Casini, Angela - Cardiff University

个人简介

PhD in Chemical Sciences at the University of Florence (2004). Postdoctoral fellow at the Dulbecco Telethon Institute, University of Pisa (2004-2005). Principal Investigator at the École polytechnique fédérale de Lausanne (EPFL) funded by the Swiss National Science Foundation (SNF, "Ambizione" program) (2008-2011). Assistant professor at the University of Groningen and Rosalind Franklin Fellow (2011-2015). Since 2015: Chair of Medicinal and Bioinorganic Chemistry, Cardiff School of Chemistry. 2012 European Medal for Biological Inorganic Chemistry (EUROBIC11 award -11th European Biological Inorganic Chemistry Conference); 2014 Early career investigator at the Gordon Research Conference Metals in Medicine "New Frontiers". 2016 August-Wilhelm Scheer Visiting Professorship at the Technical University of Munich (TUM) and “Honorary Fellow” of the prestigious institute for Advanced Study of TUM (IAS-TUM). Listed by Thomson Reuters as one of the "Worlds most influential scientific minds of 2014" in the field of Pharmacology.

研究领域

Our research interests are in Medicinal Inorganic and Bioinorganic Chemistry. In particular the study of the role of metal ions in biological systems and of the mechanisms of action of metal-based anticancer agents are active topics of our research program. Besides synthetic inorganic chemistry and structural characterization of new metal complexes, we strongly focus on an intensive biological evaluation of the new compounds as possible therapeutic agents, and on the investigation of their mechanisms of action via the implementation of biophysical and analytical techniques coupled to pharmacological methods. Furthermore, novel applications for metal-based compounds/scaffolds are explored in various domains of chemical biology, bio-analytical chemistry and physiology. For more information, click on the 'Research' tab above. The main topics developed in our lab include: Design and synthesis of coordination and organometallic gold complexes for biological applications: as therapeutic agents and chemical probes. Molecular investigations of metal compounds' interactions with biologically active ligands (e.g. proteins, nucleic acids) Development of supramolecular assemblies as drug delivery systems. Synthesis of photoactivable metal compounds. Development of chemical strategies to couple metal compounds to biomolecules.

近期论文

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Wenzel, M. and Casini, A. 2017. "Mass spectrometry as a powerful tool to study therapeutic metallodrugs speciation mechanisms: current frontiers and perspectives". Coordination Chemistry Reviews (10.1016/j.ccr.2017.02.012) pdf Medrano, M.et al. 2017. Non-conventional trans-platinum complexes functionalized with RDG peptides: chemical and cytototoxicity studies. European Journal of Inorganic Chemistry (10.1002/ejic.201700072) pdf Han, J.et al. 2017. Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications. Chemical Communications (10.1039/C6CC08937B) pdf Muenzner, J.et al. 2016. Ferrocenyl-coupled n-heterocyclic carbene complexes of gold(i): a successful approach to multinuclear anticancer drugs. Chemistry - a European Journal 22(52), pp. 18953-18962. (10.1002/chem.201604246) pdf Hahn, E.et al. 2016. Functionalization of Ruthenium(II) terpyridine complexes with cyclic RGD peptides to target integrin receptors in cancer cells. European Journal of Inorganic Chemistry (10.1002/ejic.201601094) pdf Kaiser, F.et al. 2016. Self-assembled palladium and platinum coordination cages: Photophysical studies and anticancer activity. European Journal of Inorganic Chemistry 2016(33), pp. 5189-5196. (10.1002/ejic.201600811) pdf Gabbiani, C.et al. 2016. Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells. Journal of Inorganic Biochemistry 163, pp. 318-322. (10.1016/j.jinorgbio.2016.06.024) pdf Soveral, G. and Casini, A. 2016. Aquaporin modulators: a patent review (2010-2015). Expert Opinion on Therapeutic Patents (10.1080/13543776.2017.1236085) pdf Citta, A.et al. 2016. Toward anticancer gold-based compounds targeting PARP-1: a new case study. RSC Advances 6(82), pp. 79147-79152. (10.1039/C6RA11606J) pdf Schmidt, A.et al. 2016. Self-assembly of highly luminescent heteronuclear coordination cages. Dalton Transactions (10.1039/C6DT02708C) pdf