Ivory, Matthew - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

Career profile July 2016 - Present Lecturer, School of Pharmacy and Pharmaceutical Sciences, Cardiff University. September 2015 - October 2015 Visiting Researcher, Department of Immunology and Cell Biology, Osaka University, Japan. October 2012 - September 2016 Postgraduate Research Student, School of Pharmacy and Pharmaceutical Sciences, Cardiff University. Aug 2012 - Present Locum Pharmacist, various locations. Aug 2011 - Jul 2012 Pre-Registration Pharmacist, Bristol-Myers Squibb and St Helens and Knowsley Teaching Hospitals NHS Trust, Merseyside. September 2007 - July 2011 Undergraduate Student (MPharm), School of Pharmacy and Pharmaceutical Sciences, Cardiff University. Key Expertise Ex vivo human skin organ culture and histology (immunohistochemistry and immunofluorescence) Human skin immune cell extraction and culture Flow cytometry Pharmaceutical formulation

研究领域

Delivery of vaccines and therapeutics into the skin Human skin represents an ideal target for the delivery of therapeutics due to its accessibility and avoidance of first pass metabolism. In particular, the delivery of vaccines intradermally can take advantage of the diverse populations of immune cells present to allow for immunisation with reduced antigen doses compared to the practiced intramuscular injection route. The multiple subsets of human dermal dendritic cells and their roles in the uptake, processing and presentation of vaccine antigen to elicit immune responses alongside epidermal Langerhans cells are still under debate and so research in this area is vital to inform future vaccine design.

近期论文

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Czubala, M.et al. 2016. TGFβ induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial langerhans cells. Journal of Investigative Dermatology 136(10), pp. 1981-1989. (10.1016/j.jid.2016.05.123) pdf Caucheteux, S.et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136(6), pp. 1172-1181. (10.1016/j.jid.2016.01.033) pdf Ivory, M. O., Birchall, J. C. and Piguet, V. 2015. Early dengue virus infection in human skin: a cycle of inflammation and infectivity [Commentary]. Journal of Investigative Dermatology 135(7), pp. 1711-1712. (10.1038/jid.2014.544) pdf Pearton, M.et al. 2010. Changes in human Langerhans cells following intradermal injection of influenza virus-like particle vaccines. Plos One 5(8), article number: e12410. (10.1371/journal.pone.0012410) pdf Pearton, M.et al. 2010. Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin. Vaccine 28(37), pp. 6104-6113. (10.1016/j.vaccine.2010.05.055)