Luk, Louis - Cardiff University - School of Chemistry

个人简介

BSc Chemistry and Microbiology & Immunology, University of British Columbia (1999-2004) PhD Chemistry, University of British Columbia (2004-2010, M.E. Tanner) Postdoctoral Research Fellow, University of Chicago (2010-2011, S.B.H. Kent) Postdoctoral Research Associate, Cardiff University (2012-2015, R.K. Allemann) Research Fellow (2015)

研究领域

Our research aims to use advanced chemical biology and synthetic biology techniques to solve enzymology questions that are of medicinal and industrial importance. Our research programs will provide comprehensive training in various aspects of chemistry and biology. These studies can also lead to the production of biologically active and/or industrially useful compounds, and data obtained for these projects will be published in peer-reviewed journals.

近期论文

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Loveridge, E.et al. 2017. Reduction of folate by dihydrofolate reductase from thermotoga maritima. Biochemistry 56(13), pp. 1879-1886. (10.1021/acs.biochem.6b01268) pdf Angelastro, A.et al. 2016. A versatile disulfide-driven recycling system for NADP+ with high cofactor turnover number. ACS Catalysis 7, pp. 1025-1029. (10.1021/acscatal.6b03061) pdf Castillo, J.et al. 2016. β1 subunit-induced structural rearrangements of the Ca2+- and voltage-activated (BK) channel. Proceedings of the National Academy of Sciences of the United States of America 113(23), pp. E3231-E3239. (10.1073/pnas.1606381113) pdf Ruiz-Pernía, J.et al. 2016. Minimization of dynamic effects in the evolution of dihydrofolate reductase. Chemical Science 7(5), pp. 3248-3255. (10.1039/C5SC04209G) pdf Luk, L.et al. 2015. Chemical ligation and isotope labeling to locate dynamic effects during catalysis by dihydrofolate reductase. Angewandte Chemie - International Edition 54(31), pp. 9016-9020. (10.1002/anie.201503968) pdf Luk, L. Y. P., Loveridge, E. J. and Allemann, R. K. 2015. Protein motions and dynamic effects in enzyme catalysis. Physical Chemistry Chemical Physics 17, pp. 30817-30827. (10.1039/C5CP00794A) pdf Luk, L.et al. 2014. Protein isotope effects in dihydrofolate reductase from Geo-bacillus stearothermophilus show entropic-enthalpic com-pensatory effects on the rate constant. Journal of the American Chemical Society 136(49), pp. 17317-17323., article number: 141114165738006. (10.1021/ja5102536) pdf Guo, J.et al. 2014. Thermal adaptation of dihydrofolate reductase from the moderate thermophile geobacillus stearothermophilus. Biochemistry 53(17), pp. 2855-2863. (10.1021/bi500238q) pdf Luk, L. Y. P., Loveridge, E. J. and Allemann, R. K. 2014. Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases. Journal of the American Chemical Society 136(19), pp. 6862-6865. (10.1021/ja502673h) pdf Behiry, E.et al. 2014. Role of the occluded conformation in bacterial dihydrofolate reductases. Biochemistry 53(29), pp. 4761-4768. (10.1021/bi500507v) pdf Ruiz-Pernia, J.et al. 2013. Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase. Journal of the American Chemical Society 135(49), pp. 18689-18696. (10.1021/ja410519h) pdf Luk, L.et al. 2013. Unraveling the role of protein dynamics in dihydrofolate reductase catalysis. Proceedings of the National Academy of Sciences of the United States of America 110(41), pp. 16344-16349. (10.1073/pnas.1312437110) Guo, J.et al. 2013. Effect of dimerization on dihydrofolate reductase catalysis. Biochemistry 52(22), pp. 3881-3887. (10.1021/bi4005073)