Browne, Duncan - Cardiff University

个人简介

Duncan was born in Dunstable, UK. He graduated with a MChem degree (1st class, Hons) Chemistry with study in industry from the University of Sheffield during which time he spent one year as an intern at GSK, Stevenage, UK, working in the metabolic and viral disease group. In 2009 he graduated from the same institution with a Ph.D. in Organic Synthesis (with Professor Joseph P. A. Harrity) where he worked on the development of strategies for the synthesis of pyrazole libraries, particularly through alkynylboronate cycloadditions with sydnones. During this time he spent 3 months at Syngenta, Jealotts Hill, UK, on a CASE placement working with John Taylor and Andrew Plant. Following his Ph.D. he was awarded a one year Doctoral Prize Fellowship from the EPSRC and studied benzyne cycloaddition chemistry. In 2010 he moved to the ITC and Whiffen Laboratories at the University of Cambridge as a Postdoctoral Research Associate with Professor Steven V. Ley FRS CBE. There he enjoyed developing new flow chemistry tools, techniques and synthetic methods as well as applying them to industrially relevant processing problems. In 2012 Duncan was appointed as a Fellow in Natural Sciences at Sidney Sussex College (University of Cambridge), and, in 2013 he was made Director of Studies in Natural Sciences. In September 2014, Duncan established his independent research group and became Lecturer in Organic Synthesis at Cardiff University.

研究领域

Continuous Flow Chemistry - An optimised continuous flow process can provide chemicals 'on-demand' with excellent reproducibility. We are currently developing multistep or telescoped flow processes to Fine Chemicals, Pharmaceuticals and Agrochemicals. We are also developing tools for synthesis chemists to collect relevant process data for chemical engineers. Mechanochemical Synthesis - Mechanochemistry is a solvent-free solid-state grinding technique. Our work in this area is focussed on identifying new concepts for synthesis and searching for phenomena that are unattainable by other means. In tandem with this we are looking to identify reaction processes where solvent use is minimised for workup and purification as well as the reaction. Under-represented Fluorous Motifs - The chance of achieving a successful ‘hit’ in the search for new and improved functional organic molecules can be increased by appropriate fluorination. Fluorinated organic molecules can offer improved properties compared to their non-fluorous congeners. We are particularly interested in designing new methods to access under-represented organofluorine motifs. Valorisation of Renewable or Waste Materials - Biofeedstocks in general and biowaste in particular represent an attractive source of useful chemical functionality, which to date is still largely untapped in terms of its application in the fine chemicals industry. We have identified continuous flow methods as a must use technology for the valorisation of such materials so that any designed methods can be rapidly scaled to manufacture. Manufacturing the Future – The key goal of exploring the capabilities of enabling technologies is to streamline the delivery of new chemical discoveries from the discovery phase to manufactured products. We would like to develop more versatile, flexible and modular chemical manufacturing systems, as well as a significant push towards solvent free manufacturing processes.

近期论文

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Howard, J.et al. 2017. Controlling reactivity through liquid assisted grinding: the curious case of mechanochemical fluorination. Green Chemistry (10.1039/C6GC03139K) pdf Schotten, C.et al. 2016. Protected diazonium salts: a continuous-flow preparation of triazenes including the anticancer compounds dacarbazine and mitozolomide. Journal of Flow Chemistry (10.1556/1846.2016.00025) pdf Browne, D.et al. 2016. Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation. Organic & Biomolecular Chemistry 14(25), pp. 5983-5991. (10.1039/C6OB00970K) pdf Howard, J.et al. 2016. Preparation of difluoromethylthioethers through difluoromethylation of disulfides using TMS-CF2H. Chemical Communications 52, pp. 8448-8451. (10.1039/C6CC02693A) pdf Poh, J., Browne, D. L. and Ley, S. V. 2016. A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. Reaction Chemistry and Engineering (10.1039/C5RE00082C) Browne, D. L. 2015. Flow chemistry. Green Processing and Synthesis 4(3), pp. 253. (10.1515/gps-2015-0027) Schotten, C.et al. 2015. Continuous flow metathesis for direct valorization of food waste: an example of cocoa butter triglyceride. ACS Sustainable Chemistry & Engineering 3(7), pp. 1453-1459., article number: 150603072518002. (10.1021/acssuschemeng.5b00397) pdf Zhou, Y.et al. 2015. Discovery of new metastable polymorphs in a family of urea co-crystals by solid-state mechanochemistry. Crystal Growth and Design 15(6), pp. 2901-2907. (10.1021/acs.cgd.5b00331) Deadman, B.et al. 2015. Back pressure regulation of slurry-forming reactions in continuous flow. Chemical Engineering & Technology 38(2), pp. 259-264. (10.1002/ceat.201400445) Browne, D. L. 2014. Cluster preface: progress in organo-fluorine chemistry. Synlett 26(01), pp. 33-35. (10.1055/s-0034-1379721) Newby, J.et al. 2014. Reconfiguration of a continuous flow platform for extended operation: application to a cryogenic fluorine-directedortho-lithiation reaction. Organic Process Research and Development 18(10), pp. 1221-1228. (10.1021/op500221s) Kabeshov, M.et al. 2014. Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology. Organic Letters 16(17), pp. 4618-4621. (10.1021/ol502201d)