个人简介

B.S., Boston College, 1995 Ph.D., Harvard University, 2000 Postdoctoral Associate, Harvard Medical School, 2000-2003

研究领域

Biochemistry

Biosynthesis of Natural Products, Organic Synthesis, Mechanistic Enzymology Structurally complex natural products, such as the medicinally relevant antibiotics vancomycin and erthromycin, are biosynthesized by large, macromolecular enzyme assemblies. These assemblies frequently orchestrate difficult and interesting chemical transformations t construct diverse molecular scaffolds. Our research group will use the tools of synthetic organic chemistry, enzymology and structural biology to dissect the mechanism of these systems. A detailed understanding of the biosynthesis of natural products will be extended to the development of new synthetic methodology and to the engineering of biological systems to produce novel molecules with desired properties.

近期论文

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Di Russo, NV, Bruner, SD, Roitberg, AE. Applicability of a fluorescence-based sensors to the determination of kinetic parameters for O2 in oxygenases. Anal. Biochem. 2015, in press. LINK Luo Z, Li Y, Mousa J, Bruner S, Zhang Y, Pei Y, Keyhani NO. Bbmsn2 acts as a pH-dependent negative regulator of secondary metabolite production in the entomopathogenic fungus Beauveria bassiana. Environ Microbiol. 2014, in press. LINK Condurso HL, Bruner SD. Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery. Nat Prod Rep. 2012, 29(10):1099-110. LINK Dimise EJ, Condurso HL, Stoker GE, Bruner SD. Synthesis and structure confirmation of fuscachelins A and B, structurally unique natural product siderophores from Thermobifida fusca. Org Biomol Chem. 2012, 10(28):5353-6. LINK Condurso HL, Bruner SD. Structure guided approaches toward exploiting and manipulating nonribosomal peptide and polyketide biosynthetic pathways. Curr Opin Chem Biol. 2012,16(1-2), 162-9. LINK Liu Y, Zheng T, Bruner SD. Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases. Chem Biol. 2011, 18(11), 1482-8. LINK Bruner SD. Enzyme catalysis: C-H activation is a Reiske business. Nat Chem. 2011 3(5), 342-3. LINK Cooke HA, Bruner SD. Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites. Biopolymers. 2010, 93(9), 802-10. LINK Dimise EJ, Bruner SD. Biosynthesis: unmasking morphine. Nat Chem Biol. 2010, 6(4), 251-2. LINK Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry. 2009, 48(40), 9590-8. LINK Cooke HA, Christianson CV, Bruner SD. Structure and chemistry of 4-methylideneimidazole-5-one containing enzymes. Curr Opin Chem Biol. 2009, 13(4), 460-8. LINK Widboom PF, Bruner SD. Complex oxidation chemistry in the biosynthetic pathways to vancomycin/teicoplanin antibiotics. Chembiochem. 2009, 10(11), 1757-64. LINK Dimise EJ, Widboom PF, Bruner SD. Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca. Proc Natl Acad Sci, 2008, 105(40), 15311-6. LINK Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B. Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. J Biol Chem. 2008, 283(21), 14694-702. LINK Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD. Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM. Bioorg Med Chem Lett. 2008,18(10), 3099-102. LINK Christianson CV, Montavon TJ, Festin GM, Cooke HA, Shen B, Bruner SD. The mechanism of MIO-based aminomutases in beta-amino acid biosynthesis. J Am Chem Soc. 2007, 129(51), 15744-5. LINK Fielding EN, Widboom PF, Bruner SD. Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC. Biochemistry. 2007, 46(49), 13994-4000. LINK Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD. Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. J Am Chem Soc. 2007, 129(25), 7728-9. LINK