Ye, Lin - Cardiff University - School of Medicine

个人简介

Education and qualifications 2004-2007: PhD, Cancer Biology, Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, UK 1993-1996: MSc, Master of Surgery, house officer at University Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China 1985-1993: MB and BCh, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China Career overview 2013-present: Lecturer of Cancer Biology and Oncology, Cardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK 2007-2013: Posdoctoral Research Associate, Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, UK 1996-2004: Lecturer of Surgery and Registrar, Department of Surgery, University Hospital of Shandong University of TCM, Jinan, Shandong, China

研究领域

My research interest is to investigate the cancer cells orientated cross-talks with the extracellular matrix (ECM) and stroma cells during the cancer development, progression and metastases. The first group of molecules of my interest is bone morphogenetic proteins and their signalling. BMPs play diverse and critical roles in a vicious cycle between cancer cells and the local environment in both primary and secondary tumours, and also contribute to the tumour-associated angiogenesis. Following my PhD study of bone morphogenetic proteins (BMP) and their signalling in prostate cancer, I continue to explore the mechanism(s) of bone metastasis from prostate cancer and breast cancer, seek and develop therapeutic approach particularly by targeting BMPs signalling. The second group of molecules which we focus are anthrax toxin receptor 1 (ANTXR1, also known as tumour endothelial marker 8, TEM-8) and anthrax toxin receptor 2 (ANTXR2, also known as capillary morphogenesis gene 2, CMG2). These two molecules are initially identified as markers or genes for the angiogenesis. Our recent studies have shown that aberrant expression and function of these two molecules in the disease progression of breast cancer and prostate cancer. As these two transmembrane proteins play an important role mediating adhesion and migration of cancer cells upon ECM, and also orchestrating the consequent interactions between cancer cells and micro-environment to enable tumour growth and dissemination.

近期论文

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Li, J.et al. 2017. Reduced NOV expression correlates with disease progression in colorectal cancer and is associated with survival, invasion and chemoresistance of cancer cells. Oncotarget (10.18632/oncotarget.15439) pdf Cai, S.et al. 2017. Expression of phospholipase C isozymes in human breast cancer and their clinical significance. Oncology Reports (10.3892/or.2017.5394) pdf Shi, L.et al. 2016. Clinical and therapeutic implications of follistatin in solid tumours. Cancer Genomics and Proteomics 13(6), pp. 425-435. (10.21873/cgp.200xx) pdf Ye, L. and Jiang, W. G. 2016. Bone morphogenetic proteins in tumour associated angiogenesis and implication in cancer therapies. Cancer Letters 380(2), pp. 586-597. (10.1016/j.canlet.2015.10.036) pdf Li, J.et al. 2016. Differential expression of CCN family members CYR611, CTGF and NOV in gastric cancer and their association with disease progression. Oncology Reports (10.3892/or.2016.5074) pdf Liu, R.et al. 2016. Epithelial protein lost in neoplasm-α (EPLIN-α) is a potential prognostic marker for the progression of epithelial ovarian cancer. International Journal of Oncology 48(6), pp. 2488-2496. (10.3892/ijo.2016.3462) Satherley, L.et al. 2016. Prostate Apoptosis Response-4 (PAR4) suppresses growth and invasion of breast cancer cells and is positively associated with patient survival. Anticancer Research 36(3), pp. 1227-1236. Shao, S.et al. 2016. Reduced RanBPM expression is associated with distant metastasis in gastric cancer and chemoresistance. Anticancer Research 36(3), pp. 1295-1304. Malik, M.et al. 2016. Expression of semaphorin 3C in breast cancer and its impact on adhesion and invasion of breast cancer cells. Anticancer Research 36(3), pp. 1281-1286. Li, J.et al. 2016. Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer. Oncotarget (10.18632/oncotarget.7463) Jia, J.et al. 2016. IL24 and its receptors regulate growth and migration of pancreatic cancer cells and are potential biomarkers for IL24 molecular therapy. Anticancer Research 36(3), pp. 1153-1163. Cai, S.et al. 2016. Expression of phospholipase C isozymes in human breast cancer and their clinical significance. Oncology Reports Wang, S.et al. 2015. Tumour endothelial marker-8 in wound healing and its impact on the proliferation and migration of keratinocytes. International Journal of Molecular Medicine , pp. 293-298. (10.3892/ijmm.2015.2434) pdf