Brancale, Andrea - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

I graduated in Medicinal Chemistry at the University of Rome "La Sapienza" in 1996, and moved to Cardiff in 1997. I completed my PhD at Cardiff University in 2001 under the supervision of Professor McGuigan working on a novel class on anti-VZV (Varicella Zoster Virus) nucleosides. Following a two year post-doctoral position under the supervision of Professor McGuigan, I was appointed lecturer in Medicinal Chemistry in 2002, Senior Lecturer in 2011 and promoted to Reader in 2015.

研究领域

Computer-aided design and develpment of novel antiviral and anticancer agents Molecular modeling software development My group research is focused on the use of computer-aided techniques to understand biological problems and develop novel potential drugs. Some representative projects are described below.

近期论文

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Hamdy, R.et al. 2017. Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents. Bioorganic & Medicinal Chemistry Letters 27(4), pp. 1037-1040. (10.1016/j.bmcl.2016.12.061) James, E.et al. 2017. Kinase-independent phosphoramidate S1P1 receptor agonist benzyl ether derivatives. Biorganic and Medicinal Chemistry Letters (10.1016/j.bmcl.2017.02.011) pdf Ziedan, N.et al. 2017. Virtual screening, SAR and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor. Chemical Biology and Drug Design (10.1111/cbdd.12936) pdf Bassetto, M.et al. 2017. In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase. European Journal of Medicinal Chemistry 125, pp. 1115-1131. (10.1016/j.ejmech.2016.10.043) pdf Bassetto, M.et al. 2017. Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV. Bioorganic & Medicinal Chemistry Letters (10.1016/j.bmcl.2016.12.087) pdf Kandil, S.et al. 2016. ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites. Biorganic and Medicinal Chemistry Letters 26(23), pp. 5618-5623. (10.1016/j.bmcl.2016.10.077) pdf Bassetto, M.et al. 2016. Structural biology in antiviral drug discovery. Current Opinion in Pharmacology 30, pp. 116-130. (10.1016/j.coph.2016.08.014) pdf Papale, A.et al. 2016. Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors. eLife 5, article number: e17111. (10.7554/eLife.17111) pdf Bassetto, M.et al. 2016. Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry 118, pp. 230-243. (10.1016/j.ejmech.2016.04.052) pdf Ferla, S.et al. 2016. Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic & Medicinal Chemistry Letters 26(15), pp. 3636-3640. (10.1016/j.bmcl.2016.06.001) pdf Bassetto, M.et al. 2016. Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication. European Journal of Medicinal Chemistry (10.1016/j.ejmech.2016.07.035) pdf