Weeks, Ian - Cardiff University - School of Medicine

研究领域

Research and development of in vitro diagnostic methods based on ligand binding assays such as immunoassay, nucleic acid hybridisation assay and enzymological assay using high sensitivity end-points such as chemiluminescence. Particular emphasis on development of simple, non-invasive methods as alternatives to invasive clinical test procedures. Current research involves the application of the principles outlined above for the development of diagnostic tests for biomarkers of inflammation and cancer. The overarching strategic model for the research is to target areas where there is an unmet clinical need or where synergy of technologies can enhance clinical diagnosis and management of underlying pathologies. Such a strategy is beneficial to patients and cost-effective for the healthcare provider.

近期论文

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Morris, C.et al. 2017. Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicology in Vitro 39, pp. 15-28. (10.1016/j.tiv.2016.11.004) pdf Morris, C.et al. 2012. Utilising chemiluminescent methods for 'animal-free' toxicology tests [Abstract]. Toxicology Letters 211(Supp.), pp. S104-S105. (10.1016/j.toxlet.2012.03.390) Browne, K.et al. 2012. Spectrally resolved chemiluminescent probes for sensitive multiplex molecular quantification. Analytical Chemistry 84(21), pp. 9222-9229. (10.1021/ac3017423) Browne, K.et al. 2011. Simultaneous quantification of multiple nucleic acid targets using chemiluminescent probes. Journal of the American Chemical Society 133(37), pp. 14637-14648. (10.1021/ja202221h) Smith, K.et al. 2009. Synthesis and properties of novel chemiluminescent biological probes: 2- and 3-(2-Succinimidyloxycarbonylethyl)phenyl acridinium esters. Journal of Photochemistry and Photobiology A: Chemistry 203(1), pp. 72-79. (10.1016/j.jphotochem.2008.12.020) pdf Brown, R.et al. 2009. Development and application of a novel acridinium ester for use as a chemiluminescent emitter in nucleic acid hybridisation assays using chemiluminescence quenching. Organic and Biomolecular Chemistry 7(2), pp. 386-394. (10.1039/b811947c) Morris, C.et al. 2008. Comparison of transcription-mediated amplification and growth-based methods for the quantitation of Enterococcus bacteria in environmental waters. Applied and Environmental Microbiology 74(10), pp. 3319-3320. (10.1128/AEM.02623-07) Walkley, N.et al. 2008. Investigation of transcription-mediated amplification as a rapid test method for Enterococci in recreational water. Journal of Environmental Monitoring 10(9), pp. 1064-1068. (10.1039/b810284h)