhong Zhou*, Influence of Core Topologies on Poly-l-lysine Dendrimer Structures, J. Phys. Chem. B, in press, 2023, DOI: 10.1021/acs.jpcb.2c08983 Guangqiang Yin, Jianxiang Huang, Depeng Liu, Rui Li, Shuxin Wei, Muqing Si, Feng Ni, Yinfei Zheng*, Qiu Yang, Ruhong Zhou*, Xiaoxia Le*, Wei Lu, Tao Chen*, Mechanochemical transformation of fluorescent hydrogel based on dynamic lanthanide-terpyridine coordination, Chinese Chemical Letters, Volume 34, Issue 3, 2023, DOI: 10.1016/j.cclet.2022.03.013 Jianxiang Huang, Kevin C Chan, Ruhong Zhou*, Novel Inhibitory Role of Fenofibric Acid by Targeting Cryptic Site on the RBD of SARS-CoV-2, Biomolecules, 2023, 13(2), 359, DOI: 10.3390/biom13020359 Mei Feng, Yi Song, Ruhong Zhou*, Calculation of Relative Binding Free Energy for Mutations in Protein Complexes: The Alchemical Path, Editor, Yong Wang, Ruhong Zhou, A Practical Guide to Recent Advances in Multiscale Modeling and Simulation of Biomolecules, AIP Publishing LLC, 2023 Yong Wang, Ruhong Zhou, A Practical Guide to Recent Advances in Multiscale Modeling and Simulation of Biomolecules, AIP Publishing LLC, DOI: https://doi.org/10.1063/9780735425279, ISBN electronic: 978-0-7354-2527-9, ISBN print: 978-0-7354-2524-8, 2023 Qiang Zhu#, Hong Zhou#, Liming Wu, Jie Zhang, Yong Wang, Didi Geng, Zhiya Fan, Weijie Qin, Ruhong Zhou*, and Wen Yi*, O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1, Nature Chem. Biol., 18, 1087-1095, 2022, DOI:10.1038/s41589-022-01085-5 Chengyu Shi#, Ying Wang#, Minjie Wu#, Yu Chen, Fangzhou Liu, Zheyuan Shen, Yiran Wang, Shaofang Xie, Yingying Shen, Lingjie Sang, Zhen Zhang, Zerui Gao, Luojia Yang, Lei Qu, Zuozhen Yang, Xinyu He, Yu Guo, Chenghao Pan, Jinxin Che, Huaiqiang Ju, Jian Liu, Zhijian Cai, Qingfeng Yan, Luyang Yu, Liangjing Wang, Xiaowu Dong, Pinglong Xu, Jianzhong Shao, Yang Liu, Xu Li*, Wenqi Wang*, Ruhong Zhou*, Tianhua Zhou* and Aifu Lin*, Promoting anti-tumor immunity by targeting TMUB1, a modulator 2 of PD-L1 polyubiquitination and glycosylation, Nature Commun. 13, 6951, 2022 Xiaolong Li*, Nishant Kumar Singh, Robert Ng, David R. Collins, Angela Zhang, Pedro A. Lamothe-Molina, Peter Shahinian, Shutong Xu, Kemin Tan, Alicja Piechocka-Trocha, Jonathan M. Urbach, Jeffrey K. Weber, Gaurav Gaiha, Overbeck Christian Takou Mbah, Tien Huynh, Sophia Cheever, James Chen, Michael Birnbaum, Ruhong Zhou, Bruce D. Walker*, and Jia-huai Wang*, Molecular basis of differential HLA class I-restricted T cell 2 recognition of a highly networked viral peptide, Nature Commun. 13, 3rd revision, 2022 Meng Jiang#, Binqiang Wang#, Rui Ye#, Ning Yu, Zhenming Xie, Yuejin Hua, Ruhong Zhou*, Bing Tian,*, Shang Dai,* Evidence and impacts of nanoplastic accumulation in crop grains, Advanced Science, 9, 2202336, 2022 Shang Dai#, Rui Ye#, Jianxiang Huang, Binqiang Wang, Zhenming Xie, Xinwen Ou, Ning Yu, Cheng Huang, Yuejin Hua*, Ruhong Zhou*, Bing Tian*, Distinct lipid membrane interaction and uptake of differentially charged nanoplastics in bacteria, J. Nanobio. 20, 1-15, 2022 Zonglin Gu#, Zhi He#, Fanfan Chen#, Lijun Meng, Jiandong Feng, Ruhong Zhou*, Ionic Liquid Decelerates Single-Stranded DNA Transport through Molybdenum Disulfide Nanopores, ACS Appl. Mater. Interf. 14, 32618-32624, 2022 Meiyun Xu#, Shitong Zhang#, Tao Wang, Bin Yu, Zaixing Yang, Xiaolin Wang*, Ruhong Zhou*, Daoben Hua*, De Novo Design of a Pt Nanocatalyst on a Conjugated Microporous Polymer-Coated Honeycomb Carrier for Oxidation of Hydrogen Isotopes, ACS Appl. Mater. Interf. 14, 7826-7835, 2022 Meiyun Xu, Lei Zhou, Linjuan Zhang, Shitong Zhang, Fulong Chen, Ruhong Zhou, Daoben Hua*, Two-Dimensional Imprinting Strategy to Create Specific Nanotrap for Selective Uranium Adsorption with Ultrahigh Capacity, ACS Appl. Mater. Interf. 