Thomas, Chris - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

I completed my degree in Chemistry with Industrial Experience in 2002 from Cardiff University before moving to the School of Pharmacy to undertake a PhD in transdermal delivery. Following this I completed a postdoctoral position in Cardiff University School of Medicine before being awarded a Marie Curie Fellowship in 2010 to study at Vanderbilt University School of Medicine, Nashville, TN. In 2013 I was awarded a NISHCR/Wellcome Trust fellowship before acting as co-investigator and Research Fellow on an MRC Research Award. I started my current position as Lecturer in the School of Pharmacy and Pharmaceutical Sciences in Nov 2016.

研究领域

Chris's research is focused on the role of oxidised lipids in health and disease. Recent advances in analytical techniques have significantly expanded the knowledge on lipids and they are no longer considered as merely cell membrane constituents. They can now be considered as bioactive mediators involved in a range of cellular and physiological processes from blood clotting and immune cell response to maintaining our skins barrier function. Chris is currently focused on the role of these lipids in wound healing and skin disease, with particular interest in the crosstalk between skin cells and bacteria that make up the skins microbiome. In collaboration with other members of the School of Pharmacy and Pharmaceutical Sciences, Chris is developing novel skin models using 3D printing to study skin disease and the immunological control of skin cancer progression.

近期论文

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Chiba, T.et al. 2016. The precise structures and stereochemistry of trihydroxy-linoleates esterified in human and porcine epidermis and their significance in skin barrier function: Implication of an epoxide hydrolase in the transformations of linoleate. Journal of Biological Chemistry 291(28), pp. 14540-14544. (10.1074/jbc.M115.711267) pdf Hinz, C.et al. 2016. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological Chemistry 291(26), pp. 13448-13464. (10.1074/jbc.M115.700609) pdf McCully, M.et al. 2015. Skin metabolites define a new paradigm in the localization of skin tropic memory T cells. The Journal of Immunology 195(1), pp. 96-104. (10.4049/jimmunol.1402961) pdf Morgan, A.et al. 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4, pp. 40-47. (10.1016/j.redox.2014.11.005) pdf Thomas, C.et al. 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9(1), pp. 51-63., article number: 1754-2189. (10.1038/nprot.2013.163) pdf Muñoz-Garcia, A.et al. 2014. The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841(3), pp. 401-408. (10.1016/j.bbalip.2013.08.020) pdf Clark, S.et al. 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110(15), pp. 5875-5880. (10.1073/pnas.1222419110) Moideen, A.et al. 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52(s1), pp. 138-139. Hammond, V.et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287(50), pp. 41651-41666. (10.1074/jbc.M112.405407)