Jones, Arwyn Tomos - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

Arwyn gained his PhD in protein crystallography at Birkbeck College, University of London and undertook postdoctoral positions investigating membrane traffic on the endocytic pathway at the University of Liverpool and Harvard University. In 2000 he was awarded a European Molecular Biology Organization fellowship to work at the European Molecular Biology Laboratory (EMBL), Heidelberg Germany and continued at the EMBL via an Alexander von Humboldt Foundation Scholarship. In 2001 he was appointed as lecturer in the Cardiff School of Pharmacy and Pharmaceutical Sciences at Cardiff University where he is now Professor in Membrane Traffic and Drug Delivery. Research projects in his lab fall under themes of cancer cell biology, endocytosis and drug delivery. A major scientific objective is linking fundamental endocytosis research to better understand the cellular delivery of drug delivery vectors including antibodies targeting plasma membrane receptors and cell penetrating peptides. He actively collaborates with a number of national and international groups including his recent strong involvement with COMPACT, an academic/industrial drug delivery consortium collaborating on the Optimisation of Macromolecular Pharmaceutical Access to Cellular Targets. He has a keen interest in the public understanding of science and in 2001 was awarded a BBC sponsored Diploma in Journalism from Bangor University. Since then he has been very active in public engagement with science at local and national levels and has organised several large Science exhibitions at the National Eisteddfod of Wales.

研究领域

Research projects in my lab fall under themes of cell biology and endocytosis, concentrating on linking fundamental endocytosis research to the remit of cellular delivery of macromolecular therapeutics: Characterisation of endocytic pathways utilised by therapeutic macromolecules to gain access into cells Studying the mechanism of entry of cell penetrating peptides (CPP) and CPP-conjugates Designing new polymer -conjugates for cellular delivery of therapeutic macromolecule Utilising subcellular fractionation for analysis of endocytosis and intracellular traffic of therapeutic macromolecules. Characterising roles for endocytic pathways in mediating multidrug resistance in cancer cells Design and manufacture of microarray surfaces for multi-image analysis of biological specimens.

近期论文

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Hamdy, R.et al. 2017. Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents. Bioorganic & Medicinal Chemistry Letters 27(4), pp. 1037-1040. (10.1016/j.bmcl.2016.12.061) Ziedan, N.et al. 2017. Virtual screening, SAR and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor. Chemical Biology and Drug Design (10.1111/cbdd.12936) pdf Wymant, J.et al. 2016. The Role of BCA2 in the endocytic trafficking of EGFR and significance as a prognostic biomarker in cancer. Journal of Cancer 7(15), pp. 2388-2407. (10.7150/jca.15055) pdf Kandil, S.et al. 2016. Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. European Journal of Medicinal Chemistry 110, pp. 311-325. (10.1016/j.ejmech.2015.12.037) pdf Gurney, L.et al. 2016. Use of cell penetrating peptides to treat inflammatory responses in human uterine cells. Reproductive Sciences 23, pp. 292A-292A. (10.1177/1933719116641257) pdf Moody, P.et al. 2015. Receptor crosslinking – a general method to trigger internalisation and lysosomal targeting of therapeutic receptor:ligand complexes. Molecular Therapy 23(12), pp. 1888-1898. (10.1038/mt.2015.178) pdf Lemmer, Y.et al. 2015. Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis. Journal of Controlled Release 211, pp. 94-104. (10.1016/j.jconrel.2015.06.005) pdf Cilibrasi, V.et al. 2015. Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents. Tetrahedron Letters 56(20), pp. 2583-2585. (10.1016/j.tetlet.2015.03.132) pdf Pereira, P.et al. 2015. siRNA inhibition of endocytic pathways to characterize the cellular uptake mechanisms of folate functionalized glycol chitosan nanogels. Molecular Pharmaceutics 12(6), pp. 1970-1979., article number: 150416105321008. (10.1021/mp500785t) pdf Wiggins, H.et al. 2015. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochemical Pharmacology 93(3), pp. 332-342. (10.1016/j.bcp.2014.12.014) pdf