Morrill, Louis - Cardiff University

个人简介

Louis was born in Wick on the north coast of Scotland and obtained his MChem degree (1st Class Honours) from the University of St Andrews, including a one-year industrial placement at AstraZeneca (Charnwood). He completed his Masters research project in 2010 with Professor Andrew Smith. Staying at St Andrews, he completed his Ph.D. under the direction of Professor Andrew Smith entitled "Organocatalytic Functionalisation of Carboxylic Acids Using Isothioureas", funded by a prestigious Carnegie-Caledonian Scholarship (2010-2014). This work expanded the utility of isothioureas in Lewis base catalysis and demonstrated the first intermolecular bond-forming reaction of carboxylic acid-derived ammonium enolates For his postdoctoral research, he moved to UC Berkeley to join the research group of Professor Richmond Sarpong, entering the world of complex molecule synthesis. Specifically, he was part of a team that developed highly efficient and concise total syntheses of diterpenoid alkaloid natural products. In 2015, he was appointed as a University Research Fellow in Synthetic Organic Chemistry at Cardiff University and began his independent research career. He is specifically interested in exploring new frontiers in organocatalysis.

研究领域

Research in the Morrill group is focused in the field of Synthetic Organic Chemistry. We are particularly interested in exploring new frontiers in organocatalysis, employing dual catalytic methods to rapidly generate molecular complexity, forming densely functionalised molecules in a stereodefined fashion. The multi-step, one-pot nature of this dual catalysis approach represents progress towards more sustainable chemistry. The development of novel organocatalysts, especially those that operate via unusual or previously unknown modes of activation, represents another significant area of interest. The utility and impact of our developed methodologies will ultimately be exemplified through its application in the total synthesis of natural products and molecules of biological significance.

近期论文

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Ayres, J., Ling, K. B. and Morrill, L. 2016. N-Cyanation of secondary amines using Trichloroacetonitrile. Organic Letters 18(21), pp. 5528-5531. (10.1021/acs.orglett.6b02775) pdf Smith, A.et al. 2016. Enantioselective synthesis of 3,5,6-substituted dihydropyranones and dihydropyridinones using isothiourea-mediated catalysis. Chemistry - An Asian Journal 11(3), pp. 395-400. (10.1002/asia.201500907) Smith, S.et al. 2015. Asymmetric isothiourea-catalysed formal [3+2] cycloadditions of ammonium enolates with oxaziridines. Chemistry - a European Journal 21(29), pp. 10530-10536. (10.1002/chem.201501271) Morrill, L.et al. 2015. Isothiourea-catalyzed Michael Addition to unsaturated trichloromethyl ketones. Synfacts 11(03), article number: 0315. (10.1055/s-0034-1380058) Campbell, C.et al. 2015. Regiodivergent Lewis base-promoted O- to C-carboxyl transfer of furanyl carbonates. Organic & Biomolecular Chemistry 13(10), pp. 2895-2900. (10.1039/C4OB02629B) Millet, A., Baudoin, O. and Morrill, L. 2015. Palladium-catalyzed β -Selective C(sp3)-H Arylation of N-Boc-Piperidines. Organic Syntheses 92, pp. 76-90. (10.15227/orgsyn.092.0076) Morrill, L. and Smith, A. D. 2014. Organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium or azolium enolates. Chemical Society Reviews 43(17), pp. 6214-6226. (10.1039/C4CS00042K) Morrill, L.et al. 2014. Isothiourea-mediated asymmetric functionalization of 3-alkenoic acids. Journal of Organic Chemistry 79(4), pp. 1640-1655. (10.1021/jo402591v) Morrill, L.et al. 2014. Organocatalytic Michael addition–lactonisation of carboxylic acids using α,β-unsaturated trichloromethyl ketones as α,β-unsaturated ester equivalents. Organic & Biomolecular Chemistry 12(44), pp. 9016-9027. (10.1039/C4OB01788A) Morrill, L.et al. 2014. 2-Arylacetic anhydrides as ammonium enolate precursors. Organic & Biomolecular Chemistry 12(4), pp. 624-636. (10.1039/C3OB41869C) De Savi, C.et al. 2014. Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. Journal of Medicinal Chemistry 57(11), pp. 4661-4676. (10.1021/jm5001216) Stark, D.et al. 2013. Isothiourea-mediated one-pot synthesis of functionalized pyridines. Angewandte Chemie - International Edition 52(44), pp. 11642-11646. (10.1002/anie.201306786)