Sumerlin, Brent S. - University of Florida

个人简介

2017- George Bergen Butler Professor Department of Chemistry University of Florida 2015-2017 Professor Department of Chemistry University of Florida 2012-2015 Associate Professor Department of Chemistry University of Florida 2009-2012 Harold Jeskey Trustee Associate Professor in Chemistry Department of Chemistry Southern Methodist University 2007-2009 Harold Jeskey Trustee Assistant Professor in Chemistry Department of Chemistry Southern Methodist University 2005-2007 Assistant Professor Department of Chemistry Southern Methodist University 2003-2005 Visiting Assistant Professor Advisor: Krzysztof Matyjaszewski Department of Chemistry Carnegie Mellon University 2003 Ph.D. Polymer Science & Engineering Advisor: Charles L. McCormick Department of Polymer Science University of Southern Mississippi 1998 B.S., Textile Chemistry, Polymer Chemistry Concentration North Carolina State University

研究领域

Our research concerns the identification, synthesis, and characterization of polymers with selected functionality, composition, and molecular architecture. Several areas of polymer chemistry are being investigated, with particular focus on those most closely related to biological applications. Functional polymer synthesis and efficient polymer modification via specific and orthogonal methodologies. A significant effort is dedicated to devising new synthetic routes to functional macromolecules. In addition to relying on living/controlled radical polymerization techniques to prepare polymers of controlled molecular weight and retained end group functionality, highly efficient postpolymerization modification is required to incorporate functionality not easily included in monomer, initiator, or chain transfer agents. Many chemical transformations employed in organic synthesis do not demonstrate the same degree of efficiency and orthogonality when used for functionalization of high molecular weight macromolecules. Therefore, a significant effort in our group has involved the extension of "click chemistry" methodologies for functional polymer synthesis. Stimuli-responsive water-soluble block copolymers. The solution behavior of polymers that exhibit "smart" behavior in aqueous media is being investigated. Responsive block copolymers can be induced to form micelles, vesicles, or gels, and may ultimately lead to new applications in controlled drug delivery, tissue engineering, and surface biocompatibilization. Dynamic-covalent macromolecular materials. By constructing macromolecular assemblies with linkages that are reversibly covalent, we prepare new materials with the ability to adapt their structure, constitution, and reactivity depending on the nature of the surrounding environment. Reversibility being a key attribute, these systems offer versatility typically associated with supramolecular materials (dynamic rearrangement, self-assembly, self-repair, etc.), while maintaining the integrity and robust nature of covalently formed polymers. Materials constructed via covalent bonds that can be triggered to dissociate in response to specific chemical stimuli include smart nanoparticles, organogels, and self-healing coatings. Smart polymer-protein bioconjugates. Modifying biological molecules with "smart" polymers provides a means to externally control the solubility and activity of proteins, peptides, and nucleic acids. Examples of such hybrid materials include polymer-protein conjugates in which the activity, stability, or solubility of the protein can be tuned by capitalizing on the responsive nature of the immobilized synthetic polymer.

