Prokopovich, Polina - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

2016-onwards: Senior Lecturer in Nanotechnology and Advanced Biomaterials, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, UK. 2014- 2016: Lecturer in Biomaterials, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, UK. 2011 - 2014: Cardiff Academic Fellow, School of Pharmacy and Pharmaceutical Sciences and School of Engineering. Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University, UK. 2010 - 2011: Research Fellow, Institute of Medical and Biological Engineering, Leeds University, UK. 2008 – 2010: Research Associate sponsored by Astra Zeneca, Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, UK 2007: Scientist, 3M Health Care Ltd, UK. 2003 - 2006 PhD, Chemical Engineering Department, Loughborough University, UK. 2000 - 2002 MSc, Physical, Colloid and Surface Science, St Petersburg State University, Russia. 1997 - 2000 BSc, Chemistry Department, St Petersburg State University, Russia.

研究领域

Targeted drug delivery for joint diseases The goal is to achieve Higher drug uptake and Higher retention in the tissue with ability to target disease pathology and to avoids off-target organ toxicity (side effects). Anti-inflammatory Drug delivery systems to prevent wear particles-induced inflammation The aim is to prepare anti-inflammatory drug eluting implant model to target inflammation. Orthopaedic antimicrobial nanocomposite bone cements Our approach is to fabricate metal and organic NPs with antimicrobial activity and encapsulate them into bone cement formulation producing nanocomposite materials with functional properties. Multifunctional hydrogels as bone graft materials Our approach is to use nanotechnology and polymer chemistry to prepare novel nanocomposite hydrogels with multiple functionality (osseoinductive, osseoconductive and antimicrobial properties). Nanomechanical and surface properties of cells post exposure to metal, ceramic and polymeric wear particles Our aim is to achieve a greater depth of knowledge into the adhesive interactions and nanomechanical aspects of cells surrounding implantations which have not been investigated previously, and will require research into adhesion concepts adaptable to biological systems. Considerations for the influence of surface parameters and surface treatments along with their impact on cells nanomechanical and adhesive properties caused by implant debris are investigated.

近期论文

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Perni, S. and Prokopovich, P. 2017. Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage. Nanomedicine: Nanotechnology, Biology and Medicine 13(2), pp. 539-548. (10.1016/j.nano.2016.10.001) pdf Sataev, M.et al. 2016. A low-temperature gold coating of the dielectric surfaces employing phosphine gas as a reducing agent. Colloids and Surfaces A: Physicochemical and Engineering Aspects (10.1016/j.colsurfa.2016.11.029) pdf Giacomo, T., Perni, S. and Prokopovich, P. 2016. An injectable hydrogel as bone graft material with added antimicrobial properties. Tissue Engineering Part A 22(11-12), pp. 862-872. (10.1089/ten.tea.2016.0014) pdf Perni, S. and Prokopovich, P. 2016. Lethal photosensitisation of bacteria using Silica-TBO nanoconjugates. Colloids and Surfaces A: Physicochemical and Engineering Aspects pdf Perni, S.et al. 2016. Influence of csgD and ompR on nanomechanics, adhesion forces and curli properties of E. coli. Langmuir 32(31), pp. 7965-7974. (10.1021/acs.langmuir.6b02342) pdf Perni, S.et al. 2015. Antimicrobial activity of bone cements embedded with organic nanoparticles. International Journal of Nanomedicine 10, pp. 6317-6329. pdf Preedy, E. C., Perni, S. and Prokopovich, P. 2015. Cobalt, titanium and PMMA bone cement debris influence on mouse osteoblast cell elasticity, spring constant and calcium production activity. RSC Advances 5, pp. 83885-83898. (10.1039/C5RA15390E) pdf Sataev, M.et al. 2015. A galvanic-chemical method for preparing diamond containing coatings. Colloids and Surfaces A: Physicochemical and Engineering Aspects 480, pp. 384-389. (10.1016/j.colsurfa.2014.09.014) pdf Gustaite, S.et al. 2015. Characterization of cellulose based sponges for wound dressings. Colloids and Surfaces A: Physicochemical and Engineering Aspects 480, pp. 336-342. (10.1016/j.colsurfa.2014.08.022) pdf Perni, S. and Prokopovich, P. 2015. Multi-asperity elliptical JKR model for adhesion of a surface with non-axially symmetric asperities. Tribology International 88, pp. 107-114. (10.1016/j.triboint.2015.03.001) pdf González-Sánchez, M.et al. 2015. Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications. Materials Science and Engineering C 50, pp. 332-340. (10.1016/j.msec.2015.02.002) pdf