个人简介
2015 – onwards Senior Lecturer in Pharmacology, School of Pharmacy and Pharmaceutical Sciences
2009-2015, Lecturer in Pharmacology, School of Pharmacy and Pharmaceutical Sciences
2006-2009, Post-Doctoral Research Associate, Brain Repair Centre, Department of Neuroscience, Cardiff University
Working with Prof Stephen Dunnett and Prof Anne Rosser I continued my work on L-dopa and post-transplantation dyskinesia contributing to two successful EU FP7 grant awards.
2004-2006, Post-Doctoral Research Associate, Units of Neuronal Survival and Basal Ganglia Pathophysiology, Lund University, Sweden.
I spent 2 years in Sweden with the groups of Prof Patrik Brundin and Prof Angela Cenci developing, characterizing and working with a model of post-transplantation dyskinesia
2000-2004, PhD, King's College London, UK
I had a BBSRC CASE award studentship with Prof Peter Jenner and Dr Sharon Cheetham (then Knoll Pharmaceuticals) on the potential of BTS 74398, a monoamine uptake inhibitor, as a possible anti-parkinsonian medication.
1996-2000, Pharmacology B.Sc. Honours 1st Class with industrial placement, University College London, UK.
Specialising in neuropharmacology options and spending an industrial year at Knoll Pharmaceuticals working on the pharmacology of the anti-obesity agent sibutramine.
研究领域
Member of the School's Medicines Optimisation and Health Outcomes and Experimental therapeutics and Pharmaceutical Sciences research disciplines.
近期论文
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Breger, L.et al. 2016. Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease. Brain, Behavior, and Immunity (10.1016/j.bbi.2016.11.014) pdf
Rylander Ottosson, D. and Lane, E. L. 2016. Striatal plasticity in L-DOPA- and graft-induced dyskinesia:the common link?. Frontiers in Cellular Neuroscience 10, article number: 16. (10.3389/fncel.2016.00016) pdf
Lindgren, H.et al. 2014. The effect of additional noradrenergic and serotonergic depletion on a lateralised choice reaction time task in rats with nigral 6-OHDA lesions. Experimental Neurology 253, pp. 52-62. (10.1016/j.expneurol.2013.11.015) pdf
Lane, E. L., Dunnett, S. B. and Fricker, R. A. 2013. The 12th meeting of the International Society for Neural Transplantation and Restoration. NeuroReport 24(18), pp. 997-999. (10.1097/WNR.0000000000000101)
Murphy, E.et al. 2013. Long-term restorative effects of bromocriptine on operant responding in the 6-hydroxydopamine-lesioned rat. NeuroReport 24(18), pp. 1019-1024. (10.1097/WNR.0000000000000060)
Lelos, M. J., Lane, E. and Dunnett, S. B. 2013. What helps can also hinder: A dissociation in the acute effect of levodopa treatment on motor and cognitive functions. Movement Disorders 28(5), pp. 563-564. (10.1002/mds.25294)
Breger, L. S., Dunnett, S. B. and Lane, E. L. 2013. Comparison of rating scales used to evaluate l-DOPA-induced dyskinesia in the 6-OHDA lesioned rat. Neurobiology of Disease 50, pp. 142-150. (10.1016/j.nbd.2012.10.013)
Klein, A., Lane, E. L. and Dunnett, S. B. 2013. Brain repair in a unilateral rat model of Huntington's Disease: new insights into impairment and restoration of forelimb movement patterns. Cell Transplantation 22(10), pp. 1735-1751. (10.3727/096368912X657918)
Smith, G.et al. 2012. Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats. Neuropharmacology 63(5), pp. 818-828. (10.1016/j.neuropharm.2012.06.011)