Richards, Nigel - Cardiff University

个人简介

B.Sc. (Hons.), Imperial College, University of London (1980), PhD Cambridge University (1980-83). Commonwealth Foundation (Harkness) Postdoctoral Research Fellow, Columbia University, New York (1983-1985), University Lecturer Department of Chemistry, University of Southampton (1985-1990), Assistant Professor in Chemistry, University of Florida (1990-1996), Associate Professor in Chemistry, University of Florida (1996-2003), Full Professor in Chemistry, University of Florida (2003-2012), Fellow of the American Association for the Advancement of Science (2010), Full Professor and Chair, Department of Chemistry & Chemical Biology, Indiana University Purdue University Indianapolis (2012-2015). Since 2015: Professor of Biological Chemistry, Cardiff School of Chemistry.

研究领域

The Richards laboratory studies the relationship between the structure and function of enzymes that either catalyze chemically interesting reactions or are potential targets for the development of drugs against cancer or tuberculosis. In addition, several projects aimed at creating new tools for synthetic biology are underway, with an emphasis on enzymes that can manipulate DNA and RNA containing expanded genetic alphabets both in vitro and in live cells. Our work relies on an interdisciplinary approach at the interface of chemistry, physical organic chemistry, biophysics, biochemistry, molecular and cellular biology and medicinal chemistry and involves a wide range of techniques. For more information, click on the 'Research' tab above.

近期论文

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Jin, Y.et al. 2017. Metal fluorides as analogues for studies on phosphoryl transfer enzymes. Angewandte Chemie - International Edition 56(15), pp. 4110-4128. (10.1002/anie.201606474) pdf Molt, R., Georgiadis, M. M. and Richards, N. G. J. 2017. Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulations. Nucleic Acids Research (10.1093/nar/gkx144) pdf Blackburn, G.et al. 2016. Metal fluorides as analogs for studies on phosphoryl transfer enzymes. Angewandte Chemie (10.1002/ange.201606474) pdf Kumar, A.et al. 2016. Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives. Chemical Society Reviews 45(24), pp. 6855-6887. (10.1039/C6CS00147E) pdf Molt, R.et al. 2016. Gas phase RDX decomposition pathways using coupled cluster theory. Physical Chemistry Chemical Physics 18(37), pp. 26069-26077. (10.1039/C6CP05121A) pdf Zhu, W.et al. 2016. Substrate binding mode and molecular basis of a specificity switch in oxalate decarboxylase. Biochemistry 85(14), pp. 2163-2173. (10.1021/acs.biochem.6b00043) pdf Kumar, P.et al. 2016. Microwave-assisted, metal-free, base-mediated C-N bond formation/cleavage: synthesis of benzimidazo[1,2-a]quinazoline derivatives. ACS Sustainable Chemistry & Engineering 4(4), pp. 2206-2210. (10.1021/acssuschemeng.5b01669) Zhu, W.et al. 2016. Formation of hexacoordinate Mn(III) in Bacillus subtilis oxalate decarboxylase requires catalytic turnover. Biochemistry 55(3), pp. 429-434. (10.1021/acs.biochem.5b01340) Jin, Y.et al. 2016. 19F NMR and DFT analysis reveal structural and electronic transition state features for RhoA-catalyzed GTP hydrolysis. Angewandte Chemie - International Edition 55(10), pp. 3318-3322. (10.1002/anie.201509477) pdf Sharma, P.et al. 2016. Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids. Journal of Enzyme Inhibition and Medicinal Chemistry 31(6), pp. 1520-1526. (10.3109/14756366.2016.1151015) Vladimirova, A.et al. 2016. Substrate distortion and the catalytic reaction mechanism of 5-carboxyvanillate decarboxylase. Journal of the American Chemical Society 138(3), pp. 826-836. (10.1021/jacs.5b08251) pdf Hettmer, S.et al. 2015. Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. eLife 4, article number: e09436.. (10.7554/eLife.09436) pdf