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个人简介

Diplom University of Bonn (1989). PhD Technical University of Berlin (1992, S. Blechert); JSPS Fellow, Kyoto University (1993, K. Fuji). Habilitation, University of Basel (1999, B. Giese). Visiting Scientist, University of Toronto (1999). Visiting Scientist, Chuo University, Tokyo (2000). Visiting Scientist, Osaka University (2004). Visiting Scientist, Osaka Prefecture University (2008). Werner Prize, New Swiss Chemical Society (2000). Appointed as Professor of Organic Chemistry, Cardiff, in 2000.

研究领域

Design and Synthesis of New Chiral Selenium Electrophiles: high stereoselectivities are obtained with very simple and easily accessible reagents. Efficient polymer-bound selenium electrophiles with all the advantages in handling and work-up have been synthesized and used in various applications towards natural product synthesis. Development of New Hypervalent Iodine Reagents: hypervalent iodine compounds are versatile alternative reagents in reactions traditionally employing heavy metal complexes. The development of chiral reagents led to various new stereoselective reactions. Due to their high reactivity, even the functionalization of alkanes can be achieved under mild reaction conditions. Coordination of Chiral Ligands towards Electrophiles: we have developed a reagent-controlled stereoselective iodolactonization reaction applying a new method using a combination of ICl and a primary amine. Electrochemical Methods: The selective functionalization of alkenes by combining electrochemical methods with electrophilic reagents leads to promising catalytic reactions. The direct electron transfer at electrode surfaces is frequently referred to as one of the prototypical green technologies of the future. Microreactor Technology: The translation of both traditional flask-based chemistry and entirely new procedures on to chipbased platforms becomes more challenging as complexity of operation increases. We are developing new microreactors for reactions under segmented-flow conditions. Computational Chemistry: The evaluation of reaction pathways, transition states, intermediates and mechanisms by close interaction of theory and experiment on various levels is supporting many of the research areas mentioned above. In many areas of Synthetic Organic Chemistry reactions are needed, which produce in good yields stereochemically uniform compounds. In this respect many remarkable efforts have been undertaken and a variety of efficient as well as elegant stereochemical transformations using prochiral substrates are known. However, there are certain classes of compounds which cannot be efficiently used in these reactions. Only a few useful methods are known for the stereoselective functionalization of not or only weakly activated C-H bonds or C=C bonds. In our research projects we are investigating and developing stoichiometric and catalytic reactions leading to products with new stereogenic centers.

近期论文

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Wirth, T.et al. 2018. Enantioselective electrochemical lactonization using chiral iodoarenes as mediators. Synthesis (Stuttgart) (10.1055/s-0037-1610373) pdf Silva, F.et al. 2018. Short total synthesis of ajoene. Angewandte Chemie International Edition 57(38), pp. 12290-12293. (10.1002/anie.201808605) pdf Elsherbini, M. and Wirth, T. 2018. Hypervalent iodine reagents by anodic oxidation: a powerful green synthesis. Chemistry - a European Journal 24(51), pp. 13399-13407. (10.1002/chem.201801232) pdf Mironova, I. A.et al. 2018. Preparation and X-ray structure of 2-iodoxybenzenesulfonic acid (IBS) - a powerful hypervalent iodine(V) oxidant. Beilstein Journal of Organic Chemistry 14, pp. 1854-1858. (10.3762/bjoc.14.159) pdf Hokamp, T.et al. 2018. Alternative strategies with iodine: Fast access to new iodine(III) compounds. Angewandte Chemie International Edition 57(27), pp. 8306-8309. (10.1002/anie.201804642) pdf Elsherbini, M. and Wirth, T. 2018. Mechanochemical synthesis of N-tert-butanesulfinyl imines under metal-free conditions. Tetrahedron 74(25), pp. 3101-3106. (10.1016/j.tet.2017.11.028) pdf Singh, F. V. and Wirth, T. 2018. Stereoselective Reactions. John Wiley. (10.1002/9780470682531.pat0957) Silva, F.et al. 2018. Selective oxidation of sulfides in flow chemistry. European Journal of Organic Chemistry 2018(18), pp. 2134-2137. (10.1002/ejoc.201800339) pdf Soldatova, N.et al. 2018. One-pot synthesis of diaryliodonium salts from arenes and aryl iodides with Oxone-sulfuric acid. Beilstein Journal of Organic Chemistry 14, pp. 849-855. (10.3762/bjoc.14.70) pdf Yusubov, M.et al. 2018. Reactions of 1-arylbenziodoxolones with azide anion: Experimental and computational study of substituent effects. European Journal of Organic Chemistry 2018(5), pp. 640-647. (10.1002/ejoc.201701595) pdf Folgueiras-Amador, A. A.et al. 2018. Catalyst- and supporting electrolyte-free electrosynthesis of benzothiazoles and thiazolopyridines in continuousf flow. Chemistry - A European Journal 24(2), pp. 487-491. (10.1002/chem.201705016) pdf Wirth, T. 2018. Organoselenium Chemistry. Wiley. (10.1002/9781119951438) pdf Wirth, T. 2017. Integration of flow chemistry in multistep syntheses. European Journal of Organic Chemistry 2017(44), pp. 6464. (10.1002/ejoc.201701543) pdf Wirth, T. 2017. Thomas Wirth. European Journal of Organic Chemistry 2017(44), pp. 6465-6464. (10.1002/ejoc.201701545) pdf Wirth, T. 2017. Organic synthesis in flow for medicinal chemistry. Bioorganic & Medicinal Chemistry 25(23), pp. 6179. (10.1016/j.bmc.2017.11.013) pdf Aldmairi, A. H., Knight, D. and Wirth, T. 2017. Acid-catalyzed tandem process for the one-pot synthesis of oxazolidines. Synlett 28(20), pp. 2976-2978. (10.1055/s-0036-1591513) pdf Wirth, T. and Singh, F. V. 2017. 2.2 Catalytic oxidations with hypervalent iodine. In: Muniz, K. ed. Science of Synthesis: Catalytic Oxidation in Organic Synthesis. Thieme, pp. 29-62.

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