14, 9408-9417, 2022 Leili Zhang, Hongsuk Kang, Jose M. Perez-Aguilar, Ruhong Zhou*, Possible Co-Evolution of Polyglutamine and Polyproline in Huntingtin Protein: Proline-Rich Domain as Transient Folding Chaperone, J. Phys. Chem. Lett, 13, 6331-6341, 2022, DOI: 10.1021/acs.jpclett.2c01184 Jianxiang Huang#, Wei Song#, Lijun Meng#, Youqing Shen, Ruhong Zhou*, Role of polyplex charge density in lipopolyplex, Nanoscale, 14, 7174-7180, 2022 Lijun Meng#, Jianxiang Huang#, Zhi He, Ruhong Zhou*, Single nucleobase identification for transversally-confined ssDNA using longitudinal ionic currents, Nanoscale, 14, 6922-6929, 2022 Panli Han, Lianxue Zhang*, Yaqi Fu, Youyu Fu, Jianxiang Huang, Jinlin He, Peihong Ni, Taimoor Khan, Yang Jiao, Zaixing Yang and Ruhong Zhou*, A Dual-response Drug Delivery System with X-ray and ROS to Boost the Anti-Tumor Efficiency of TPZ via Enhancement of Tumor Hypoxia Level, Nanoscale, 14, in press, 2022 Quan Zhou#, Jianxiang Huang#, Lingqiao Hao, Yu Geng, Changhuo Xu, Zhuxian Zhou, Jianbin Tang, Ruhong Zhou*, Youqing Shen*, Hydrophobicity Effects of γ-Glutamyl Transpeptidase-Responsive Polymers on the Catalytic Activity and Transcytosis Efficacy, Bioconjugate Chem., 33, 2132-2142, 2022, DOI: 10.1021/acs.bioconjchem.2c00391 Guotao Yuan#, Shitong Zhang#, Zaixing Yang, Shunjie Wu, Huanjun Chen, Xin Tian, Si Cheng, Yue Pan*, Ruhong Zhou*, Precisely modulated 2D PdCu alloy nanodendrites as highly active peroxidase mimics for the elimination of biofilms, Biomater. Sci., in press, 2022 Danni Li#, Jianxiang Huang#, Yichong Lao, Yiling Zhang, Wei Song, Jie Song, Cong Liu, Bin Dai*, Ruhong Zhou*, Potassium Ion Mediated Double-Layered Upright Assembly of Negatively Charged Amyloid-like Peptides at Mica/Water Interface, Adv. Mater. Interf., 9, 2200402, 2022, DOI: 10.1002/admi.202200402 Dan Qiao, Yuang Chen, Haojing Tan, Ruhong Zhou & Jiandong Feng*, De novo design of transmembrane nanopores, Sci. China Chem. 65, in press, 2022, DOI: 10.1007/s11426-022-1354-5 Kevin C Chan, Yi Song, Zheng Xu, Chun Shang, Ruhong Zhou*, SARS-CoV-2 Delta Variant: Interplay between Individual Mutations and Their Allosteric Synergy, Biomolecules, 12, 1742, 2022 Yi Song, Sangyun Lee, David Bell, Benjamin Goudey, Ruhong Zhou*, Binding Affinity Calculations of Gluten Peptides to HLA Risk Modifiers: DQ2. 5 versus DQ7. 5, J. Phys. Chem. B, 126, 5151-5160, 2022 Qing Guo#, Ying Yang#, Lin Zhao, Jian Chen, Guangxin Duan*, Zaixing Yang*, Ruhong Zhou, Graphene oxide toxicity in W1118 flies, Sci. Tot. Environ. 805, 150302, 2022 Guangqiang Yin, Jianxiang Huang, Depeng Liu, Rui Li, Shuxin Wei, Muqing Si, Feng Ni, Yinfei Zheng, Qiu Yang, Ruhong Zhou*, Xiaoxia Le*, Wei Lu, Tao Chen*, Mechanochemical transformation of fluorescent hydrogel based on dynamic lanthanide-terpyridine coordination, Chin. Chem. Lett. DOI:10.1016/j.cclet.2022.03.013, 2022 Guotao Yuan#, Shitong Zhang#, Zaixing Yang, Xin Tian, Si Cheng, Yue Pan*, Ruhong Zhou*, 2D PdCu Alloy Nanodendrites Manifest Effective Peroxidase-Like Activity Against Biofilms, Research Square DOI:10.21203/rs.3.rs-1162314/v1, 2022 Giacomo Domeniconi, Leili Zhang, Guojing Cong, Chih-Chieh Yang, Ruhong Zhou, Optical Flow Based Forecasting of Binding States in Molecular Dynamic Simulations, US Patent Pub. 17,154,120, July 21, 2022 Giacomo Domeniconi, Leili Zhang, Guojing Cong, Chih-Chieh Yang, Ruhong Zhou, Altering protein-ligand structure according to protein-ligand binding affinity, US Patent Pub. 17,065,548, April 14, 2022 Zhen Zhang, Nasha Qiu, Shuling Wu, Xin Liu, Zhuxian Zhou, Jianbin Tang, Yanpeng Liu, Ruhong Zhou, Youqing Shen*,Dose-Independent Transfection of Hydrophobized Polyplexes, Adv. Mater. 