Tonks, Alex - Cardiff University

个人简介

Education and significant professional training courses 2014: Fellow of the Higher Education Academy 2012-2014: ILM endorsed course for Practical Leadership for University Management, Cardiff University, Cardiff, UK 2012-2013: CPD in Medical Education Orientation Programme, School of Medicine, Cardiff University, Cardiff UK 1997-2000: PhD – Pulmonary immunology/ROS, Cardiff University / University of Wales Institute Cardiff (UWIC) 1996: HPC Registration for Biomedical Sciences, Health Professions Council, UK 1993-1997: BSc (Hons) Biomedical Sciences (Ist Class), UWIC, Cardiff, UK Career Overview **Present - Senior Lecturer, Department of Haematology, Cardiff University, UK 2003-2009 - Lecturer, Department of Haematology, Cardiff University, UK 2000-2003 - Post-doctoral Research Fellow, Department of Haematology, Cardiff University, UK 2000-2002 - Part time Lecturer, School of Applied Sciences, UWIC, Cardiff, UK 1997-2000 - Research Assistant, School of Applied Sciences, UWIC, Cardiff, UK

研究领域

Acute myeloid leukaemia (AML) still has a generally poor outcome particularly for those over sixty. Hope for the future comes in the form of treatments which target key abnormalities that are the “Achilles’ heel” of the disease; unfortunately AML is a highly variable disease and only one subtype of the disease is currently treated in this way. I investigate the roles of a number of candidate genes including RRUNX1-ETO, CD200, Wnt signalling, S100 and the production of reactive oxygen species (ROS) in leukamogenesis. In particular I am interested in how the process of haematopoietic development in stem and progenitor populations is dysregulated by these genes in AML.

近期论文

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Munje, C.et al. 2015. Cord blood-derived quiescent CD34+ cells are more transcriptionally matched to AML blasts than cytokine-induced normal human hematopoietic CD34+ cells. Gene Expression 16(4), pp. 169-175. (10.3727/105221615X14399878166159) pdf Coles, S.et al. 2015. The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse. Leukemia 29(9), pp. 1952. (10.1038/leu.2015.62) Morgan, R.et al. 2014. Factors affecting the nuclear localization of β-Catenin in normal and malignant tissue. Journal of Cellular Biochemistry 115(8), pp. 1351-1361. (10.1002/jcb.24803) Zabkiewicz, J.et al. 2014. The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts. Haematologica 99(5), pp. 858-864. (10.3324/haematol.2013.096487) Hole, P.et al. 2013. Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling. Blood 122(19), pp. 3322-3330. (10.1182/blood-2013-04-491944) Morgan, R.et al. 2013. γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin. Leukemia 27(2), pp. 336-343. (10.1038/leu.2012.221) pdf Daud, S.et al. 2012. Identification of the Wnt signalling protein, TCF7L2 as a significantly overexpressed transcription factor in AML [Abstract]. Blood 120(21), article number: 1281. Coles, S.et al. 2012. Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells [Letter]. Leukemia 26(9), pp. 2146-2148. (10.1038/leu.2012.75) pdf Coles, S.et al. 2012. Expression of CD200 on AML blasts directly suppresses memory T-cell function [Letter]. Leukemia 26(9), pp. 2148-2151. (10.1038/leu.2012.77) pdf Liddiard, K.et al. 2012. RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1 [Letter]. Leukemia 26(1), pp. 177-179. (10.1038/leu.2011.188) pdf