Westwell, Andrew D. - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

I graduated with a degree in Chemistry from the University of Leeds in 1990, and then completed a PhD in synthetic organic chemistry from the same department under the supervision of Professor Chris Rayner. Following a two-year postdoctoral position in the Department of Chemistry at Loughborough University under the supervision of Professor Jonathan Williams then Professor Chris Moody, I was appointed as a Research Fellow within the Cancer Research Laboratories at the University of Nottingham, with Professor Malcolm Stevens. I was appointed to a Cancer Research UK funded Lectureship in 2001 in the School of Pharmacy at Nottingham, and moved to the School of Pharmacy and Pharmaceutical Science in 2006 to take up a position as Senior Lecturer in Medicinal Chemistry. I was promoted to Reader in 2013.

研究领域

Having trained in synthetic organic chemistry, focusing on asymmetric synthesis and catalysis, the main focus of my research activities in recent years has been in the area of medicinal chemistry and cancer drug discovery. I am a medicinal chemist with extensive experience of the synthesis and biological evaluation of new small molecules with potential antitumour activity. My research interests can be divided into the following categories: Breast cancer drug design and discovery Selective apoptosis induction in cancer cells Protein-protein interactions as cancer drug targets E3 ubiquitin ligases as therapeutic targets in cancer Diagnostic imaging (Positron Emission Tomography) in oncology and neuroscience Characterisation of novel psychoactive substances, in conjunction with Public Heath Wales and Llandough Hospital Cardiff

近期论文

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Hamdy, R.et al. 2017. Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents. Bioorganic & Medicinal Chemistry Letters 27(4), pp. 1037-1040. (10.1016/j.bmcl.2016.12.061) Ziedan, N.et al. 2017. Virtual screening, SAR and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor. Chemical Biology and Drug Design (10.1111/cbdd.12936) pdf Wymant, J.et al. 2016. The Role of BCA2 in the endocytic trafficking of EGFR and significance as a prognostic biomarker in cancer. Journal of Cancer 7(15), pp. 2388-2407. (10.7150/jca.15055) pdf Kandil, S.et al. 2016. ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites. Biorganic and Medicinal Chemistry Letters 26(23), pp. 5618-5623. (10.1016/j.bmcl.2016.10.077) pdf Bassetto, M.et al. 2016. Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry 118, pp. 230-243. (10.1016/j.ejmech.2016.04.052) pdf Ferla, S.et al. 2016. Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic & Medicinal Chemistry Letters 26(15), pp. 3636-3640. (10.1016/j.bmcl.2016.06.001) pdf Kothayer, H.et al. 2016. Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors. Biorganic and Medicinal Chemistry Letters 26(8), pp. 2030-2034. (10.1016/j.bmcl.2016.02.085) pdf Haynes, B.et al. 2016. Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization. Nanomedicine: Nanotechnology, Biology and Medicine 12(3), pp. 745-757. (10.1016/j.nano.2015.10.010) pdf Kandil, S.et al. 2016. Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. European Journal of Medicinal Chemistry 110, pp. 311-325. (10.1016/j.ejmech.2015.12.037) pdf Shirinzadeh, H.et al. 2016. Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities. Journal of Enzyme Inhibition and Medicinal Chemistry (10.3109/14756366.2015.1132209) pdf