33, 2102219, 2021 DOI: 10.1002/adma.202102219 Linwei He#, Long Chen#, Xinglong Dong#, Shitong Zhang#, Mingxing Zhang, Xing Dai, Xiajie Liu, Peng Lin, Kunfeng Li, Cailing Chen, Tingting Pan, Fuyin Ma, Junchang Chen, Mengjia Yuan, Yugang Zhang, Lei Chen, Ruhong Zhou, Yu Han*, Zhifang Chai, Shuao Wang*,A nitrogen-rich covalent organic framework for simultaneous dynamic capture of iodine and methyl iodide, Chem, 7, 699-714, 2021 Fanfan Chen#; Zonglin Gu#; Chunxiao Zhao; Yuang Chen; Xiaowei Jiang; Zhi He; Yuxian Lu; Ruhong Zhou; Jiandong Feng*, Ionic conductance oscillations in sub-nanometer pores probed by optoelectronic control, Matter, 4,2378-2391, 2021 Zhi He, Ruhong Zhou*, Exploring an In-Plane Graphene and Hexagonal Boron Nitride Array for Separation of Single Nucleotides, ACS Nano, 15, 11704 - 11710, 2021 DOI: 10.1021/acsnano.1c02450 Guang-Qiang Yin, Sneha Kandapal, Chung-Hao Liu, Heng Wang, Jianxiang Huang, Shu-Ting Jiang, Tan Ji, Yu Yan, Sandra Khalife, Ruhong Zhou, Libin Ye, Bingqian Xu, Hai-Bo Yang, Mu-Ping Nieh, Xiaopeng Li*, Metallo-Helicoid with Double Rims: Polymerization Followed by Folding by Intramolecular Coordination, Angew. Chem. 60, 1281-1289, 2021 DOI: 10.1002/anie.202010696 Mei Feng#, Yi Song#, Serena H Chen, Yuanzhao Zhang, Ruhong Zhou*, Molecular Mechanism of Secreted Amyloid-β Precursor Protein in Binding and Modulating GABABR1a, Chem. Sci., 12,6107-6116, 2021,DOI: 10.1039/D0SC06946A Zonglin Gu#, Austin M. Baggetta#, Yu Chong, Leigh D. Plant*, Xuan-Yu Meng*, Ruhong Zhou*,Multifaceted Regulation of Potassium Ion Channels by Graphene Quantum Dots, ACS Appl. Mater. Interf. 13, 27784-27795, 2021 Rui Ye, Wei Song, Mei Feng, Ruhong Zhou*, Potential interference of graphene nanosheet to immune response via disrupting the recognition of TCR to HLA-presented KK10: A molecular dynamics simulation study, Nanoscale, 13, 19255-19263, 2021 Xinyu Zhang#, Shitong Zhang#, Zaixing Yang, Zhuanhua Wang*, Xin Tian*, Ruhong Zhou*, Self-cascade MoS 2 nanozymes for efficient intracellular antioxidation and hepatic fibrosis therapy, Nanoscale, 13, 12613-12622, 2021 Dan Zhu, Jiang Li, Lian-Hui Wang, Qian Li, Lihua Wang, Bo Song, Ruhong Zhou*, Chunhai Fan*, Hydrophobic Collapse-Driven Nanoparticle Coating with Poly-Adenine Adhesives, Chem. Commun., 57, 3801-3804, 2021, DOI: 10.1039/D1CC00628B Xuchang Su, Zhi He, Lijun Meng, Hong Liang, Ruhong Zhou*, Planar Boronic Graphene and Nitrogenized Graphene Heterostructure for Protein Stretch and Confinement, Biomolecules, 11, 1756, 2021 Mei Feng, Sangyun Lee, Chun Chan, Ruhong Zhou*, Molecular Insight into AC Electric Field Enhanced Removal of Protein Aggregates from a Material Surface, J. Phys. Chem. B, 125, 12147-12153, 2021 Dong Zhang, Shi-Jie Chen*, Ruhong Zhou*, Modeling Noncanonical RNA Base Pairs by a Coarse-Grained IsRNA2 Model, J. Phys. Chem. B, 125, 11907-11915, 2021 Xiaotong Lei, Shengtang Liu, Ruhong Zhou, Xuan-Yu Meng*, Molecular Dynamics Simulation Study on Interactions of Cycloviolacin with Different Phospholipids, J. Phys. Chem. B, 125, 3476-3485,2021 Xuejie Xie#, Zhenyu Hou#, Guangxin Duan#, Shitong Zhang, Hong Zhou, Zaixing Yang*, Ruhong Zhou*, Boron nitride nanosheets elicit significant hemolytic activity via destruction of red blood cell membranes,Colloids and Surfaces B: Biointerfaces, 203, 111765, 2021 Huizhen Zheng, Zonglin Gu, Yanxia Pan, Jie Chen, Qianqian Xie, Shujuan Xu, Meng Gao, Xiaoming Cai, Shengtang Liu, Weili Wang, Wei Li, Xi Liu, Zaixing Yang*, Ruhong Zhou, Ruibin Li*, Biotransformation of rare earth