Heard, Charles - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

Career profile 2016 - present, Reader, Cardiff University 2007 – 2016, Senior Lecturer, Cardiff University Group leader, Skin and Natural Products group 1998 – 2007, Lecturer, Cardiff University 1991 – 1997, PDRA, Cardiff University 1987 – 1991, PhD student, Cardiff University 1982 – 1987, Team leader, Amersham International Scientific and professional service Membership of: The Academy of Pharmaceutical Sciences, International Society for Skin Pharmacology and Physiology

研究领域

Topical and transdermal drug delivery, development of in vitro models, pro-drugs & co-drugs, topical formulation design (e.g. cream, gel, drug-in-glue patches, medicated dressings), natural products, chemical analysis. Also: Targeted dermal/dermatological delivery Development of novel transcutaneous and transdermal delivery systems. Rational design of pro-drugs/co-drugs Probing mechanisms of topical drug delivery Natural products (particularly anti-inflammatory and anti-infectives)

近期论文

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Houston, D.et al. 2017. Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin. European Journal of Pharmaceutics and Biopharmaceutics 112, pp. 30-37. (10.1016/j.ejpb.2016.11.014) pdf Houston, D.et al. 2017. In vitro permeation and biological activity of punicalagin and zinc (II) across skin and mucous membranes prone to Herpes simplex virus infection. European Journal of Pharmaceutical Sciences 96, pp. 99-106. (10.1016/j.ejps.2016.08.013) pdf Chan, W.et al. 2016. Topical delivery of a Rho-kinase inhibitor to the cornea via Mucoadhesive film. European Journal of Pharmaceutical Sciences 91, pp. 256-264. (10.1016/j.ejps.2016.05.016) pdf Zulfakar, M. H., Porter, R. and Heard, C. 2016. In vivoresponse of GsdmA3Dfl/+ mice to topically applied fish oil - effects on cellular markers and macrophages. FEBS Open Bio 6(8), pp. 827-834. (10.1002/2211-5463.12095) pdf Abu Samah, N. H. and Heard, C. M. 2014. The effects of topically applied polyNIPAM-based nanogels and their monomers on skin cyclooxygenase expression,ex vivo. Nanotoxicology 8(1), pp. 100-106. (10.3109/17435390.2012.754511) pdf Lau, W. M., Heard, C. M. and White, A. W. 2013. Design, synthesis and in vitro degradation of a novel co-drug for the treatment of psoriasis. Pharmaceutics 5(2), pp. 232-245. (10.3390/pharmaceutics5020232) Abu Samah, N. H. and Heard, C. M. 2013. Enhanced in vitro transdermal delivery of caffeine using a temperature- and pH-sensitive nanogel, poly(NIPAM-co-AAc). International Journal of Pharmaceutics 453(2), pp. 630-640. (10.1016/j.ijpharm.2013.05.042) Lau, W.et al. 2012. Distribution of esterase activity in porcine ear skin, and the effects of freezing and heat separation. International Journal of Pharmaceutics 433(1-2), pp. 10-15. (10.1016/j.ijpharm.2012.04.079) Zulfakar, M. H., Ong, C. M. and Heard, C. M. 2012. The effects of betamethasone dipropionate and fish oil on HaCaT proliferation and apoptosis. International Journal of Pharmaceutics 434(1-2), pp. 399-405. (10.1016/j.ijpharm.2012.06.008) Wallace, E., Ong, C. M. Y. and Heard, C. M. 2012. Delivery of atovaquone and proguanil across sublingual membranes, in vitro. Pharmaceutical Development and Technology 17(6), pp. 770-776. (10.3109/10837450.2011.580760)