Ford, William - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

2002 - Cardiff University (Cardiff, UK) Lecturer in the Welsh School of Pharmacy. (promoted to Senior Lecturer in 2010) 1998-2002 - University of Cambridge (Cambridge, UK) Department of Pharmacology Fellowship. Five year appointment with departmental operating grant (£72,000 over 5 years). Salary: £24,227 1996-1998 - University of Alberta (Edmonton, Canada): Postdoctoral fellowship with Dr BI Jugdutt researching the pharmacology of angiotensin II in post-myocardial infarction remodeling, ischaemia-reperfusion injury and myocardial energy substrate metabolism. 1994-96 - University of Alberta (Edmonton, Canada): Ciba-Giegy postdoctoral fellowship with Dr AS Clanachan, Dr R Schulz and Dr GD Lopaschuk. Researched adenosine A1 receptor and KATP-channel pharmacology in cardioprotection from ischaemia-reperfusion injury and myocardial energy substrate metabolism.

研究领域

My research interests are spread across three main areas with common threads running through each area. Historically my background has been in cardiovascular pharmacology and more specifically in myocardial ischaemia-reperfusion injury. I have studied the how the rennin-angiotensin system affects short- and long-term recovery from myocardial ischaemia-reperfusion injury. More recently, I am engaged in investigating cardiovascular responses to endocannabinoids and trace amines. I am also involved in pulmonary research where we are studying the effects of modifying components of the inflammatory response (including the use of endocannabinoids) to reduce inflammation and allergen-induced bronchoconstriction. Study of the endocannainoid system also forms the basis of a new collaboration with Norgine to study inflammatory bowel disease.

近期论文

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Evans, R.et al. 2015. Pulmonary oedema measured by MRI correlates with late-phase response to allergen challenge. Experimental Lung Research 41(4), pp. 189-198. (10.3109/01902148.2014.985407) pdf Lowe, A.et al. 2015. Lipopolysaccharide exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea-pig model of asthma. British Journal of Pharmacology 172(10), pp. 2588-2603. (10.1111/bph.13080) pdf Yarova, P.et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282) pdf Lowe, A.et al. 2015. Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs. Journal of Pharmacological and Toxicological Methods 72, pp. 85-93. (10.1016/j.vascn.2014.10.007) pdf Ford, W.et al. 2013. Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs. Clinical Science 125(10), pp. 471-482. (10.1042/CS20130130) Broadley, K.et al. 2013. Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines. European Journal of Pharmacology 715(1-3), pp. 370-380. (10.1016/j.ejphar.2013.04.034) Anwar, M.et al. 2013. Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed. Vascular Pharmacology 58(1-2), pp. 140-149., article number: 10.1016/j.vph.2012.10.007. (10.1016/j.vph.2012.10.007) pdf Evans, R.et al. 2012. A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma. Pulmonary Pharmacology & Therapeutics 25(6), pp. 453-464. (10.1016/j.pupt.2012.08.004) Turner, D.et al. 2012. Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. British Journal of Pharmacology 167(3), pp. 515-526. (10.1111/j.1476-5381.2012.02016.x)