Coulman, Sion - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

I graduated from the University of Wales, Cardiff in 2001 with an MPharm degree and subsequently moved into my pre-registration year in community pharmacy. In the summer of 2002 I became a member of the Royal Pharmaceutical Society Great Britain and began professional practice as a locum pharmacist, working part-time in the community sector. This coincided with the beginning of my PhD studies at Cardiff University where I spent three years investigating novel transdermal delivery systems for the delivery and expression of exogenous plasmid DNA in human skin. In 2005, whilst completing my PhD studies, I began a short contract at Cardiff University as a Teaching Fellow. In the summer of 2006 I took up a Lectureship at the School of Pharmacy and Pharmaceutical Sciences and I am now a Senior Lecturer.

研究领域

My principal research interest is the development of the microneedle device as a non-invasive method for trans/intra-dermal delivery of novel and existing medicines, and the translation of microneedle technology from a laboratory prototype to a clinically useful device. The microneedle device bridges engineering, pharmaceutics and healthcare disciplines and therefore I am part of multi-disciplinary teams that include academic and non-academic colleagues from the UK, Europe and the USA. The technology is now approaching clinical usefulness and over the forthcoming years will hopefully facilitate non-invasive delivery of a number of therapeutics and hence offer a range of new therapeutic opportunities. I also have an active research interest in the performance and use of capsule-based dry powder inhalers (DPIs), stimulated by a growing interest in the potential of DPIs as a means to deliver labile macromolecular drugs to the lung. Our research evaluates the performance of these devices, both in the laboratory and in the hands of the user. I also have a pedagogic interest in numeracy and medicines-based calculations, with a particular focus on the education of pharmacy students and pharmacists in this area. In collaboration with colleagues from Mathematics at Cardiff and Pharmacy in Brighton I have developed a contextualized diagnostic numeracy test that is currently being used at UK Schools of Pharmacy and Medicine.

近期论文

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Czubala, M.et al. 2016. TGFβ induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial langerhans cells. Journal of Investigative Dermatology 136(10), pp. 1981-1989. (10.1016/j.jid.2016.05.123) pdf Chong, R.et al. 2016. Evaluating the sensitivity, reproducibility and flexibility of a method to test hard shell capsules intended for use in dry powder inhalers. International Journal of Pharmaceutics 500(1-2), pp. 316-325. (10.1016/j.ijpharm.2016.01.034) pdf Zhao, X.et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040) pdf Shelvey, B., Coulman, S. and John, D. 2016. Evaluating an undergraduate interprofessional education (IPE) session for medical and pharmacy undergraduates on therapeutics and prescribing: the medical student perspective. Advances in Medical Education and Practice pdf Alhadjali, M.et al. 2015. Topical steroid therapy induces Pro-Tolerogenic changes in langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518) pdf Alrakaf, S.et al. 2015. An international comparison study of pharmacy students’ achievement goals and their relationship to assessment type and scores. American Journal of Pharmaceutical Education 79(3), pp. 1-8. (10.5688/ajpe79335) pdf Alrakaf, S.et al. 2014. An international validation study of two achievement goal measures in a pharmacy education context. Advances in Medical Education and Practice 2014(5), pp. 339-345. (10.2147/AMEP.S68241) pdf Griffiths, C.et al. 2014. Exploring MPharm students’; opinion on a specialist cancer treatment hospital placement. International Journal of Pharmacy Practice 22(S2), pp. 96-97. (10.1111/ijpp.12146) Chong, R.et al. 2013. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release 166(3), pp. 211-219. (10.1016/j.jconrel.2012.12.030) Groves, R.et al. 2013. An anisotropic, hyperelastic model for skin: experimental measurements, finite element modelling and identification of parameters for human and murine skin. Journal of the Mechanical Behaviour of Biomedical Materials 18, pp. 167-180. (10.1016/j.jmbbm.2012.10.021) Torrisi, B.et al. 2013. Pocketed microneedles for rapid delivery of a liquid-state botulinum toxin A formulation into human skin. Journal of Controlled Release 165(2), pp. 146-152. (10.1016/j.jconrel.2012.11.010)