Kidd, Emma - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

I graduated with a degree in Pharmacology from the University of Bath in 1987 and then went to the Department of Physiology and Pharmacology at Nottingham University to do a Ph.D. on the "Functional Adaptation of 5-HT Receptors" under the supervision of Prof. Charles Marsden. Having graduated from Nottingham in 1990, I went to Paris to work for two years as a postdoctoral research associate in Dr Michel Hamon's INSERM-funded laboratory. In 1992 I returned to the U.K. to work as a Postdoctoral Research Associate and subsequently as a Senior Postdoctoral Research Associate for Prof. Pat Humphrey in the Glaxo Institute for Applied Pharmacology in the Department of Pharmacology at Cambridge University. In 1999, I joined the School of Pharmacy and Pharmaceutical Sciences at Cardiff University as a lecturer and was promoted to senior lecturer in 2009, and promoted again to Reader in 2013.

研究领域

I am interested in understanding how Alzheimer's disease develops and how it could be treated. Research in my laboratory is concentrated on cellular and molecular pharmacology to understand more about the mechanisms underlying several disease processes, with the ultimate aim of improving or developing new therapies for these conditions. We use a variety of human cell lines, animal models and human tissue and many biochemical and molecular biological techniques to investigate cell function. Ageing in the brain Alzheimer's disease Development of models of respiratory disease

近期论文

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Thomas, R.et al. 2016. Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease. BMC Neuroscience 17(50) (10.1186/s12868-016-0288-1) pdf Evans, R.et al. 2015. Pulmonary oedema measured by MRI correlates with late-phase response to allergen challenge. Experimental Lung Research 41(4), pp. 189-198. (10.3109/01902148.2014.985407) pdf Lowe, A.et al. 2015. Lipopolysaccharide exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea-pig model of asthma. British Journal of Pharmacology 172(10), pp. 2588-2603. (10.1111/bph.13080) pdf Yarova, P.et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282) pdf Lowe, A.et al. 2015. Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs. Journal of Pharmacological and Toxicological Methods 72, pp. 85-93. (10.1016/j.vascn.2014.10.007) pdf Thomas, R. S. and Kidd, E. J. 2014. Caveolin-1 alters the amyloidogenic processing of amyloid precursor protein to amyloid-beta. Neuroreport -Oxford- 25(3), pp. 162-162. (10.1097/01.wnr.0000443076.61006.22) pdf Kidd, E. J., Hvoslef-Eide, M. and Thomas, R. S. 2014. Anti-amyloid precursor protein antibodies as a potential therapy for Alzheimer's disease [Abstract]. Neuroreport 25(3), pp. 145-145. (10.1097/01.wnr.0000443076.61006.22) pdf Ford, W.et al. 2013. Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs. Clinical Science 125(10), pp. 471-482. (10.1042/CS20130130) Broadley, K.et al. 2013. Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines. European Journal of Pharmacology 715(1-3), pp. 370-380. (10.1016/j.ejphar.2013.04.034) Thomas, R.et al. 2013. Inhibition of amyloid-[beta] production by anti-amyloid precursor protein antibodies in primary mouse cortical neurones. NeuroReport 24(18), pp. 1058-1061. (10.1097/WNR.0000000000000055)