近期论文

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Christopher P. Kabb, Christopher S. O’Bryan, Christopher C. Deng, Thomas E. Angelini, and Brent S. Sumerlin “Photoreversible Covalent Hydrogels for Soft-Matter Additive Manufacturing” ACS Applied Materials & Interfaces 2018, 10, 16793-16801. Mollie A. Touve, C. Adrian Figg, Daniel B. Wright, Chiwoo Park, Joshua Cantlon, Brent S. Sumerlin, Nathan C. Gianneschi “Polymerization-Induced Self-Assembly of Micelles Observed by Liquid Cell Transmission Electron Microscopy” ACS Central Science 2018, DOI: 10.1021/acscentsci.8b00148. Jessica J. Cash, Tomohiro Kubo, Daniel J. Dobbins, Brent S. Sumerlin “Maximizing the symbiosis of static and dynamic bonds in self-healing boronic ester networks” Polymer Chemistry 2018, 9, 2011-2020. Tapomoy Bhattacharjee, Christopher P. Kabb, Christopher S. O’Bryan, Juan M. Urueña, Brent S. Sumerlin, W. Gregory Sawyer and Thomas E. Angelini “Polyelectrolyte scaling laws for microgel yielding near jamming” Soft Matter 2018, 14, 1559-1570. C. Adrian Figg, James D. Hickman, Georg M. Scheutz, Sivaprakash Shanmugam, R. Nicholas Carmean, Bryan S. Tucker, Cyrille Boyer , and Brent S. Sumerlin “Color-Coding Visible Light Polymerizations To Elucidate the Activation of Trithiocarbonates Using Eosin Y” Macromolecules 2018, 51, 1370-1376. Michael B. Sims, Kush Y. Patel, Mallika Bhatta, Soma Mukherjee, and Brent S. Sumerlin “Harnessing imine diversity to tune polymer degradation” Macromolecules 2018, 51, 356-363. Cary A. Kuliasha, Rebecca L. Fedderwitz, Patricia R. Calvo, Brent S. Sumerlin, and Anthony B. Brennan “Engineering the Surface Properties of Poly(dimethylsiloxane) Utilizing Aqueous RAFT Photografting of Acrylate/Methacrylate Monomers” Macromolecules 2018, 51, 306-317. Soma Mukhejee, Jessica, J. Cash, Brent S. Sumerlin “Responsive and Dynamic Covalent Polymers” in Dynamic Covalent Chemistry: Principles, Reactions, and Applications; Zhang, W.; Jin, Y., Eds.;Wiley, Hoboken, NJ, 2018, pp 321-349. Tomohiro Kubo, Kyle C. Bentz, Kristin C. Powell, C. Adrian Figg, Jeremy L. Swartz, Maxym Tansky, Anuj Chauhan, Daniel A. Savina and Brent S. Sumerlin “Modular and rapid access to amphiphilic homopolymers via successive chemoselective post-polymerization modification” Polymer Chemistry 2017, 8, 6028-6032. Charles P. Easterling, Tomohiro Kubo, Zachary M. Orr, Gail E. Fanucci and Brent S. Sumerlin “Synthetic upcycling of polyacrylates through organocatalyzed post-polymerization modification” Chemical Science 2017, 8, 7705-7709. Megan R. Hill, Elise Guégain, Johanna Tran, C. Adrian Figg, Andrew C. Turner†, Julien Nicolas, and Brent S. Sumerlin “Radical Ring-Opening Copolymerization of Cyclic Ketene Acetals and Maleimides Affords Homogeneous Incorporation of Degradable Units” ACS Macro Letters 2017, 6, 1071-1077. Thomas E. Gartner III, Tomohiro Kubo, Youngmi Seo, Maxym Tansky, Lisa M. Hall, Brent S. Sumerlin, and Thomas H. Epps III “Domain Spacing and Composition Profile Behavior in Salt-Doped Cyclic vs Linear Block Polymer Thin Films: A Joint Experimental and Simulation Study” Macromolecules 2017, 51, 7169–7176. Eva Blasco, Michael B. Sims, Anja S. Goldmann, Brent S. Sumerlin, and Christopher Barner-Kowollik “50th Anniversary Perspective: Polymer Functionalization” Macromolecules 2017, 50, 5215-5252. Yuan Liu, Weijia Hou, Hao Sun, Cheng Cui, Liqin Zhang, Ying Jiang, Yongxiang Wu, Yanyue Wang, Juan Li, Brent S. Sumerlin, Qiaoling Liu and Weihong Tan “Thiol–ene click chemistry: a biocompatible way for orthogonal bioconjugation of colloidal nanoparticles” Chemical Science 2017, 8, 6182-6187. William L. A. Brooks, Gertjan Vancoillie, Christopher P. Kabb, Richard Hoogenboom, Brent S. Sumerlin “Triply-Responsive Block Copolymers Combining pH-Responsive, Thermoresponsive, and Glucose-Responsive Behaviors” Journal of Polymer Science, Part A: Polymer Chemistry 2017, 55, 2309-2317. Christopher S. O’Bryan, Tapomoy Bhattacharjee, Samuel Hart, Christopher P. Kabb, Kyle D. Schulze, Indrasena Chilakala, Brent S. Sumerlin, W. Gregory Sawyer, and Thomas E. Angelini “Self-assembled micro-organogels for 3D printing silicone structures” Science Advances 2017, 10.1126/sciadv.1602800. Bryan S. Tucker, McKenzie L. Coughlin, C. Adrian Figg, and Brent S. Sumerlin “Grafting-From Proteins Using Metal-Free PET–RAFT Polymerizations under Mild Visible-Light Irradiation” ACS Macro Letters 2017, 6, 452-457. Xiao Wang, C. Adrian Figg, Xiaoqing Lv, Yongqi Yang, Brent S. Sumerlin, and Zesheng An “Star Architecture Promoting Morphological Transitions during Polymerization-Induced Self-Assembly” ACS Macro Letters 2017, 6, 337-342. C. Adrian Figg, Ashton N. Bartley, Tomohiro Kubo, Bryan S. Tucker, Ronald K. Castellano and Brent S. Sumerlin “Mild and efficient synthesis of ω,ω-heterodifunctionalized polymers and polymer bioconjugates” Polymer Chemistry 2017, 8, 2457-2461. Hao Sun, Christopher P. Kabb, Yuqiong Dai, Megan R. Hill, Ion Ghiviriga, Abhijeet P. Bapat and Brent S. Sumerlin “Macromolecular metamorphosis via stimulus-induced transformations of polymer architecture” Nature Chemistry 2017, 9, 817-823.