Tsai, Yuhsuan - Cardiff University

个人简介

BSc, National Taiwan University (2003-2006); MSc, Eidgenossische Technische Hochschule (ETH) Zurich (2007-2008); Dr. rer. nat., Freie Universitat Berlin (2009-2012, P. H. Seeberger). Research Assistant, Academia Sinica (2006-2007, S.-H. Wu); MRC Career Development Fellow and EMBO Fellow, MRC Laboratory of Molecular Biology (2012-2014, J. W. Chin). Appointed Lecturer, Cardiff (2015).

研究领域

My research interests include: Synthesis of biological important molecules Study of protein functions by genetic incorporation of unnatural amino acids

近期论文

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Gotze, S.et al. 2015. Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a toxoplasma gondii mouse challenge model. Glycobiology 25(9), pp. 984-991. (10.1093/glycob/cwv040) Tsai, Y.et al. 2015. Selective, rapid and optically switchable regulation of protein function in live mammalian cells. Nature Chemistry 7, pp. 554-561. (10.1038/nchem.2253) Götze, S.et al. 2014. Diagnosis of toxoplasmosis using a synthetic glycosylphosphatidylinositol glycan. Angewandte Chemie - International Edition 53(50), pp. 13701-13705. (10.1002/anie.201406706) Tsai, Y.et al. 2013. A general and convergent synthesis of diverse glycosylphosphatidylinositol glycolipids. Chemical Science 4(1), pp. 468-481. (10.1039/C2SC21515B) Tsai, Y., Liu, X. and Seeberger, P. H. 2012. Chemical biology of glycosylphosphatidylinositol anchors. Angewandte Chemie - International Edition 51(46), pp. 11438-11456. (10.1002/anie.201203912) Tsai, Y.et al. 2012. Glycosylphosphatidylinositols of protozoan parasites. Trends in Glycoscience and Glycotechnology 24(140), pp. 231-243. (10.4052/tigg.24.231) Tsai, Y.et al. 2011. A general method for synthesis of GPI anchors illustrated by the total synthesis of the low-molecular-weight antigen from toxoplasma gondii. Angewandte Chemie - International Edition 50(42), pp. 9961-9964. (10.1002/anie.201103483) Yang, Y.et al. 2010. Structural variation of glycolipids from Meiothermus taiwanensis ATCC BAA-400 under different growth temperatures. Organic & Biomolecular Chemistry 8(19), pp. 4252-4254. (10.1039/c0ob00169d) Kikkeri, R.et al. 2010. Facile synthesis of size dependent Ru(ii)?carbohydrate dendrimers via click chemistry. Chemical Communications 46(13), pp. 2197-2199. (10.1039/b925113h) Hecht, M.et al. 2010. Synthetic inositol phosphoglycans related to GPI lack insulin-mimetic activity. ACS Chemical Biology 5(11), pp. 1075-1086. (10.1021/cb1002152) Oberli, M.et al. 2010. Molecular analysis of carbohydrate−antibody interactions: case study using a bacillus anthracis tetrasaccharide. Journal of the American Chemical Society 132(30), pp. 10239-10241. (10.1021/ja104027w) Ren, C.et al. 2007. Synthesis of a tetrasaccharide glycosyl glycerol. Precursor to glycolipids of meiothermus taiwanensis ATCC BAA-400. Journal of Organic Chemistry 72(14), pp. 5427-5430. (10.1021/jo070629l)