Taylor, Kathryn - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

Kathryn Taylor began her post-doctoral career in the field of kidney preservation for transplantation at the department of surgery in Kings' College Hospital, Denmark Hill, London. After a 9 year maternal career break she returned to investigate the role of complement component C9 in arthritis at the department of Medical Biochemistry, Heath Hospital, Cardiff. Kathryn joined the Tenovus centre for cancer research in 1997 where she has been investigating the role of the LIV-1 family of zinc transporters in breast cancer.

研究领域

The mechanism of action of zinc transporters The regulation of intracellular zinc homeostasis The role of zinc transporters in cell migration The role of zinc and zinc transporters in breast cancer progression I am especially interested in investigating the mechanism of action of cellular zinc transporters, especially the ZIP family (also known as SLC39A). The intention is to substantiate a model for integrated zinc signalling in cells, confirming the key role of zinc transporters, especially ZIP7, and relating the findings to the fundamental biological effects of cellular zinc. These zinc signalling events are thought to be primarily controlled by specific zinc transporters and my recent novel finding that their zinc transport ability can be controlled by phosphorylation, a mechanism previously unprecedented for zinc transporters, will be examined for a direct structural and/or functional relationship with cellular signalling pathways. These events lead to diverse cellular effects on normal processes such as growth, development and migration or, when aberrantly regulated, diseases such as cancer, diabetes and neurodegeneration ensuring that this project has widespread application for normal and disease states. The primary focus of my research is to understand how zinc transporters work in cells to control intracellular zinc homeostasis. I am especially interested in the 9 human members of the LIV-1 family of zinc transporters and their role in the progression of breast cancer. These studies include the effects of zinc on multiple signalling pathways as well as growth and invasion, all elements known to lead to cancer progression.

近期论文

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Nimmanon, T.et al. 2017. Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling. Metallomics (10.1039/C6MT00286B) Taylor, K.et al. 2016. Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration. Biochemical Journal 473, pp. 2531-2544. (10.1042/BCJ20160388) pdf Hessels, A. M., Taylor, K. M. and Merkx, M. 2016. Monitoring cytosolic and ER Zn2+ in stimulated breast cancer cells using genetically encoded FRET sensors. Metallomics 8, pp. 211-217. (10.1039/C5MT00257E) pdf Liu, Y.et al. 2015. Characterization of Zinc Influx Transporters (ZIPs) in pancreatic beta cells: roles in regulating cytosolic zinc homeostasis and insulin secretion. Journal of Biological Chemistry 290, pp. 18757-18769., article number: jbc.M115.640524. (10.1074/jbc.M115.640524) pdf Hessels, A.et al. 2015. eZinCh-2: a versatile, genetically encoded FRET sensor for cytosolic and intraorganelle Zn2+Imaging. ACS Chemical Biology 10(9), pp. 2126-2134., article number: 150720121509007. (10.1021/acschembio.5b00211) pdf Wiggins, H.et al. 2015. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochemical Pharmacology 93(3), pp. 332-342. (10.1016/j.bcp.2014.12.014) pdf Hogstrand, C.et al. 2013. A mechanism for epithelial–mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3). Biochemical Journal 455(2), pp. 229-237. (10.1042/BJ20130483) pdf Taylor, K. M., Kille, P. and Hogstrand, C. 2012. Protein kinase CK2 opens the gate for zinc signaling. Cell Cycle 11(10), pp. 1863-1864. (10.4161/cc.20414) pdf Taylor, K.et al. 2012. Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. Science Signaling 5(210), article number: ra11. (10.1126/scisignal.2002585) pdf Taylor, K.et al. 2011. Differential subcellular localization of the splice variants of the zinc transporter ZnT5 is dictated by the different C-terminal regions. PLoS ONE 6(8), article number: e23878. (10.1371/journal.pone.0023878) pdf