oxide nanoparticles eliciting microbiota imbalance,Particle and fibre toxicology, 18, 1-14, 2021 Tingjie Zhan, Leili Zhang, Shixuan Cui, Weiping Liu, Ruhong Zhou, Shulin Zhuang*, Dioxybenzone triggers enhanced estrogenic effect via metabolic activation: in silico, in vitro and in vivo investigation,Environmental Pollution, 268, 115766, 2021 Leili Zhang#,*, Giacomo Domeniconi#,*, Chih-Chieh Yang, Seung-gu Kang, Ruhong Zhou, Guojing Cong, CASTELO: Clustered Atom Subtypes aidEd Lead Optimization--a combined machine learning and molecular modeling method,BMC Bioinformatics, 22, 338, 2021 Pu Chun Ke, Ruhong Zhou, Louise C Serpell, Roland Riek, Tuomas PJ Knowles, Hilal A Lashuel, Ehud Gazit, Ian W Hamley, Thomas P Davis, Marcus Fändrich, Daniel Erik Otzen, Matthew R Chapman, Christopher M Dobson, David S Eisenberg, Raffaele Mezzenga*, Half a century of amyloids: past, present and future, Chem. Soc. Rev. 49, 5473-5509, 2020, DOI: 10.1039/C9CS00199A Xiaochuan Ma#, Sangyun Lee#, Xingshu Fei, Ge Fang, Tien Huynh, Chunying Chen, Zhifang Chai, Cuicui Ge*, Ruhong Zhou*,Proteasome activity regulated by charged gold nanoclusters: Implications for neurodegenerative diseases, Nano Today, 35, 100933, 2020 Nannan Shen#, Zaixing Yang#, Shengtang Liu#, Xing Dai, Chengliang Xiao, Kathryn Taylor-Pashow, Dien Li, Chuang Yang, Jie Li, Yugang Zhang, Mingxing Zhang, Ruhong Zhou*, Zhifang Chai, Shuao Wang*,99TcO4−removal from legacy defense nuclear waste by an alkaline-stable 2D cationic metal organic framework, Nature Communications, 11, 5571, 2020 David R Bell, Jeffrey K Weber, Wang Yin, Tien Huynh, Wei Duan*, Ruhong Zhou*, In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers, Proc. Natl. Acad. Sci., 117, 8486–8493, 2020 Mingxing Zhang#, Junchang Chen#, Shitong Zhang#, Xiaoqi Zhou, Linwei He, Matthew V Sheridan, Mengjia Yuan, Maojiang Zhang, Long Chen, Xing Dai, Fuyin Ma, Jingdong Wang, Jiangtao Hu, Guozhong Wu, Xueqian Kong, Ruhong Zhou, Thomas E Albrecht-Schmitt, Zhifang Chai, Shuao Wang*, Electron Beam Irradiation as a General Approach for the Rapid Synthesis of Covalent Organic Frameworks under Ambient Conditions, J. Am. Chem. Soc., 142, 9169-9174,2020, DOI:10.1021/jacs.0c03941 Hanzhou Liu#, Haoming Qin#, Nannan Shen, Siqi Yan, Yaxing Wang, Xuemiao Yin, Xinjian Chen, Chao Zhang, Xing Dai*, Ruhong Zhou, Xiaoping Ouyang, Zhifang Chai, Shuao Wang*, Emergence of Radical Stabilizing Metal‐Organic Framework as a New Type of Radio‐Photoluminescence Dosimeter, Angew. Chem.59, 15209-15214, 2020 Dongyang Xu#, Long Chen#, Xing Dai#, Baoyu Li, Yaxing Wang, Wei Liu, Jie Li, Yi Tao, Yanlong Wang, Yong Liu*, Guowen Peng*, Ruhong Zhou, Zhifang Chai, Shuao Wang*,A Porous Aromatic Framework Functionalized with Luminescent Iridium(III) Organometallic Complexes for Turn-On Sensing of 99TcO4–, ACS Appl. Mater. Interf. 12, 15288-15297, 2020 Lianxue Zhang#, Shitong Zhang#, Jiaying Xu#, Youyun Li, Jinlin He, Ying Yang, Tien Huynh, Peihong Ni, Guangxin Duan, Zaixing Yang*, Ruhong Zhou*, Low-Dose X-ray-Responsive Diselenide Nanocarriers for Effective Delivery of Anticancer Agents, ACS Appl. Mater. Interf. 