White, Alex - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

Graduated from the University of Newcastle upon Tyne and awarded a PhD in anti-cancer drug design from the same University. Held a faculty research position at the Arizona State University Cancer Research Institute under Professor Bob Pettit studying the anti-cancer constituents of marine organisms. Returned to the UK as a research associate at the Northern Institute of Cancer Research (1998-2000) and joined the staff of the School of Pharmacy and Pharmaceutical Sciences in 2000.

研究领域

Major interests concern the design and synthesis of novel anti-cancer agents. This involves synthetic organic chemistry, molecular modelling, purification methods and spectroscopy, particularly high field NMR, and close collaboration with biochemists. Particularly of interest is the development of natural product lead compounds as clinically useful chemotherapeutic agents.

近期论文

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Lau, W. M., Heard, C. M. and White, A. W. 2013. Design, synthesis and in vitro degradation of a novel co-drug for the treatment of psoriasis. Pharmaceutics 5(2), pp. 232-245. (10.3390/pharmaceutics5020232) White, A.et al. 2012. Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine. European Journal of Medicinal Chemistry 56, pp. 246-253. (10.1016/j.ejmech.2012.08.022) Lau, W.et al. 2011. Therapeutic and cytotoxic effects of the novel antipsoriasis codrug, naproxyl-dithranol, on HaCaT cells. Molecular Pharmaceutics 8(6), pp. 2398-2407. (10.1021/mp200327k) Lau, W.et al. 2010. Histochemical visualisation of esterase activity in porcine ear skin. Pharmacy and Pharmacology 62(6), pp. 798-798. (10.1211/jpp.62.06.0016) Lau, W. M., White, A. W. and Heard, C. M. 2010. Topical delivery of a naproxen-dithranol co-drug: in vitro skin penetration, permeation, and staining. Pharmaceutical Research 27(12), pp. 2734-2742. (10.1007/s11095-010-0274-8) Lau, W.et al. 2008. Scope and limitations of the co-drug approach to topical drug delivery. Current Pharmaceutical Design 14(8), pp. 794-802. White, A. W., Westwell, A. and Brahemi, G. 2008. Protein-protein interactions as targets for small-molecule therapeutics in cancer. Expert Reviews in Molecular Medicine 10(e8), pp. 1-14. (10.1017/S1462399408000641) pdf White, A.et al. 2004. Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors. Biorganic and Medicinal Chemistry Letters 14(10), pp. 2433-2437. (10.1016/j.bmcl.2004.03.017) Perdomo-Lopez, I.et al. 2002. Effect of cyclodextrins on the solubility and antimycotic activity of sertaconazole: Experimental and computational studies. Journal of Pharmaceutical Sciences 91(11), pp. 2408-2415. (10.1002/jps.10237) White, A.et al. 2000. Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase. Journal of Medicinal Chemistry 43(22), pp. 4084-4097. (10.1021/jm000950v)