Allemann, Rudolf - Cardiff University

个人简介

Dipl. Chem. ETH (B.Sc.), Eidgenössische Technische Hochschule (ETH), Zürich (1985), PhD Harvard University / ETH Zürich (1986-89). Royal Society and Swiss National Science Foundation Postdoctoral Research Fellow, MRC-National Institute for Medical Research, Mill Hill (1989-1990), Staff Scientist MRC-National Institute for Medical Research, Mill Hill (1990-1992), Research group leader, Department of Chemistry, ETH-Zürich and Lecturer (Lehrbeauftragter) in Biological Chemistry (1992-1998), Habilitation, Department of Chemistry, ETH Zürich(1999), Senior Lecturer in Chemistry, University of Birmingham (1999-2001), Professor of Chemical Biology, University of Birmingham (2001-2004), Since 2005: Distinguished Research Professor and Head of Chemical Biology, Cardiff School of Chemistry.

研究领域

The Allemann laboratory studies the relationship between the structure and function of enzymes and develops and applies chemical tools to probe biological processes in vitro and in live cells. Our work relies on an interdisciplinary approach at the interface of chemistry, physical organic chemistry, biophysics, synthetic biology, biochemistry, molecular and cellular biology and medicinal chemistry and involves a wide range of techniques. Based on an understanding of enzymatic catalysis and mechanism we develop tools that mimic Nature's reagents. The main research themes are Physical and Chemical Basis of Enzyme Catalysis The high chemical selectivity and specificity as well as the enormous rate accelerations relative to the uncatalysed reactions are studied in a multi-disciplinary approach. Synthetic Biology Synthetic Biology capitalises on the advances in genomics and proteomics and the new insights into the molecular mechanisms of action brought about by fundamental chemical and physical studies. Our projects aim to redesign existing, natural biological systems for useful purposes and to design de novo new biological components, devices and systems. They include the design and application of miniature enzymes, the photonic control of biomacromolecular structure to regulate cellular events and approaches for an expansion of the pool of secondary metabolites. Medicinal Chemistry Small molecule chemistry together with mechanistic studies of enzymes for the development of selective inhibitors for a variety of autoimmune diseases such as osteoarthritis. Organic Chemistry Diversity Oriented Synthesis; synthesis of novel 'terpenoids', carbohydrate derivatives and biophotonic nanoswitches.

近期论文

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Tang, X., Allemann, R. K. and Wirth, T. 2017. Optimising terpene synthesis with flow biocatalysis. European Journal of Organic Chemistry 2017(2), pp. 414-418. (10.1002/ejoc.201601388) pdf Angelastro, A.et al. 2016. A versatile disulfide-driven recycling system for NADP+ with high cofactor turnover number. ACS Catalysis 7, pp. 1025-1029. (10.1021/acscatal.6b03061) pdf Faraldos, J.et al. 2016. Enzymatic synthesis of natural (+)-aristolochene from a non-natural substrate. Chemical Communications 52(97), pp. 14027-14030. (10.1039/C6CC08164A) pdf Mart, R. and Allemann, R. 2016. Azobenzene photocontrol of peptides and proteins. Chemical Communications 52(83), pp. 12262-12277. (10.1039/C6CC04004G) pdf Gonzalez, V.et al. 2016. The amino-terminal segment in the β-domain of δ-cadinene synthase is essential for catalysis. Organic & Biomolecular Chemistry 14(31), pp. 7451-7454. (10.1039/C6OB01398H) pdf Ruiz-Pernía, J.et al. 2016. Minimization of dynamic effects in the evolution of dihydrofolate reductase. Chemical Science 7(5), pp. 3248-3255. (10.1039/C5SC04209G) pdf Chen, M.et al. 2016. Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. Biochemistry 55(20), pp. 2864-2874. (10.1021/acs.biochem.6b00343) doc Mart, R., Meah, D. and Allemann, R. K. 2016. Photocontrolled exposure of pro-apoptotic peptide sequences in LOV proteins modulate Bcl-2 family interactions. Chembiochem 17(8), pp. 698-701. (10.1002/cbic.201500469) pdf Grundy, D.et al. 2016. Mechanism of germacradien-4-ol synthase controlled water capture. Biochemistry 55(14), pp. 2112-2121. (10.1021/acs.biochem.6b00115) pdf Loveridge, E. J. and Allemann, R. K. 2016. Pinpointing dynamic coupling in enzymes for efficient drug design. Future Science OA 2(1) (10.4155/fsoa.2015.0017) pdf Adams, S.et al. 2015. Conformationally restricted calpain inhibitors. Chemical Science 6(12), pp. 6865-6871. (10.1039/c5sc01158b) pdf