12, 43398-43407, 2020 Catherine A Bessell#,Ariel Isser#, Jonathan J Havel#, Sangyun Lee, David R Bell, John W Hickey, Worarat Chaisawangwong, Joan Glick Bieler, Raghvendra Srivastava, Fengshen Kuo, Tanaya Purohit, Ruhong Zhou*, Timothy A Chan*, Jonathan P Schneck*, Commensal bacteria stimulate antitumor responses via T cell cross-reactivity, JCI Insight, 5, e135597, 2020 Ruhong Zhou*, Thomas Weikl*, Yu-qiang Ma*,Theoretical modeling of interactions at the bio-nano interface, Nanoscale, 12, 10426-10429, 2020 Wei Zhang*, Yezhe Chen, Tien Huynh, Yunqiu Yang, Xianqing Yang, Ruhong Zhou*,Directional Extraction and Penetration of Phosphorene Nanosheets to Cell Membranes, Nanoscale, 12, 13822-13828, 2020 Zhi He, Ruhong Zhou*,Planar Graphene/h-BN/Graphene Heterostructure for Protein Stretch and Confinement, Nanoscale, 12, 2810-2819, 2020 Serena H Chen, Jose Manuel Perez-Aguilar, Ruhong Zhou*,Graphene-extracted membrane lipids facilitate the activation of integrin αvβ8, Nanoscale, 12, 7939-7949, 2020 Baoyu Li, Xuejie Xie, Guangxin Duan, Serena H Chen, Xuan-Yu Meng, Ruhong Zhou*,Binding Patterns and Dynamics of Double-stranded DNA on Phosphorene Surface, Nanoscale, 12, 9430-9439, 2020 Maja C Ziegler, Annika Nelde, Jeffrey K Weber, Christian M Schreitmüller, Glòria Martrus, Tien Huynh, Madeleine J Bunders, Sebastian Lunemann, Stefan Stevanovic, Ruhong Zhou*, Marcus Altfeld*, HIV-1 induced changes in HLA-C∗03: 04-presented peptide repertoires lead to reduced engagement of inhibitory natural killer cell receptors, AIDS, 34, 1713-1723, 2020 Yin Zhong#, Rui Sun#, Yu Geng, Quan Zhou, Ying Piao, Tao Xie, Ruhong Zhou, Youqing Shen*, N-Oxide polymer–cupric ion nanogels potentiate disulfiram for cancer therapy, Biomater. Sci. 8, 1726-1733, 2020 Xuanchu Ge, Xing Dai, Hong Zhou, Zaixing Yang, Ruhong Zhou*,Stabilization of Open-Shell Single Bonds within Endohedral Metallofullerene, Inorg. Chem. 59, 3606-3618, 2020 Baoyu Li, Yuanzhao Zhang, Xuanyu Meng*, Ruhong Zhou*,Zipper-like Unfolding of dsDNA Caused by Graphene Wrinkles, J. Phys. Chem. C 124, 3332-3340, 2020 Leili Zhang, Ruhong Zhou*, Structural basis of potential binding mechanism of remdesivir to SARS-CoV-2 RNA dependent RNA polymerase, J. Phys. Chem. B 124, 6955-6962, 2020 Aodong Zou, Peng Xiu, Xinwen Ou, Ruhong Zhou*,Spontaneous Translocation of Single-Stranded DNA in Graphene–MoS2Heterostructure Nanopores: Shape Effect, J. Phys. Chem. B 124, 9490-9496, 2020 Zonglin Gu, Jose Manuel Perez-Aguilar, Lijun Meng, Ruhong Zhou*, Partial Denaturation of Villin Headpiece upon Binding to a Carbon Nitride Polyaniline (C3N) Nanosheet, J. Phys. Chem. B 124, 7557-7563, 2020 Aodong Zou, Sangyun Lee, Jingyuan Li, Ruhong Zhou*, Retained Stability of the RNA Structure in DNA Packaging Motor with a Single Mg2+Ion Bound at the Double Mg-Clamp Structure, J. Phys. Chem. B 124, 701-707, 2020 Wei Song, Zhifeng Jing, Lijun Meng, Ruhong Zhou*, Tungsten Oxide Nanodots Exhibit Mild Interactions with WW and SH3 Modular Protein Domains, ACS Omega, 5, 11005-11012, 2020 Rizwan Ahmed, Zahra Omidian, Adebola Giwa, Benjamin Cornwell, Neha Majety, David R. Bell, Sangyun Lee, Hao Zhang, Aaron Michels, Stephen Desiderio, Scheherazade Sadegh-Nasseri, Hamid Rabb, Mario Suva, Simon Gritsch, Patrick Cahan, Ruhong Zhou*, Chunfa Jie, Thomas Donner and Abdel R. Hamad*, A public BCR present in a unique dual-receptor-expressing lymphocyte from type 1 diabetes patients encodes a potent T cell autoantigen, Cell, 177, 1583–1599, 2019 Binquan Luan*, Ruhong Zhou, Spontaneous ssDNA stretching on graphene and hexagonal boron nitride in plane heterostructures, Nature Commun. 10, 4610, 2019 Xiaomei Wang, Xing Dai, Cen Shi, Jianmei Wan, Mark A. Silver, Linjuan Zhang, Lanhua Chen, Xuan Yi, Bizheng Chen, Duo Zhang, Kai Yang, Juan Diwu*, Jianqiang Wang, Yujie Xu, Ruhong Zhou*, Zhifang Chai, Shuao Wang*, A 3, 2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo, Nature Commun. 