Birchall, James - Cardiff University - School of Pharmacy and Pharmaceutical Sciences

个人简介

August 2014 - Professor in Pharmaceutical Sciences. July 2013 - Chair in Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Cardiff University. Aug 2010 - June 2013 Reader in Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Cardiff University. Aug 2007 - July 2010 Senior Lecturer in Drug Delivery, School of Pharmacy and Pharmaceutical Sciences, Cardiff University. Feb 2001 - July 2007 Lecturer in Drug Delivery, School of Pharmacy and Pharmaceutical Sciences, Cardiff University. Mar 2006 - Present Honorary Senior Lecturer and Research Pharmacist, Gwent Healthcare NHS Trust. Jul 2005 - Aug 2005 Visiting Researcher, Georgia Institute of Technology, Atlanta, Georgia. Feb 2000 - Feb 2001 Teaching Fellow, Welsh School of Pharmacy, Cardiff University. Mar 1998 - Feb 2000 Research Associate, Drug Delivery Research Group, Welsh School of Pharmacy, Cardiff University. Aug 1994 - Present Locum Pharmacist, Various locations. Aug 1993 - Jul 1994 Pre-Registration Pharmacist, Abbott Laboratories Ltd., Kent; St. Georges Hospital, London.

研究领域

Enhanced delivery of therapeutic macromolecules to the skin via microfabricated microneedles The skin epidermis represents an appropriate target for the delivery of low molecular weight drugs, vaccines, biopharmaceuticals and gene based therapies. The skin, however, is characterised by poor permeability. Microfabricated microneedle arrays are designed to pierce the stratum corneum skin barrier layer in a minimally invasive and pain-free manner to provide transient pathways for the delivery of macromolecules to the underlying skin epidermis. Delivery of formations via pulmonary routes Although non-viral gene vectors are capable of mediating gene transfer both in vitro and in vivo following nebulisation, the delivery efficiency of conventional nebuliser systems is greatly reduced due to the restrictions of the device and the physico-chemical characteristics of the particles at elevated concentrations in the nebuliser reservoir. While newer nebuliser technologies are under development, pressurised metered-dose inhalers (pMDIs) and dry powder inhalers (DPIs) may provide more viable alternatives for delivering therapeutically active macromolecules, particularly genes, to the lung.

近期论文

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Nishio Ayre, W.et al. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(8), pp. 1510-1524. (10.1002/jbm.b.33488) pdf Czubala, M.et al. 2016. TGFβ induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial langerhans cells. Journal of Investigative Dermatology 136(10), pp. 1981-1989. (10.1016/j.jid.2016.05.123) pdf Caucheteux, S.et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136(6), pp. 1172-1181. (10.1016/j.jid.2016.01.033) pdf Teagle, A. R., Birchall, J. C. and Hargest, R. 2016. Gene therapy for pyoderma gangrenosum: optimal transfection conditions and effect of drugs on gene delivery in the HaCaT cell line using cationic liposomes. Skin Pharmacology and Physiology 29, pp. 119-129. (10.1159/000444859) pdf Chong, R.et al. 2016. Evaluating the sensitivity, reproducibility and flexibility of a method to test hard shell capsules intended for use in dry powder inhalers. International Journal of Pharmaceutics 500(1-2), pp. 316-325. (10.1016/j.ijpharm.2016.01.034) pdf Zhao, X.et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040) pdf Alhadjali, M.et al. 2015. Topical steroid therapy induces Pro-Tolerogenic changes in langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518) pdf Choi, H.et al. 2015. Design and in vitro interference test of microwave noninvasive blood glucose monitoring sensor. IEEE Transactions on Microwave Theory and Techniques 63(10), pp. 3016-3025. (10.1109/TMTT.2015.2472019) pdf Ivory, M. O., Birchall, J. C. and Piguet, V. 2015. Early dengue virus infection in human skin: a cycle of inflammation and infectivity [Commentary]. Journal of Investigative Dermatology 135(7), pp. 1711-1712. (10.1038/jid.2014.544) pdf Rattanapak, T.et al. 2014. Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization. PLOS ONE 9(2), article number: e89503. (10.1371/journal.pone.0089503) pdf Rattanapak, T.et al. 2013. Transcutaneous immunization using microneedles and cubosomes: Mechanistic investigations using Optical Coherence Tomography and Two-Photon Microscopy. Journal of Controlled Release 172(3), pp. 894-903. (10.1016/j.jconrel.2013.08.018) Pearton, M.et al. 2013. Host responses in human skin after conventional intradermal injection or microneedle administration of virus-like-particle influenza vaccine. Advanced Healthcare Materials 2(10), pp. 1401-1410. (10.1002/adhm.201300006)