Buurma, Niklaas - Cardiff University

个人简介

MSc (1997) and PhD (both cum laude), University of Groningen (2003, J. B. F. N. Engberts). Postdoctoral Research Fellow, University of Sheffield (2002-2006, C. A. Hunter and I. Haq). Appointed Lecturer in Physical Organic Chemistry, Cardiff, in 2006. Member of the Royal Society of Chemistry, Fellow of the Higher Education Academy. Member of the RSC Physical Organic Chemistry Group committee. Unilever Research Prize 1998.

研究领域

Dr Buurma's research is aimed at understanding reactions and interactions in aqueous solutions in order to control processes in water and is focused on two main areas. The first area involves the development of conjugated DNA-binders with interesting optoelectronic properties for molecular diagnostics and therapeutic purposes as well as for use in self-assembled nanobioelectronic systems. Our contributions to this area include the synthesis of news DNA-binding compounds and subsequent studies of their DNA-binding properties as well as the development of data-analysis software for the analysis of isothermal titration calorimetry (ITC) data for complex coupled equilibria. The second area of interest involves the study of organic reactions in aqueous solutions. We currently focus on studies of micellar medium effects, kinetic and mechanistic studies of surfactant-assisted metal-catalysed as well as nanoparticle-catalysed reactions. In addition, we study pharmaceutically relevant racemisation processes (in collaboration with AstraZeneca). The ultimate aim of all our projects is to develop and use our ability to control and direct reactions and interactions in aqueous solution, bringing chemistry, (nano)engineering and nature together.

近期论文

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Saeed, H.et al. 2017. The structure of linkers affects the DNA binding properties of tethered dinuclear ruthenium (II) metallo-intercalators. Chemistry - a European Journal (10.1002/chem.201605750) pdf Cao, T.et al. 2017. Investigation of the interactions between methylene blue and intramolecular G-quadruplexes: an explicit distinction in electrochemical behavior. Analyst (10.1039/C7AN00083A) pdf Pritchard, M.et al. 2017. The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Scientific Reports Hahn, L., Buurma, N. J. and Gade, L. H. 2016. A water-soluble tetraazaperopyrene dye as strong G-quadruplex DNA binder. Chemistry - a European Journal 22(18), pp. 6314-6322. (10.1002/chem.201504934) pdf Zheng, G.et al. 2014. Palladium nanoparticle-loaded cellulose paper: a highly efficient, robust, and recyclable self-assembled composite catalytic system. The Journal of Physical Chemistry Letters 6(2), pp. 230-238. (10.1021/jz5024948) pdf Regan, E.et al. 2014. A novel cobalt complex for enhancing amperometric and impedimetric DNA detection. Electrochimica Acta 128, pp. 10-15. (10.1016/j.electacta.2013.10.028) pdf Salvia, M.et al. 2013. Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove. Biophysical Chemistry 179, pp. 1-11. (10.1016/j.bpc.2013.04.001) Postolachi, R.et al. 2013. New cycloimmonium ylide ligands and their palladium(ii) affinities. RSC Advances 3(38), pp. 17260-17270. (10.1039/c3ra41911h) Dávila-Ibáñez, A. B., Buurma, N. J. and Salgueiriño, V. 2013. Assessment of DNA complexation onto polyelectrolyte-coated magnetic silica nanoparticles. Nanoscale 5(11), pp. 4797-4807. (10.1039/c3nr34358h) Buurma, N. J. 2012. Reactivity in organised assemblies. Annual Reports Section "B" (Organic Chemistry) 108, pp. 316-333. (10.1039/c2oc90021a) Saad, F.et al. 2012. Co-ordination behaviour of a novel bisthiourea tripodal ligand: structural, spectroscopic and electrochemical properties of a series of transition metal complexes. Dalton Transactions 41(15), pp. 4608-4617. (10.1039/c2dt11732k) Fujii, S.et al. 2012. Polypyrrole-palladium nanocomposite coating of micrometer-sized polymer particles toward a recyclable catalyst. Langmuir 28(5), pp. 2436-2447. (10.1021/la204324f) Leach, A.et al. 2012. Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain. MedChemComm 3(5), pp. 528-540. (10.1039/c2md20010d)