Redman, James - Cardiff University

个人简介

PhD University of Cambridge (2000, J. K. M. Sanders, self-assembly of porphyrins). Wellcome Trust Travelling Research Fellowship (2000-3). Research Fellow, Scripps Research Institute (2000-2, M. R. Ghadiri, protein design and mass spectrometry of cyclic peptides). Research Associate, University of Cambridge (2002-6, S. Balasubramanian, recognition of guanine quadruplexes by proteins and small molecules). Appointed as Lecturer, Cardiff, in 2006.

研究领域

Dr Redman's research interests are in the areas of amino acid, protein and peptide chemistry, nucleic acids and mass spectrometry. This work involves the synthesis of amino acids with heterocyclic side chains designed as building blocks for nucleic acid-binding peptides. We are preparing amino acids with mono- and bicyclic guanidine side chains as constrained analogues of arginine that are predicted to form hydrogen bonded interactions with nucleobases. Peptides can also be constrained by backbone cyclisation and we are investigating the use of computer aided interpretation of collision induced dissociation mass spectra of cyclic peptides as a tool for characterisation of this class of compound. A further project involves using phage display techniques to select allosteric DNA binding proteins, with the goal of creating artificial transcription factors that can be switched using a small molecule drug.

近期论文

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Reid, R.et al. 2015. CD8+ T-cell recognition of a synthetic epitope formed by t-butyl modification. Immunology 144(3), pp. 495-505. (10.1111/imm.12398) pdf Reid, R.et al. 2015. CD8+T-cell recognition of a synthetic epitope formed byt-butyl modification. Immunology 144(3), pp. 495-505. (10.1111/imm.12398) Möschwitzer, V. D., Kariuki, B. and Redman, J. E. 2013. Asymmetric synthesis of aminopyrimidine and cyclic guanidine amino acids. Tetrahedron Letters 54(34), pp. 4526-4528. (10.1016/j.tetlet.2013.06.066) Michael, D.et al. 2011. The human hyaluronan synthase 2 (HAS2) gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell. Journal of Biological Chemistry 286(22), pp. 19523-19532. (10.1074/jbc.M111.233916) Rouziere, A. and Redman, J. E. 2011. A practical workshop for generating simple DNA fingerprints of plants. Biochemistry and Molecular Biology Education 39(3), pp. 204-210. (10.1002/bmb.20486) Jenkins, R.et al. 2010. A conserved stem loop motif in the 5'Untranslated Region regulates transforming growth factor-β1 translation. PLoS One 5(8), article number: e12283. (10.1371/journal.pone.0012283) pdf Redman, J.et al. 2009. Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. Organic & Biomolecular Chemistry 7(1), pp. 76-84. (10.1039/b814682a) Redman, J. E. 2007. Surface plasmon resonance for probing quadruplex folding and interactions with proteins and small molecules. Methods 43(4), pp. 302-312. (10.1016/j.ymeth.2007.05.008) Ladame, S.et al. 2006. Exploring the Recognition of Quadruplex DNA by an Engineered Cys2-His2 Zinc Finger Protein. Biochemistry 45(5), pp. 1393-1399. (10.1021/bi050229x) Yadav, M.et al. 2005. Structure-Based Engineering of Internal Cavities in Coiled-Coil Peptides. Biochemistry 44(28), pp. 9723-9732. (10.1021/bi050742a) Redman, J. E., Wilcoxen, K. M. and Ghadiri, M. R. 2002. Automated Mass Spectrometric Sequence Determination of Cyclic Peptide Library Members. Journal of Combinatorial Chemistry 5(1), pp. 33-40. (10.1021/cc0200639) Cousins, G.et al. 2001. Identification and Isolation of a Receptor for N-Methyl Alkylammonium Salts: Molecular Amplification in a Pseudo-peptide Dynamic Combinatorial Library. Angewandte Chemie International Edition 40(2), pp. 423-428. (10.1002/1521-3773(20010119)40:2<423::AID-ANIE423>3.0.CO;2-6)