Gumbleton, Mark - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

Currently Executive Editor for Advanced Drug Delivery Reviews, a journal publishing high quality thematic reviews on a wide range of Advanced Drug Delivery topics. Also on the editorial board of the Journal of Drug Targeting and International Journal of Nanomedicine. I have published over: 90 full-length peer reviewed research publications 20 journal series, authored textbook chapters or edited books 116 conference abstracts or editorials. I have supervised 25 successful PhD students and 24 postdoctoral/visiting scientists. I have served on a number of pan-European scientific steering committees in drug delivery and as organiser/ scientific programme organiser for International scientific meetings. I also serve as a consultant to pharmaceutical industry in USA and UK and is Director of Research at the School of Pharmacy and Pharmaceutical Sciences, Cardiff University.

研究领域

Hypothesis-driven science surrounding issues at the interface between the nature of biological barriers and experimental therapeutics. The laboratory maintains a wide range of techniques ranging from cell and molecular biology through to ex-vivo and in-vivo models to address the scientific issues. There are two principle areas within the laboratory's research strategy: blood-brain-barrier and in the developing area of brain tumour research.

近期论文

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Paul, G. R., Gumbleton, M. and Somers,, G. I. 2017. Effect of conditioning on rat lung function measurements and implications for exposure and dose estimation of inhaled drugs. Inhalation Campbell, L.et al. 2016. Phospho-4e-BP1 and eIF4E overexpression synergistically drives disease progression in clinically confined clear cell renal cell carcinoma. American Journal of Cancer Research 5(9), pp. 2838-2848. pdf Williams, N.et al. 2016. Evidence of nonuniformity in urothelium barrier function between the upper urinary tract and the bladder. The Journal of Urology 195(3), pp. 763-770. (10.1016/j.juro.2015.10.066) pdf Ulaeto, D.et al. 2016. Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets. Antimicrobial Agents and Chemotherapy , article number: AAC.02146-15. (10.1128/AAC.02146-15) pdf Rohrer, J.et al. 2016. Mucus permeating thiolated self-emulsifying drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics 98, pp. 90-97. (10.1016/j.ejpb.2015.11.004) pdf Aljayyoussi, G.et al. 2015. Absorption of ipratropium and L-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters. International Journal of Pharmaceutics 496(2), pp. 834-841. (10.1016/j.ijpharm.2015.10.036) pdf Albaldawi, M.et al. 2015. Nanoparticle diffusion within intestinal mucus: Three-dimensional response analysis dissecting the impact of particle surface charge, size and heterogeneity across polyelectrolyte, pegylated and viral particles. European Journal of Pharmaceutics and Biopharmaceutics 97(Part A), pp. 230-238. (10.1016/j.ejpb.2015.01.023) pdf Grießinger, J.et al. 2015. Methods to determine the interactions of micro- and nanoparticles with mucus. European Journal of Pharmaceutics and Biopharmaceutics 96, pp. 464-476. (10.1016/j.ejpb.2015.01.005) pdf