10, 2570, 2019 Binquan Luan, Guangxue Xu, Mei Feng, Le Cong*,Ruhong Zhou*, Combined Computational–Experimental Approach to Explore the Molecular Mechanism of SaCas9 with a Broadened DNA Targeting Range, J. Am. Chem. Soc. 141, 6545-6552, 2019 Daopeng Sheng#, Lin Zhu#, Xing Dai#, Chao Xu, Peng Li, Carolyn Pearce, Chengliang Xiao*, Jing Chen, Ruhong Zhou, Tao Duan, Omar K Farha, Zhifang Chai, Shuao Wang*, Successful Decontamination of 99TcO4- in Groundwater at Legacy Nuclear Sites by a Cationic Metal Organic Framework with Hydrophobic Pockets, Angew. Chem. Intl. Ed., 58, 4968-4972, 2019, DOI 10.1002/anie.201814640, 2019 Binquan Luan*, Ruhong Zhou, Atomic-scale Fluidic Diodes Based on Triangular Nanopores in Bilayer Hexagonal Boron Nitride, Nano Lett., 19, 977–982, 2019 Liming Wang#, Peiyu Quan#, Serena H Chen#, Wei Bu, Yu-Feng Li, Xiaochun Wu, Junguang Wu, Leili Zhang, Yuliang Zhao, Xiaoming Jiang, Binhua Lin*, Ruhong Zhou*, Chunying Chen*, Stability of Ligands on Nanoparticles Regulating the Integrity of Biological Membranes at the Nano–Lipid Interface, ACS Nano, 13, 8680-8693, 2019 Linwei He#, Shengtang Liu#, Long Chen#, Xing Dai, Jie Li, Mingxing Zhang, Fuyin Ma, Chao Zhang, Zaixing Yang*, Ruhong Zhou, Zhifang Chai, Shuao Wang*, Mechanism unravelling for ultrafast and selective 99TcO4−uptake by a radiation-resistant cationic covalent organic framework: a combined radiological experiment and molecular dynamics simulation study, Chem. Sci., 10, 4293-4305, 2019, DOI: 10.1039/C9SC00172G Aleksandr Kakinen*, Yunxiang Sun, Ibrahim Javeda, Ava Faridi, Emily H. Pilkington, Pouya Faridi, Anthony W. Purcell, Ruhong Zhou, Feng Ding, Sijie Lin, Pu Chun Ke*, Thomas P. Davis*, Physical and toxicological profiles of human IAPP amyloids and plaques, Science Bulletin, 64, 26-35, 2019 Zonglin Gu#, Lin Zhao#, Cuicui Ge#, Shengtang Liu, Ge Fang, Serena S Chen, Zaixing Yang*, Ruhong Zhou*, Facet-regulated adhesion of double-stranded DNA on palladium surfaces, Nanoscale, 11, 1827-1836, 2019 Zonglin Gu#, Wei Song#, Serena H Chen, Baoyu Li, Weifeng Li, Ruhong Zhou*, Defect-assisted protein HP35 denaturation on graphene, Nanoscale, 10, 2019, 10.1039/C9NR01143A Zonglin Gu#, Serena H Chen#, Zhaowen Ding, Wei Song, Wei Wei, Shengtang Liu, Guanghui Ma*, Ruhong Zhou*, Molecular Mechanism of Robust Macrophage Immune Responses Induced by PEGylated Molybdenum Disulfide, Nanoscale, 2019, 10.1039/C9NR04358F Shengtang Liu#, Xiuhua Yin#, Hong Zhou, Bo Zhou, Qiwen Shao, Zaixing Yang*, Ruhong Zhou*, Different Platinum Crystal Surfaces Show Very Distinct Protein Denaturation Capability, Nanoscale, 10, 2019, 10.1039/C9NR03682B Haiying Cui#, Zonglin Gu#, Xiaochen Chen#, Lin Lin, Zegao Wang, Xing Dai, Zaixing Yang, Lei Liu, Ruhong Zhou*, Mingdong Dong*, Stimulating antibacterial activities of graphitic carbon nitride nanosheets with plasma treatment, Nanoscale, 11, 18416-18425, 2019 Baoyu Li, David R Bell, Zonglin Gu, Weifeng Li*, Ruhong Zhou*, Protein WW domain denaturation on defected graphene reveals the significance of nanomaterial defects in nanotoxicity, Carbon, 146, 257-264, 2019 Jose Manue Perez-Aguilar, Seung-gu Kang, Leili Zhang, Ruhong Zhou*, Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer, ACS Chem. Neurosci. 10, 2019, 10.1021/acschemneuro.9b00438 Hong Zhou#, Zaixing Yang#, Xin Tian#, Lei Chen, Sangyun Lee, Tien Huynh, Cuicui Ge, Ruhong Zhou*, Lanosterol disrupts the aggregation of amyloid-β peptides, ACS Chem. Neurosci. 10, 4051-4060, 2019 Guangxin Duan, Lu Chen, Zhifeng Jing, Phil De Luna, Ling Wen, Leili Zhang, Lin Zhao, Jiaying Xu, Zhen Li, Zaixing Yang, Ruhong Zhou*, Robust Antibacterial Activity of Tungsten Oxide (WO3-x) Nanodots, Chem. Res. Toxico. 32, 1357-1366, 2019 Mei Feng, David R Bell, Hongsuk Kang, Qiwen Shao, Ruhong Zhou*, Exploration of HIV-1 fusion peptide–antibody VRC34. 