Simons, Claire - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

I graduated with a BSc (Hons) degree in Chemistry from Kings College London in 1989 and continued at Kings to undertake a PhD in the laboratories of Professor Colin B. Reese on "Studies in the synthesis of ribonucleoside and oligonucleotide analogues". On completion of my PhD in 1992 I obtained a NIH exchange fellowship and worked at the Michigan Cancer Foundation (now the Karmanos Cancer Institute), Detroit, USA on the synthesis of antiviral allenic derived nucleic acids under the supervision of Dr Jiri Zemlicka. In 1994 I returned to Europe to take up a postdoctoral position at the Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, Paris to work on the Taxol project under the supervision of Dr Francoise Kuong-Huu and a postdoctoral position at the University of Leicester in the laboratories of Dr Paul Jenkins involving studies towards the total synthesis of Taxol. I joined the School of Pharmacy and Pharmaceutical Sciences as a lecturer in 1995 and currently hold the position of Senior Lecturer.

研究领域

There are three main areas of research within my group at the School of Pharmacy and Pharmaceutical Sciences: Cellular differentiation and proliferation - targeting specific enzymes (CYP24 and CYP26) and receptors (PPAR) directed towards the development of therapeutics for the treatment of diseases associated with hyperproliferation e.g. cancers (hormone refractive prostate cancer (HRPC) and neuroblastoma (NBL)) and psoriasis, and as tools for investigating the underlying molecular biology associated with hyperproliferation and neurogenesis. Steroidogenesis - targeting enzymes associated with oestrogen production (primarily CYP19/aromatase) for the development of therapeutic agents for the treatment of hromone dependent breast cancer. Other enzyme targets of interest are 17b-hydroxysteroid dehydrogenase (17b-HSD) and oestrone sulfatase. Antiinfectives - covering antibacterial (including antimycobacterial) and antiviral agents. Targets include PgP efflux, InhA and P450 enzymes (antibacterial), reverse transcriptase (RT) and DNA polymerase (antiviral - nucleoside mimetics). Research in my group is multidisciplinary and concerns design, employing computational methods and a range of software, synthesis and in vitro biological evaluation (in-house: CYP19, CYP24, CYP26, 17b-HSD; external collaborations: PPAR, oestrone sulfatase, antiviral and antimycobacterial assays).

近期论文

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Eissa, A.et al. 2016. Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficileof novel 3-biaryl-N-benzylpropan-1-amine derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry (10.3109/14756366.2016.1140754) pdf Abd El-wahab, H.et al. 2016. Mycobacterial CYP121 as a target for anti-TB drug discovery. Der Pharma Chemica 8(6), pp. 178-188. pdf Stoney, P.et al. 2015. Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis. Brain Structure and Function , pp. 1-12. (10.1007/s00429-015-1102-z) pdf Ferla, S.et al. 2014. Small-molecule inhibitors of 25-Hydroxyvitamin D-24-Hydroxylase (CYP24A1): synthesis and biological evaluation. Journal of Medicinal Chemistry 57(18), pp. 7702-7715. (10.1021/jm5009314) pdf Ferla, S.et al. 2014. Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation. European Journal of Medicinal Chemistry 87, pp. 39-51. (10.1016/j.ejmech.2014.09.035) pdf Gomaa, M.et al. 2012. Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates. Bioorganic & Medicinal Chemistry 20(20), pp. 6080-6088. (10.1016/j.bmc.2012.08.044) Gomaa, M.et al. 2012. Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold. Bioorganic & Medicinal Chemistry 20(14), pp. 4201-4207. (10.1016/j.bmc.2012.05.076) Linley, E.et al. 2012. Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action. Journal of Antimicrobial Chemotherapy 67(7), pp. 1589-1596. (10.1093/jac/dks129) Linley, E.et al. 2012. Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action. Journal of Antimicrobial Chemotherapy 67(7), pp. 1589-1596. (10.1093/jac/dks129)