01 binding reveals fundamental neutralization sites, Phys. Chem. Chem Phys., 21, 18569-18576, 2019 Hong Zhou, Shengtang Liu, Xiuhua Yin, Zengpeng Li, Zaixing Yang*, Ruhong Zhou*, Molecular Origin of the Stability Difference in Four Shark IgNAR Constant Domains, Biophys. J. 116, 1907-1917, 2019 Zhi He, Jingyuan Li, Serena H Chen, Ruhong Zhou*, Surface Inhomogeneity of Graphene Oxide Influences Dissociation of Aβ16-21Peptide Assembly, J. Phys. Chem. B. 123, 2019, 10.1021/acs.jpcb.9b07359 Leili Zhang, Binquan Luan, Ruhong Zhou*, Parameterization of Molybdenum Disulfide Interacting with Water Using the Free Energy Perturbation Method, J. Phys. Chem. B. 123, 7243-7252, 2019 Leili Zhang, David R Bell, Binquan Luan, Ruhong Zhou*, Exploring the binding mechanism between human profilin (PFN1) and polyproline-10 through binding mode screening, J. Chem. Phys. 150, 015102, 2019 Xiuhua Yin, Shengtang Liu, Jose Manuel Perez-Aguilar, Hong Zhou, Qiwen Shao, Zaixing Yang*, Ruhong Zhou*, Different protonated states at the C-terminal of the amyloid-bpeptide modulate the stability of S-shaped protofibril, J. Chem. Phys. 150, 185102, 2019 Diego Chowell#, Luc GT Morris#, Claud M Grigg#, Jeffrey K Weber, Robert M Samstein, Vladimir Makarov, Fengshen Kuo, Sviatoslav M Kendall, David Requena, Nadeem Riaz, Benjamin Greenbaum, James Carroll, Edward Garon, David M Hyman, Ahmet Zehir, David Solit, Michael Berger, Ruhong Zhou, Naiyer A Rizvi*, Timothy A Chan*, Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy, Science, 359, 582-587, 2018 Ge Fang#, Weifeng Li#, Xiaomei Shen, Jose Manuel Perez-Aguilar, Yu Chong, Xingfa Gao, Zhifang Chai, Chunying Chen*, Cuicui Ge*, and Ruhong Zhou*, Differential Pd-Nanocrystal Facets Demonstrate Distinct Antibacterial Activity against Gram-positive and Gram-negative Bacteria, Nature Communications, 9, 129, 2018 Yu Chong#, Xing Dai#, Ge Fang, Renfei Wu, Lin Zhao, Xiaochuan Ma, Xin Tian, Sangyun Lee, Chao Zhang, Chunying Chen, Zhifang Chai, Cuicui Ge*, and Ruhong Zhou*, Palladium Concave Nanocrystals with High-index Facets Accelerate Ascorbate Oxidation in Cancer Treatment, Nature Communications, 9, 4861, 2018 Alok V. Joglekar*, Zhe Liu, Jeffrey K. Weber, Yong Ouyang, John D. Jeppson, Won Jun Noh, Pedro A. Lamothe-Molina, Huabiao Chen, Seung-gu Kang, Michael T. Bethune, Ruhong Zhou*, Bruce D. Walker, David Baltimore*, HIV-specific T cell receptors from patients with differential immunologic control are functionally indistinguishable, Proc. Natl. Acad. Sci., 115, 1877-1882, 2018 Hongsuk Kang, Zaixing Yang, and Ruhong Zhou*, Lanosterol Disrupts Aggregation of Human γD-Crystallin by Binding to the Hydrophobic Dimerization Interface,J. Am. Chem. Soc. 140, 8479-8486, 2018 Daxiang Gui#, Xing Dai#, Zetian Tao#, Tao Zheng, Xiangxiang Wang, Mark A Silver, Jie Shu, Lanhua Chen, Yanlong Wang, Tiantian Zhang, Jian Xie, Lin Zou, Yuanhua Xia, Jujia Zhang, Jin Zhang, Ling Zhao*, Juan Diwu, Ruhong Zhou*, Zhifang Chai, Shuao Wang*, Unique Proton Transportation Pathway in a Robust Inorganic Coordination Polymer Leading to Intrinsically High and Sustainable Anhydrous Proton Conductivity, J. Am. Chem. Soc. 140, 6146-6155, 2018 Zonglin Gu#, Leigh D. Plant#, Xuan-Yu Meng*, Jose Manuel Perez-Aguilar, Zegao Wang, Mingdong Dong, Diomedes E. Logothetis*, and Ruhong Zhou*, Exploring the Nanotoxicology of MoS2: A Study on the Interaction of MoS2 Nanoflake and K+ Channels, ACS Nano, 12, 705-717, 2018 Binquan Luan* and Ruhong Zhou, Spontaneous Transport of Single-Stranded DNA through Graphene–MoS2 Heterostructure Nanopores,ACS Nano, 12, 3886-3891, 2018 Xuan-Yu Meng#, Seung-gu Kang#, Ruhong Zhou*,Molecular Mechanism of Phosphoinositides’ Specificity for the Inwardly Rectifying Potassium Channel Kir2. 2, Chem. Sci.9, 8352-8362, 2018 Lu Liu, Shitong Zhang, Lin Zhao, Zonglin Gu, Guangxin Duan, Bo Zhou, Zaixing Yang*, and Ruhong Zhou*, Superior Compatibility of C2N with Human Red Blood Cell Membranes and the Underlying Mechanism, Small, 14, DOI:10.1002/smll.201803509, 2018 Binquan Luan* and Ruhong Zhou, Single-File Protein Translocations through Graphene–MoS2 Heterostructure Nanopores, J. Phys. Chem. Lett.9, 3409–3415, 2018 Yunjie Zhou#, Yue Sun#, Cheng Zhu, Yang Liu, Xing Dai, Jun Zhong, Qiongyang Chen, He Tian*, Ruhong Zhou*, Zhenhui Kang*, C–O−–K+(Na+) groups in non-doped carbon as active sites for the oxygen reduction reaction, J. Mater. Chem. A 6, 8955-8961, 2018 Xia Wang#, Yanlong Wang#, Xing Dai, Mark A Silver, Wei Liu, Yuxiang Li, Zhuanling Bai, Daxiang Gui, Lanhua Chen, Juan Diwu, Ruhong Zhou, Zhifang Chai, Shuao Wang*, Phase transition triggered aggregation-induced emission in a photoluminescent uranyl–organic framework,Chem. Comm. 54, 627-630, 2018 Xiaochuan Ma#, Sangyun Lee#, Xingshu Fei, Ge Fang, Tien Huynh, Yu Chong, Zhifang Chai, Cuicui Ge*, Ruhong Zhou*, Inhibition of the proteasome activity by graphene oxide contributes to its cytotoxicity,Nanotoxicology, 12, 185-200, 2018 Jing Liu#, Seung-gu Kang#, Peng Wang, Yue Wang, Xiaonan Lv, Ying Liu, Fei Wang, Zonglin Gu, Zaixing Yang, Jeffrey K Weber, Ning Tao, Zhihai Qin, Qing Miao, Chunying Chen*, Ruhong Zhou*, Yuliang Zhao*, Molecular mechanism of Gd@C82(OH)22increasing collagen expression: Implication for encaging tumor, Biomaterials, 152, 24-36, 2018 David R. Bell#, Seung-gu Kang#, Tien Huynh, Ruhong Zhou*, Concentration-dependent binding of CdSe quantum dot on SH3 domain, Nanoscale, 10, 351-358, 2018 Serena H. Chen#, Seung-gu Kang#, Judong Luo*, Ruhong Zhou*, Charging Nanoparticles: Increased Binding of Gd@ C82 (OH) 22 Derivatives to Human MMP-9, Nanoscale, 10, 5667-5677, 2018 Dongfang Ma, Xuan-Yu Meng*, David R. Bell, Shengtang Liu, Ruhong Zhou*, Inhibition of CYP2C8 by metallofullerenol Gd@C82(OH)22through blocking substrate channels and substrate recognition sites, Carbon 127, 667-675, 2018 Wei Liu#, Xing Dai#, Jian Xie#, Mark Silver, Duo Zhang, Yanlong Wang, Yawen Cai, Juan Diwu, Jian Wang, Ruhong Zhou, Zhifang Chai, Shuao Wang*, Highly Sensitive Detecting of UV Radiation using a Uranium Coordination Polymer, ACS Appl. Mater. Interface,10, 4844–4850, 2018 Hao Li#, Jian Huang#, Yuxiang Song, Mengling Zhang, Huibo Wang, Fang Lu, Hui Huang, Yang Liu*, Xing Dai, Zonglin Gu, Zaixing Yang, Ruhong Zhou*, Zhenhui Kang*, Degradable carbon dots with broad-spectrum antibacterial activity, ACS Appl. Mater. Interface,10, 26936-26946, 2018 Zonglin Gu#, Wei Song#, Zaixing Yang, and Ruhong Zhou*, Metal-Organic Framework as an Efficient Filter for the Removal of Heavy Metal Cations in Water, Phys. Chem. Chem. Phys. 20, 30384 - 30391, 2018 Shulin Zhuang, Leili Zhang, Tingjie Zhan, Liping Lu, Lu Zhao, Haifei Wang, Joseph A Morrone, Weiping Liu*, Ruhong Zhou*, The Binding Specificity Determines the Cytochrome P450 3A4-Mediated Enantioselective Metabolism of Metconazole,J. Phys. Chem. B 122, 1176-1184, 2018 Jeffrey K Weber, Seung-gu Kang, Ruhong Zhou*, Rare Dissipative Transitions Punctuate the Initiation of Chemical Denaturation in Proteins, Biophys. J. 114, 812-821, 2018 Hong Zhou, Shengtang Liu, Qiwen Shao, Dongfang Ma, Zaixing Yang*, Ruhong Zhou*, Mechanism by which DHA inhibits the aggregation of KLVFFA peptides: A molecular dynamics study, J. Chem. Phys. 148, 115102, 2018 Hongsuk Kang, Binquan Luan, Ruhong Zhou*, Glassy dynamics in mutant huntingtin proteins, J. Chem. Phys. 149, 072333, 2018

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